Graph-based analysis of mass spectrometry data for tissue characterization with application in basal cell carcinoma surgery

Akbarifar, Faranak; Jamzad, Amoon; Santilli, Alice; Kauffman, Martin; Janssen, Natasja; Connolly, Laura; Ren, Kevin; Vanderbeck, Kaitlin; Wang, Ami; McKay, Douglas R.; Rudan, John F.; Fichtinger, Gabor; Mousavi, Parvin

doi:10.1117/12.2582045

Cited by 3 publications

(1 citation statement)

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“…Furthermore, the resulting specimens from the LCM could also be transferred to a mass analyzer [ 89 ], thus obtaining mass spectra profiles for the selected cancer samples. A step forward was made in this direction and the separation of normal vs. BCC tissue was done with high accuracy with an aim toward real-time margin assessment during BCC surgery [ 90 ].…”

Section: Discussionmentioning

confidence: 99%

Nodular and Micronodular Basal Cell Carcinoma Subtypes Are Different Tumors Based on Their Morphological Architecture and Their Interaction with the Surrounding Stroma

et al. 2022

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Basal cell carcinoma (BCC) is the most frequent cancer of the skin and comprises low-risk and high-risk subtypes. We selected a low-risk subtype, namely, nodular (N), and a high-risk subtype, namely, micronodular (MN), with the aim to identify differences between them using a classical morphometric approach through a gray-level co-occurrence matrix and histogram analysis, as well as an approach based on deep learning semantic segmentation. From whole-slide images, pathologists selected 216 N and 201 MN BCC images. The two groups were then manually segmented and compared based on four morphological areas: center of the BCC islands (tumor, T), peripheral palisading of the BCC islands (touching tumor, TT), peritumoral cleft (PC) and surrounding stroma (S). We found that the TT pattern varied the least, while the PC pattern varied the most between the two subtypes. The combination of two distinct analysis approaches yielded fresh insights into the characterization of BCC, and thus, we were able to describe two different morphological patterns for the T component of the two subtypes.

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Section: Discussionmentioning

confidence: 99%