Given graphs H and F, a subgraph G⊆H is an F‐saturated subgraph of H if F⊈G, but F⊆G+e for all e∈E(H)∖E(G). The saturation number of F in H, denoted sat (H,F), is the minimum number of edges in an F‐saturated subgraph of H. In this article, we study saturation numbers of tripartite graphs in tripartite graphs. For ℓ≥1 and n1, n2, and n3 sufficiently large, we determine sat (Kn1,n2,n3,Kℓ,ℓ,ℓ) and sat (Kn1,n2,n3,Kℓ,ℓ,ℓ−1) exactly and sat (Kn1,n2,n3,Kℓ,ℓ,ℓ−2) within an additive constant. We also include general constructions of Kℓ,m,p‐saturated subgraphs of Kn1,n2,n3 with few edges for ℓ≥m≥p>0.