This paper studies topology inference, from agent states, of a directed cyber-social network with opinion spreading dynamics model that explicitly takes confirmation bias into account. The cyber-social network comprises a set of partially connected directed network of agents at the social level, and a set of information sources at the cyber layer. The necessary and sufficient conditions for the existence of exact inference solution are characterized. A method for exact inference, when it is possible, of entire network topology as well as confirmation bias model parameters is proposed for the case where the bias mentioned earlier follows a piece-wise linear model. The particular case of no confirmation bias is analyzed in detail. For the setting where this model is not piece-wise linear, an algorithm that approximates the network topology, building on the exact inference method, is presented. Numerical simulations demonstrate the effectiveness of the proposed methods and algorithm for different scenarios.