Graphene and graphene-based nanocomposites: biomedical applications and biosafety

Pattnaik, Satyanarayan; Swain, Kalpana; Lin, Zhiqun

doi:10.1039/c6tb02086k

Cited by 158 publications

(106 citation statements)

References 136 publications

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“…Both materials contain functional groups on their surfaces which improve their hydrophilic properties, and they can be further functionalized to tailor their properties for intended purposes. On the other hand, the lipophilicity of GR can be used in membrane barrier penetration systems [9].…”

Section: Introductionmentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Introductionmentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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“…Moreover, graphene is used as nanoscale building blocks for new nanocomposites because of its unique properties [12][13][14]. Recent research showed that magnetic nanoparticles (MNPs) could be attached to graphene, which can be applied in magnetic resonance imaging [15], targeted drug delivery [16,17], biocompatible adsorbent [18], magnetic solid phase extraction [19], microwave electromagnetic [20], Schottky diode applications [21], and biomolecule immobilization [22].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Zhang

Wen-bin

et al. 2017

Journal of Nanomaterials

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The Fe 3 O 4 /reduced graphene oxide (Fe 3 O 4 /RGO) nanocomposites with good dispersibility were synthesized for targeted delivery of paclitaxel (PTX). Firstly, the superparamagnetic Fe 3 O 4 /functional GO nanocomposites were prepared via hydrothermal method in which GO sheets were modified by surfactant wrapping. The Fe 3 O 4 /RGO nanocomposites were successively prepared through the reduction of graphene oxide. The products were investigated by Fourier-transform infrared spectrum, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and vibration sample magnetometry. It was found that spherical Fe 3 O 4 nanoparticles were uniformly anchored over the RGO matrix and the nanocomposites were superparamagnetic with saturation magnetization (Ms) of 9.39 emu/g. Then PTX was loaded onto Fe 3 O 4 /RGO nanocomposites, and the drug loading capacity was 67.9%. Cell viability experiments performed on MCF-7 demonstrated that the Fe 3 O 4 /RGOloaded PTX (Fe 3 O 4 /RGO/PTX) showed cytotoxicity to MCF-7, whereas the Fe 3 O 4 /RGO displayed no obvious cytotoxicity. The above results indicated that Fe 3 O 4 /RGO/PTX nanocomposites had potential application in tumor-targeted chemotherapy.

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“…This very specific property along with the other interesting physiochemical features of carbon nanomaterials (CNMs) have ushered in a new biomedical era. In addition to their early medical applications in biosensors and bioimaging contrast agents, recently, a series of studies have been published on CNMs‐based advancements in regenerative medicine, tissue engineering, drug delivery, and nonviral gene transfer (Alshehri et al, ; Georgakilas et al, ; G. Hong, Diao, Antaris, & Dai, ; J. Lee, Kim, Kim, & Min, ; Pattnaik, Swain, & Lin, ; Zheng, Ananthanarayanan, Luo, & Chen, ). Despite these beneficial contributions, the potential applications of CNMs have not been expanded to the clinical trial stage as yet.…”

Section: Introductionmentioning

confidence: 99%

Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials

Mohajeri

Behnam

Sahebkar

2018

Journal Cellular Physiology

215

100

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One of the major components in the development of nanomedicines is the choice of the right biomaterial, which notably determines the subsequent biological responses. The popularity of carbon nanomaterials (CNMs) has been on the rise due to their numerous applications in the fields of drug delivery, bioimaging, tissue engineering, and biosensing. Owing to their considerably high surface area, multifunctional surface chemistry, and excellent optical activity, novel functionalized CNMs possess efficient drug-loading capacity, biocompatibility, and lack of immunogenicity. Over the past few decades, several advances have been made on the functionalization of CNMs to minimize their health concerns and enhance their biosafety. Recent evidence has also implied that CNMs can be functionalized with bioactive peptides, proteins, nucleic acids, and drugs to achieve composites with remarkably low toxicity and high pharmaceutical efficiency. This review focuses on the three main classes of CNMs, including fullerenes, graphenes, and carbon nanotubes, and their recent biomedical applications.

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Graphene and graphene-based nanocomposites: biomedical applications and biosafety

Abstract: Graphene is the first carbon-based two dimensional atomic crystal and has gained much attention since its discovery by Geim and co-workers in 2004.

Cited by 158 publications

References 136 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials

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Graphene and graphene-based nanocomposites: biomedical applications and biosafety

Abstract: Graphene is the first carbon-based two dimensional atomic crystal and has gained much attention since its discovery by Geim and co-workers in 2004.

Cited by 158 publications

References 136 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Preparation of Fe3O4/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials

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Preparation of Fe₃O₄/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel