Graphene and Graphene Oxide for Tissue Engineering and Regeneration

Shang, Luoran; Qi, Yaping; Lü, He‐Zuo; Pei, Hao; Li, Yiwei; Qu, Liangliang; Wu, Zhengwei; Zhang, Weixia

doi:10.1016/b978-0-12-815341-3.00007-9

Cited by 37 publications

(29 citation statements)

References 103 publications

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“…In this case, it can be seen that the presence of CS or GO in the cement formulation enhances the capacity of HOb for surface colonization and proliferation at early stages when compared with control ABC. This observation is in agreement with other authors that have reported the benefits of GO [49] and CS [50] for cell attachment and proliferation and indicates that all the studied formulations have a high potential to be used as a biomaterial in bone treatment applications.…”

Section: Resultssupporting

confidence: 93%

“…Likewise, other researchers indicated that both GO and CS have a high potential in orthopedic tissue engineering [19] thanks to the fact that they have shown an increase in the proliferation of chondrocytes [21]. They induce attachment and proliferation of mouse mesenchymal stem cells (MSCs) and stimulate expression of the osteogenic gene osteocalcin, thus leading to differentiation of MSCs into bone [50]. They are cytofriendly to rat osteoprogenitor cells, enhance differentiation of MSCs into osteoblasts, and also accelerate bridging of the rat tibial bone defect with increased collagen deposition [52].…”

Section: Resultsmentioning

confidence: 99%

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Novel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan

Zapata

Mina

Grande-Tovar

et al. 2019

IJMS

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Acrylic bone cements (ABCs) have played a key role in orthopedic surgery mainly in arthroplasties, but their use is increasingly extending to other applications, such as remodeling of cancerous bones, cranioplasties, and vertebroplasties. However, these materials present some limitations related to their inert behavior and the risk of infection after implantation, which leads to a lack of attachment and makes necessary new surgical interventions. In this research, the physicochemical, thermal, mechanical, and biological properties of ABCs modified with chitosan (CS) and graphene oxide (GO) were studied. Fourier transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) scanning electron microscopy (SEM), Raman mapping, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), compression resistance, mechanical dynamic analysis (DMA), hydrolytic degradation, cell viability, alkaline phosphatase (ALP) activity with human osteoblasts (HOb), and antibacterial activity against Gram-negative bacteria Escherichia coli were used to characterize the ABCs. The results revealed good dispersion of GO nanosheets in the ABCs. GO provided an increase in antibacterial activity, roughness, and flexural behavior, while CS generated porosity, increased the rate of degradation, and decreased compression properties. All ABCs were not cytotoxic and support good cell viability of HOb. The novel formulation of ABCs containing GO and CS simultaneously, increased the thermal stability, flexural modulus, antibacterial behavior, and osteogenic activity, which gives it a high potential for its uses in orthopedic applications.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Novel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan

Zapata

Mina

Grande-Tovar

et al. 2019

IJMS

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“…Application of graphene nanomaterials has been largely exploited in several fields, from electronics to sensing and photonics, but only to a minor extent in nanomedicine. 7 Graphene and graphene oxide have been used as anti-bacterial agents, and for drug or gene delivery, 8 cancer therapy, 9 engineering stem cells, 10 tissue engineering, 11 biosensing 12 and bioimaging. 13 …”

Section: Interaction Of Viruses and Graphenementioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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“…As expected, BC/GO scaffolds displayed a better cellular adhesion, spreading, proliferation and osteogenic differentiation compared to neat BC and BC/GE. A possible explanation could be that GO’s hydrophilic surface groups provide an improved cytocompatibility [ 87 , 88 ].…”

Section: Cellulose Composites With Graphene For Tissue Engineeringmentioning

confidence: 99%

Cellulose Composites with Graphene for Tissue Engineering Applications

Oprea

Voicu

2020

Materials

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Tissue engineering is an interdisciplinary field that combines principles of engineering and life sciences to obtain biomaterials capable of maintaining, improving, or substituting the function of various tissues or even an entire organ. In virtue of its high availability, biocompatibility and versatility, cellulose was considered a promising platform for such applications. The combination of cellulose with graphene or graphene derivatives leads to the obtainment of superior composites in terms of cellular attachment, growth and proliferation, integration into host tissue, and stem cell differentiation toward specific lineages. The current review provides an up-to-date summary of the status of the field of cellulose composites with graphene for tissue engineering applications. The preparation methods and the biological performance of cellulose paper, bacterial cellulose, and cellulose derivatives-based composites with graphene, graphene oxide and reduced graphene oxide were mainly discussed. The importance of the cellulose-based matrix and the contribution of graphene and graphene derivatives fillers as well as several key applications of these hybrid materials, particularly for the development of multifunctional scaffolds for cell culture, bone and neural tissue regeneration were also highlighted.

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Graphene and Graphene Oxide for Tissue Engineering and Regeneration

Cited by 37 publications

References 103 publications

Novel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan

Novel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Cellulose Composites with Graphene for Tissue Engineering Applications

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