Graphene-based cardiac sensors and actuators

Savchenko, A. K.; Kireev, Dmitry; Yin, Rose T.; Efimov, Igor R.; Molokanova, Elena

doi:10.3389/fbioe.2023.1168667

Cited by 6 publications

(1 citation statement)

References 109 publications

(174 reference statements)

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“…Typical biomedical applications for GO and rGO include: 1) drug and therapeutic gene and cellular delivery, that take advantage of graphene chemical stability, the large surface area to increase the load rate and the easily functionalised surface chemistry; 2) phototherapy, that exploits GO photothermal effect to kill undesired cells and tumors; 3) biosensing, for which rGO is usually preferred with respect to GO for its higher conductivity; 4) bioimaging, that uses graphene as contrast agents in fluorescence, photoacoustic and magnetic resonance imaging; 5) sensing for RNA/DNA, glucose or disease biomarkers; and 6) antibacterial activity via oxidation and membrane stress (Bramini et al, 2018;Geetha Bai et al, 2018;Yan et al, 2019;Karki et al, 2020;Li et al, 2021;Cellot et al, 2022). Furthermore, GBMs such as LPE graphene, GO and rGO have been used in form of composites, foams, fibers and hydrogels to design tissue engineering 3D scaffolds with enhanced electrical and mechanical properties, to better mimic the in vivo environment (Bramini et al, 2018;Vlăsceanu et al, 2019;Savchenko et al, 2021;Lyu et al, 2022). Bottom-up synthesis of graphene, on the other end, allows one to obtain highly crystalline graphene on large (i.e., up to wafer) scale.…”

Section: Graphene and Gbms: Production Methods And Main Biomedical Ap...mentioning

confidence: 99%

Graphene-based nanomaterials for peripheral nerve regeneration

Convertino,

Trincavelli,

Giacomelli

et al. 2023

Front. Bioeng. Biotechnol.

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Emerging nanotechnologies offer numerous opportunities in the field of regenerative medicine and have been widely explored to design novel scaffolds for the regeneration and stimulation of nerve tissue. In this review, we focus on peripheral nerve regeneration. First, we introduce the biomedical problem and the present status of nerve conduits that can be used to guide, fasten and enhance regeneration. Then, we thoroughly discuss graphene as an emerging candidate in nerve tissue engineering, in light of its chemical, tribological and electrical properties. We introduce the graphene forms commonly used as neural interfaces, briefly review their applications, and discuss their potential toxicity. We then focus on the adoption of graphene in peripheral nervous system applications, a research field that has gained in the last years ever-increasing attention. We discuss the potential integration of graphene in guidance conduits, and critically review graphene interaction not only with peripheral neurons, but also with non-neural cells involved in nerve regeneration; indeed, the latter have recently emerged as central players in modulating the immune and inflammatory response and accelerating the growth of new tissue.

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Section: Graphene and Gbms: Production Methods And Main Biomedical Ap...mentioning

confidence: 99%

Graphene-based nanomaterials for peripheral nerve regeneration

Convertino,

Trincavelli,

Giacomelli

et al. 2023

Front. Bioeng. Biotechnol.

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Application of biomaterials in cardiac tissue engineering: Current status and prospects

Zhang,

He,

et al. 2024

MedComm – Biomaterials and Applications

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Cardiovascular diseases have become one of the leading causes of death and illness worldwide, posing significant challenges to global health. Due to the limited regenerative capacity of the heart, conventional approaches to treating heart diseases have demonstrated limited effectiveness. Therefore, leveraging biomaterials and biotechnologies in cardiac tissue engineering has emerged as a promising therapeutic strategy. This review aims to summarize the various characteristics of biomaterials in cardiac tissue engineering and their significance in addressing heart diseases. We categorize biomaterials into natural, synthetic, and conductive types based on their sources and unique properties, focusing on their applications in cardiac tissue engineering. We then present current applications of biomaterials in cardiac tissue engineering, followed by a discussion of existing challenges such as long‐term material stability, biocompatibility, adverse reactions, and precise application methodologies. Additionally, we provide insights into potential strategies for overcoming these challenges, aiming to enhance the effectiveness and safety of biomaterials in cardiac tissue engineering applications. Finally, this review highlights the potential of emerging biomaterials and technologies, underscoring the critical role of interdisciplinary collaboration in driving innovation and progress in cardiac tissue engineering.

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