Graphene-based field effect transistor enzymatic glucose biosensor using silk protein for enzyme immobilization and device substrate

You, Xueqiu; Pak, James Jungho

doi:10.1016/j.snb.2014.04.079

Cited by 141 publications

(87 citation statements)

References 43 publications

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“…[ 91,92 ] In the graphene FET sensors, GOD is also used and reacts with glucose to form H 2 O 2 . H 2 O 2 subsequently reacts with the graphene channel of the FET, effectively doping it and changing its conductance.…”

Section: Reviewmentioning

confidence: 99%

“…[ 91 ] The chemical structure of silk fi broin results in nanoscale pockets that immobilize GOD on the sensor. A CVDgrown graphene channel was transferred to a silk substrate and Au/Ti source/drain electrodes were deposited on its opposite ends, forming the FET structure.…”

Section: Reviewmentioning

confidence: 99%

“…These functional inks may be deposited on a variety of substrates, ranging from plastic to textiles, using scalable roll-to-roll Reproduced with permission. [ 91 ] Copyright 2014, Elsevier. REVIEW compatible printing methods.…”

Section: Reviewmentioning

confidence: 99%

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Monitoring of Vital Signs with Flexible and Wearable Medical Devices

et al. 2016

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Advances in wireless technologies, low-power electronics, the internet of things, and in the domain of connected health are driving innovations in wearable medical devices at a tremendous pace. Wearable sensor systems composed of flexible and stretchable materials have the potential to better interface to the human skin, whereas silicon-based electronics are extremely efficient in sensor data processing and transmission. Therefore, flexible and stretchable sensors combined with low-power silicon-based electronics are a viable and efficient approach for medical monitoring. Flexible medical devices designed for monitoring human vital signs, such as body temperature, heart rate, respiration rate, blood pressure, pulse oxygenation, and blood glucose have applications in both fitness monitoring and medical diagnostics. As a review of the latest development in flexible and wearable human vitals sensors, the essential components required for vitals sensors are outlined and discussed here, including the reported sensor systems, sensing mechanisms, sensor fabrication, power, and data processing requirements.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Monitoring of Vital Signs with Flexible and Wearable Medical Devices

et al. 2016

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“…II), which are sensitive enough for non-invasive glucose detections in body fluids. It is noteworthy that GFET glucose biosensors has also been fabricated on flexible supports such as PET (Polyethylene terephthalate) [197] and silk fibroin [198] . As a continuous effort to achieve flexible and cheap biosensors, recently a GFET was implemented within an 2D paper network for practical glucose detection (~1.25 mM).…”

Section: Gfet Glucose Dna and Protein Biosensorsmentioning

confidence: 99%

Sensing at the Surface of Graphene Field‐Effect Transistors

et al. 2016

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Abstract. 10Recent research trends now offer new opportunities for developing the next generations of label-free biochemical sensors using graphene and other two-dimensional materials. While the physics of graphene transistors operated in electrolyte is well grounded, important chemical challenges still remain to be addressed, namely the impact of the chemical functionalizations of graphene on the key electrical parameters and the sensing performances. In fact, graphene -at least ideal graphene -is highly chemically inert. The 15 functionalizations and chemical alterations of the graphene surface -both covalently and non-covalently -are crucial steps that define the sensitivity of graphene. The presence, reactivity, adsorption of gas and ions, proteins, DNA, cells and tissues on graphene have been successfully monitored with graphene. This review aims to unify most of the work done so far on biochemical sensing at the surface of a (chemically functionalized) graphene field-effect transistor and the challenges that lie ahead. We are convinced that graphene biochemical sensors 20 hold great promises to meet the ever-increasing demand for sensitivity, especially looking at the recent progresses suggesting that the obstacle of Debye screening can be overcome.2

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“…[ 171 ] A silk-fi broin gate-dielectric fi lm was embedded with glucose oxidase enzyme and acted as the glucose-sensitive layer, which induced the graphene conductance change under catalytic response of glucose. The fl exible graphene FET biosensor showed a stable enzyme activity and a linear response to glucose in the range of 0.1-10 × 10 −3 M , which is promising for implantable continuous-glucose-monitoring applications.…”

Section: Reviewmentioning

confidence: 99%

Silk Fibroin for Flexible Electronic Devices

et al. 2015

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Flexible electronic devices are necessary for applications involving unconventional interfaces, such as soft and curved biological systems, in which traditional silicon-based electronics would confront a mechanical mismatch. Biological polymers offer new opportunities for flexible electronic devices by virtue of their biocompatibility, environmental benignity, and sustainability, as well as low cost. As an intriguing and abundant biomaterial, silk offers exquisite mechanical, optical, and electrical properties that are advantageous toward the development of next-generation biocompatible electronic devices. The utilization of silk fibroin is emphasized as both passive and active components in flexible electronic devices. The employment of biocompatible and biosustainable silk materials revolutionizes state-of-the-art electronic devices and systems that currently rely on conventional semiconductor technologies. Advances in silk-based electronic devices would open new avenues for employing biomaterials in the design and integration of high-performance biointegrated electronics for future applications in consumer electronics, computing technologies, and biomedical diagnosis, as well as human-machine interfaces.

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Graphene-based field effect transistor enzymatic glucose biosensor using silk protein for enzyme immobilization and device substrate

Cited by 141 publications

References 43 publications

Monitoring of Vital Signs with Flexible and Wearable Medical Devices

Monitoring of Vital Signs with Flexible and Wearable Medical Devices

Sensing at the Surface of Graphene Field‐Effect Transistors

Silk Fibroin for Flexible Electronic Devices

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