Graphene-Based Nanomaterials Toxicity in Fish

Dasmahapatra, Asok K.; Dasari, Thabitha P.; Tchounwou, Paul B.

doi:10.1007/398_2018_15

Cited by 34 publications

(47 citation statements)

References 90 publications

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“…The aggregation and stability of graphene nanomaterial can alter its physiochemical dimensions such as size and effective surface area, which may modulate toxicity to aquatic animals including fish [88]. The zebrafish embryos are covered by transparent acellular membrane called chorion, which acts as primary barrier that prevents the entry of exogenous materials including graphene nanomaterials from external environment in embryo's body [65,94]. The route of graphene exposure, accumulation, and bio-distribution has been investigated previously.…”

Section: Exposure Accumulation and Bio-distribution Of Graphene In mentioning

confidence: 99%

“…Hence, it becomes important to analyze the toxicity criteria of graphene-related nanomaterials to help understand the specific mechanism of their working with various modifications, dose, physiochemical properties, and model organisms. The information regarding overall concentration of graphene and GO being released in aquatic environment is unknown [65]. However, the concentration of engineered nanomaterials based on probabilistic material free computer model ranges from ng/L to µg/L [113].…”

Section: Current Understanding Of Graphene and Graphene Oxide (Go) Tomentioning

confidence: 99%

“…On the other hand, fish is an important species in the aquatic food chain. Fish is potentially exposed to released nanoparticles to the environment via the food chain or by direct absorption/adsorption from aquatic medium [65]. The fish model includes sensitive early life-stage bioassays, sensitivity to dissolved chemicals and materials, low rearing cost, and homology with the human genome.…”

Section: Introductionmentioning

confidence: 99%

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Toxicity Studies on Graphene-Based Nanomaterials in Aquatic Organisms: Current Understanding

et al. 2020

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Graphene and its oxide are nanomaterials considered currently to be very promising because of their great potential applications in various industries. The exceptional physiochemical properties of graphene, particularly thermal conductivity, electron mobility, high surface area, and mechanical strength, promise development of novel or enhanced technologies in industries. The diverse applications of graphene and graphene oxide (GO) include energy storage, sensors, generators, light processing, electronics, and targeted drug delivery. However, the extensive use and exposure to graphene and GO might pose a great threat to living organisms and ultimately to human health. The toxicity data of graphene and GO is still insufficient to point out its side effects to different living organisms. Their accumulation in the aquatic environment might create complex problems in aquatic food chains and aquatic habitats leading to debilitating health effects in humans. The potential toxic effects of graphene and GO are not fully understood. However, they have been reported to cause agglomeration, long-term persistence, and toxic effects penetrating cell membrane and interacting with cellular components. In this review paper, we have primarily focused on the toxic effects of graphene and GO caused on aquatic invertebrates and fish (cell line and organisms). Here, we aim to point out the current understanding and knowledge gaps of graphene and GO toxicity.

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Section: Exposure Accumulation and Bio-distribution Of Graphene In mentioning

confidence: 99%

Section: Current Understanding Of Graphene and Graphene Oxide (Go) Tomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicity Studies on Graphene-Based Nanomaterials in Aquatic Organisms: Current Understanding

et al. 2020

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“…Among the required characteristics of biomedical nano-platforms, good biocompatibility is a key characteristic. In this framework, different reports have explored the potential harmful bio-effects of several graphene nanostructures on in vitro and in vivo models, revealing the interactions of different graphene-based nanomaterials at cellular and tissues interfaces [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. The exposure of GRM to different cellular models induced toxicity in most cases, due to the interactions of GRM with several biomolecules, such as DNA, proteins and components of the cellular membrane [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…To understand the possible chronic effects of GRM, different in vivo toxicological screenings were carried out in zebrafish ( Danio rerio ) and mouse models. The interactions between different graphene-related nanomaterials and zebrafish caused several perturbations in the toxicological endpoints, in particular an increase in the mortality rate and delay in the chorion aperture (hatching rate) [ 17 , 19 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Among the graphene family, mainly graphene oxide (GO) and nanographene oxide (NGO) were investigated in terms of toxicity in zebrafish.…”

Section: Introductionmentioning

confidence: 99%

Graphene-Like Layers from Carbon Black: In Vivo Toxicity Assessment

et al. 2020

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Graphene-like (GL) layers, a new graphene-related material (GRM), possess peculiar chemical, colloidal, optical and transport properties. Considering the very recent promising application of GL layers in biomedical and bioelectronic fields, it is of utmost importance to investigate the toxicological profile of these nanomaterials. This study represents an important first report of a complete in vivo toxicity assessment of GL layers on embryonic zebrafish (Danio rerio). Our results show that GL layers do not lead to any perturbations in the different biological parameters evaluated, indicating their good biocompatibility on a vertebrate model. The new insight into the biosafety of GL layers will expand their applications in nanomedicine.

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Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

et al. 2021

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drug delivery, bioimaging probes, antibacterial agents, and tissue engineering. [2] The advantage of GBMs over other nanomaterials (NMs) in biomedical application is their high specific surface area which allows high density functionalization and drug loading on both sides of the planar structure. [3] The π-conjugated system offers high capacity for GBMs to interact with various organic compounds with aromatic structures through π-π stacking during fabrication of graphene composites or for immobilization of biomolecules such as nucleic acids, peptides, antibodies, or other therapeutic substances. [4] The same properties may also raise concerns regarding the potential risk that GBMs may cause to human health through binding of key signaling molecules for example. GBMs may interact with biomolecules, changing the structure of protein or DNA or induce oxidative damage, and so on. [5] Therefore, prior to the widespread use of GBMs, it is imperative to evaluate their potential risk to environmental and human health and to establish a proactive approach for the safe design of these materials.In a recent review article, Fadeel et al. comprehensively examined the literature on the effects of GBMs on human health and the environment and gave an overview of the state-of-the-art of safety assessment of GBMs, highlighting the importance of The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.

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Graphene-Based Nanomaterials Toxicity in Fish

Cited by 34 publications

References 90 publications

Toxicity Studies on Graphene-Based Nanomaterials in Aquatic Organisms: Current Understanding

Toxicity Studies on Graphene-Based Nanomaterials in Aquatic Organisms: Current Understanding

Graphene-Like Layers from Carbon Black: In Vivo Toxicity Assessment

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

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