Graphene Coating Obtained in a Cold-Wall CVD Process on the Co-Cr Alloy (L-605) for Medical Applications

Wasyluk, Łukasz; Boiko, Vitalii; Markowska, Marta; Hasiak, M.; Saladino, Maria Luisa; Hreniak, D.; Amati, Matteo; Gregoratti, Luca; Zeller, Patrick; Biały, Dariusz; Arkowski, Jacek; Wawrzyńska, Magdalena

doi:10.3390/ijms22062917

Cited by 7 publications

(3 citation statements)

References 33 publications

(29 reference statements)

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“…Several studies have assessed GBM-induced DNA damage in bacteria. The mutagenic capacity of different types of GO [ 89 ], graphene quantum dots (GQDs) [ 90 ], and exfoliated graphene [ 91 ], as well as graphene-coated cobalt–chromium discs [ 92 ], have been assessed using the validated bacterial gene mutation assay or Ames test (OECD TG 471) [ 93 ]. All the tested materials reported negative results, except GQDs displaying a clear dose-dependent response in the Salmonella typhimurium strains TA102 and TA104.…”

Section: Resultsmentioning

confidence: 99%

Genotoxicity of Graphene-Based Materials

et al. 2022

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Graphene-based materials (GBMs) are a broad family of novel carbon-based nanomaterials with many nanotechnology applications. The increasing market of GBMs raises concerns on their possible impact on human health. Here, we review the existing literature on the genotoxic potential of GBMs over the last ten years. A total of 50 articles including in vitro, in vivo, in silico, and human biomonitoring studies were selected. Graphene oxides were the most analyzed materials, followed by reduced graphene oxides. Most of the evaluations were performed in vitro using the comet assay (detecting DNA damage). The micronucleus assay (detecting chromosome damage) was the most used validated assay, whereas only two publications reported results on mammalian gene mutations. The same material was rarely assessed with more than one assay. Despite inhalation being the main exposure route in occupational settings, only one in vivo study used intratracheal instillation, and another one reported human biomonitoring data. Based on the studies, some GBMs have the potential to induce genetic damage, although the type of damage depends on the material. The broad variability of GBMs, cellular systems and methods used in the studies precludes the identification of physico-chemical properties that could drive the genotoxicity response to GBMs.

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Section: Resultsmentioning

confidence: 99%

Genotoxicity of Graphene-Based Materials

et al. 2022

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“…[ 226 ] Graphene, a 2D structure formed of a single layer of carbon atoms, exhibits exceptional conductivity and surface area, and its inert nature allows it to coat electrodes or other materials. [ 227 ] Noteworthy graphene derivatives include graphene oxide (GO) and reduced GO. By altering graphene's fineness and layered structure, they achieve very high flux and bestow new properties onto graphene.…”

Section: Electromagnetic Neural Stimulation Materialsmentioning

confidence: 99%

Advances in Material‐Assisted Electromagnetic Neural Stimulation

Sun,

Xiao,

Chen

et al. 2024

Advanced Materials

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Bioelectricity plays a crucial role in organisms, being closely connected to neural activity and physiological processes. Disruptions in the nervous system can lead to chaotic ionic currents at the injured site, causing disturbances in the local cellular microenvironment, impairing biological pathways, and resulting in a loss of neural functions. Electromagnetic stimulation has the ability to generate internal currents, which can be utilized to counter tissue damage and aid in the restoration of movement in paralyzed limbs. By incorporating implanted materials, electromagnetic stimulation can be targeted more accurately, thereby significantly improving the effectiveness and safety of such interventions. Currently, there have been significant advancements in the development of numerous promising electromagnetic stimulation strategies with diverse materials. This review provides a comprehensive summary of the fundamental theories, neural stimulation modulating materials, material application strategies, and pre‐clinical therapeutic effects associated with electromagnetic stimulation for neural repair. It offers a thorough analysis of current techniques that employ materials to enhance electromagnetic stimulation, as well as potential therapeutic strategies for future applications.This article is protected by copyright. All rights reserved

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“…For effective coating, it is necessary to prepare the surface of the substrate to be coated and to optimize the chemical vapor deposition process, allowing better attachment, e.g., by using the defective interface side of the graphene layer for bonding. In this regard, Wasyluk et al [ 9 ] synthesized a graphene coating on a Co-Cr alloy by a cold wall chemical vapor deposition (CW-CVD) method, with good mechanical properties (namely, hardness and elastic modulus). The results of the hemocompatibility test indicate that the developed coating does not have a pro-coagulant effect, thus corroborating its potential for medical applications, particularly in the field of cardiovascular diseases.…”

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confidence: 99%