Graphene–DNA hybrid materials: Assembly, applications, and prospects

Premkumar, Thathan; Geckeler, Kurt E.

doi:10.1016/j.progpolymsci.2011.08.003

Cited by 143 publications

(73 citation statements)

References 120 publications

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“…Graphene oxide (GO) is a novel carbon nanomaterial with tremendous potential in material [10][11][12] and medical 13,14 science given its unique physical, chemical, and mechanical properties. Recent studies have found great popularity for GO as a drug carrier, 14,15 imaging probe, 16 and biomedical device.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells

Zhao

Cui

et al. 2014

IJN

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The purpose of this study was to evaluate the cytotoxicity of human multiple myeloma cells (RPMI-8226) treated with graphene oxide (GO), doxorubicin (DOX), and GO loaded with DOX (GO/DOX). Cell viability was determined using the Cell Counting Kit-8 assay and analyzing the cell cycle and cell apoptosis. Cells treated with GO, GO/DOX, and pure DOX for 24 hours showed a decrease in proliferation. GO/DOX significantly inhibited cell proliferation as compared with pure DOX ( P <0.01). When the effects of GO were removed, there was no observed difference between GO/DOX and pure DOX ( P >0.05). Flow cytometry analysis of untreated and GO-, DOX-, and GO/DOX-treated cells found no significant differences in the G 0 /G 1 phase ( P >0.05), while significant differences were observed in the total apoptotic rates ( P <0.05). No significant differences existed in the total apoptotic rates of GO-treated and untreated cells ( P >0.05). These findings suggest that GO caused low cytotoxicity and did not induce cell apoptosis or change the cell cycle in multiple myeloma cells. Moreover, GO did not affect the antitumor activity of DOX. In conclusion, GO would be suitable as an anticancer drug nanocarrier and used to treat hematological malignancies.

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells

Zhao

Cui

et al. 2014

IJN

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“…[39][40][41][42][43][44][45][46] In particular, these polymer composites may play different roles in chemical sensors and biosensors besides providing mechanical stability and improving the nanoller dispersion, leading to enhanced sensitivity and selectivity. Although there are a number of recent reviews related to the use of CNTs and graphene in chemical sensors and biosensors, [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] to the best of our knowledge, there is no report devoted to carbon based polymer composites for this specic application (except for the just published work 47 related exclusively to conducting polymer-graphene composites for electrochemical sensors). This is the framework of the present revision in which the added value of incorporating polymers into these carbon nanomaterial based sensors is discussed.…”

Section: Marianmentioning

confidence: 99%

“…The fundamental aspects of graphene electrochemistry [28][29][30][31] as well as the room of graphene electrodes in sensing [32][33][34][35]37,[212][213][214] are beyond the scope of this review and the readers are directed to the aforementioned literature.…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Chemical sensors based on polymer composites with carbon nanotubes and graphene: the role of the polymer

et al. 2014

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“…As a result of the nanopores in the graphene plane, porous graphene exhibits properties distinct from those of pristine graphene, leading to its potential applications in numerous¯elds such as energy storage 13 gas puri¯-cation, 14,15 and DNA sequencing. 16,17 However, though many researchers have extensively studied graphene-related materials both experimentally and theoretically, almost all researches are focused on nanoelectronics, supercapacitors, multifunctional membrances, bio-applications or others. Then the questions are: Is R-GO porous or not?…”

Section: Introductionmentioning

confidence: 99%

The Changes of Absorption and Catalytic Capacity on Reduced Graphene Oxide After Electron Beam Irradiation

Liu

et al. 2015

NANO

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As is well-known, porous nanomaterials have attracted increasing attention recently, and graphene-related materials (such as porous graphene) have been studied both experimentally and theoretically. Almost all researches are focused on nanoelectronics, supercapacitors, multifunctional membrances, bio-applications or others. Consequently, in order to understand the di®er-ences between porous graphene and normal graphene at adsorption and catalytic property, in this experiment, with the removal of metal ion ( 152 Eu(III)) and organic matter (gallic acid) and reduction of 4-nitrophenol (4-NP) by NaBH 4 as model reactions, a systematic investigation into the adsorptive performance as well as catalytic activity of graphene with or without electron beam irradiation exposure had been carried out. As the results showed, compared with the reduction of pristine graphene oxidized (R-GO), the reduction of graphene oxidized with electron beam irradiation exposure (100 MGy, about 2 h, radiation graphene oxide (R-RGO)) had many irregular defects caused by lack of atoms; the adsorptive performance of the R-RGO increased for metals but decreased for organic matter. However, the adsorption rate of the R-RGO was lower for metals, but higher for organic matter than that of the R-GO. In addition, the results also showed that the R-RGO had a better catalytic capacity than the R-GO.

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Graphene–DNA hybrid materials: Assembly, applications, and prospects

Cited by 143 publications

References 120 publications

Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells

Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells

Chemical sensors based on polymer composites with carbon nanotubes and graphene: the role of the polymer

The Changes of Absorption and Catalytic Capacity on Reduced Graphene Oxide After Electron Beam Irradiation

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