Graphene Family Nanomaterials in Ocular Applications: Physicochemical Properties and Toxicity

Borandeh, Sedigheh; Alimardani, Vahid; Abolmaali, Samira Sadat; Seppälä, Jukka

doi:10.1021/acs.chemrestox.0c00340

Cited by 30 publications

(17 citation statements)

References 148 publications

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“…It was estimated that the concentrations of discharged NMs in the surface and effluent waters could reach μg/L levels (Giese et al 2018;Gottschalk et al 2009;Keller and Lazareva 2014). Labscale experiments have showed that NMs could induce oxidative damage or adsorb enzymes to interrupt the metabolic activity of organisms (Borandeh et al 2021;Nguyen et al 2018;Schultz et al 2012). Moreover, NMs could act as carriers to bring heavy metal ions or organic pollutants into organisms (Fan et al 2011).…”

Section: Introductionmentioning

confidence: 99%

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

et al. 2022

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Nanomaterials (NMs) are able to interact with natural organic matter (NOM) such that NOM is adsorbed on the surface of NMs to form an ecological corona (eco-corona). The formation of an eco-corona can greatly influence the behavior, risk and fate of NMs in the environment. A systematic understanding of the impacts of an eco-corona on the hazards of NMs is crucial for NMs risk assessment in the aquatic environment. Herein, the mechanisms of the formation of an eco-corona were reviewed based on the representative literatures and their generality was discussed on the basis of the type of NMs, the type of NOM and the environmental conditions. The effects of an eco-corona on the bioaccumulation and toxicity of NMs for aquatic organisms were systematically discussed through reported studies. The results showed that an eco-corona could alter the toxicity of NMs by changing the dissolution of NMs, adhesion of NMs and the damages to bio-membranes, internalization, and the generation of NMs-induced reactive oxygen species. The dual effects of an eco-corona on the toxicity/accumulation of NMs were widely present because of the complex molecular composition of NOM, the diverse types of NMs, and the variable environmental conditions. The effects of an eco-corona on the fate and the effects of other pollutants (such as metals and organic pollutants) were also carefully reviewed. The results showed that more research is needed to investigate the effect of an eco-corona through the development of novel techniques, mathematical modeling, and mesocosm studies. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

et al. 2022

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“…Furthermore, particles below 35 nm are able to cross the BBB. When graphene enters the cell, there is a potential to cause cell damage; this can perhaps be minimized through functionalization [ 108 ]. In the majority of cases, coating GO with biocompatible polymers helps improve its biocompatibility and reduce its toxicity [ 87 ].…”

Section: Graphene Oxide: Biocompatible or Cytotoxic?mentioning

confidence: 99%

Graphene Oxide Thin Films with Drug Delivery Function

et al. 2022

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Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.

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“…Furthermore, an increasing number of research groups devoted their attention to develop alternative MSCs mediated therapies. In this framework, many articles have reported on the combination of various approaches to resolve any resulted synergistic effect on cytotoxicity which remains a major clinical problem in tissue engineering [115,119,121].…”

Section: Graphene Family Combined With Human Mesenchymal Stem Cellsmentioning

confidence: 99%

Impact of Graphene Derivatives as Artificial Extracellular Matrices on Mesenchymal Stem Cells

et al. 2022

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Thanks to stem cells’ capability to differentiate into multiple cell types, damaged human tissues and organs can be rapidly well-repaired. Therefore, their applicability in the emerging field of regenerative medicine can be further expanded, serving as a promising multifunctional tool for tissue engineering, treatments for various diseases, and other biomedical applications as well. However, the differentiation and survival of the stem cells into specific lineages is crucial to be exclusively controlled. In this frame, growth factors and chemical agents are utilized to stimulate and adjust proliferation and differentiation of the stem cells, although challenges related with degradation, side effects, and high cost should be overcome. Owing to their unique physicochemical and biological properties, graphene-based nanomaterials have been widely used as scaffolds to manipulate stem cell growth and differentiation potential. Herein, we provide the most recent research progress in mesenchymal stem cells (MSCs) growth, differentiation and function utilizing graphene derivatives as extracellular scaffolds. The interaction of graphene derivatives in human and rat MSCs has been also evaluated. Graphene-based nanomaterials are biocompatible, exhibiting a great potential applicability in stem-cell-mediated regenerative medicine as they may promote the behaviour control of the stem cells. Finally, the challenges, prospects and future trends in the field are discussed.

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Graphene Family Nanomaterials in Ocular Applications: Physicochemical Properties and Toxicity

Cited by 30 publications

References 148 publications

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

A critical review on the biological impact of natural organic matter on nanomaterials in the aquatic environment

Graphene Oxide Thin Films with Drug Delivery Function

Impact of Graphene Derivatives as Artificial Extracellular Matrices on Mesenchymal Stem Cells

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