Graphene–Gold Metasurface Architectures for Ultrasensitive Plasmonic Biosensing

Zeng, Shuwen; Sreekanth, Kandammathe Valiyaveedu; Shang, Jingzhi; Yu, Ting; Chen, Chih‐Kuang; Yin, Feng; Baillargeat, Dominique; Coquet, Philippe; Ho, Ho-Pui; Kabashin, Andrei V.; Yong, Ken‐Tye

doi:10.1002/adma.201501754

Cited by 288 publications

(207 citation statements)

References 35 publications

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“…Laser light must be oriented in p-polarized mode so that the electrons' interaction between metal and dielectric will create SPPs oscillations due to the applied electromagnetic field [20]. Note that suitable types of metal thin film with appropriate thicknesses, usually 50nm also need to be considered [21].…”

Section: Introductionmentioning

confidence: 99%

Optimization of SPR signals: Monitoring the physical structures and refractive indices of prisms

Mukhtar

Halim²,

Hassan

2017

EPJ Web Conf.

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Abstract. Surface plasmon resonance (SPR) can only be achieved if sufficient energy is provided at the boundary between metal and dielectric. An employment of prism as a light coupler by using Kretschmann configuration is one of the alternative for the production of adequate energy to be generated as surface plasmon polaritons (SPP). This work is carried out to investigate the effect of physical structure of the prism and its refractive index to the excitation of SPPs. A 50nm gold thin metal film with dielectric constant of ε=-12.45i+1.3 was deposited on the hypotenuse surface of the prisms. The physical structures of the prisms were varied such as triangular, conical, hemispherical and half cylindrical. These prisms were classified into two types of refractive indices (RI), namely n=1.51(type BK7) and n=1.77(type SF11). Based on SPR curve analyses, we discovered that strong SPR signals which consist of 82.98% photons were excited as SPPs can be obtained by using type-BK7 prism with physical structures of hemispherical or half cylindrical. From the view of selectivity ability as sensors, the usage of type-SF11 prisms (half cylindrical and hemispherical) able to enhance this impressive feature in which sharp SPR curves with small FWHM values were obtained. In conclusion, apart from properties of thin film materials, the physical structure of prisms and their RI values play crucial roles to obtain optimum SPR signal. High sensitivity SPR sensor can be established with the appointment of type-BK7 prisms (hemispherical or half cylindrical shape) as light couplers.

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Section: Introductionmentioning

confidence: 99%

Optimization of SPR signals: Monitoring the physical structures and refractive indices of prisms

Mukhtar

Halim²,

Hassan

2017

EPJ Web Conf.

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“…On the other hand, LSP-based sensors perform well in some instances, particularly for smaller molecule detection, by precisely tracking the local refractive index changes due to biomolecular reactions by using the concept of optical phase flips 11 . Recent progress in microfabrication and nanofabrication has encouraged the development of novel labelfree plasmonic biosensors, particularly metamaterials, which can overcome the limitations of conventional plasmonic sensors [12][13][14][23][24][25][26] . A metamaterial based on two-dimensional (2D) porous gold nanorod arrays has also been proposed for high-sensitivity plasmonic biosensors 14 .…”

mentioning

confidence: 99%

Extreme sensitivity biosensing platform based on hyperbolic metamaterials

Sreekanth¹,

Alapan²,

ElKabbash³

et al. 2016

Nature Mater

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682

529

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Optical sensor technology offers significant opportunities in the field of medical research and clinical diagnostics, particularly for the detection of small numbers of molecules in highly diluted solutions. Several methods have been developed for this purpose, including label-free plasmonic biosensors based on metamaterials. However, the detection of lower-molecular-weight (<500 Da) biomolecules in highly diluted solutions is still a challenging issue owing to their lower polarizability. In this context, we have developed a miniaturized plasmonic biosensor platform based on a hyperbolic metamaterial that can support highly confined bulk plasmon guided modes over a broad wavelength range from visible to near infrared. By exciting these modes using a grating-coupling technique, we achieved different extreme sensitivity modes with a maximum of 30,000 nm per refractive index unit (RIU) and a record figure of merit (FOM) of 590. We report the ability of the metamaterial platform to detect ultralow-molecular-weight (244 Da) biomolecules at picomolar concentrations using a standard affinity model streptavidin-biotin.

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“…Furthermore, the high confinement of the electromagnetic field associated with SPs means that they can only sense changes in *e-mail: giuseppe.strangi@case.edu the dielectric constant that take place near their interface, allowing them to ''see'' only biomolecules that are captured by the bio-receptors. SPP sensors are usually built in a Kretschmann configuration that matches momentum between the surface plasmon and a laser beam, whereas LSP sensors exhibit a tunable resonant frequency that does not require momentum matching [7,8]. LSP sensors geometrically confine electromagnetic energy absorbed from large optical crosssections to significantly enhance local fields within 5-15 nm of the nanoparticle surface [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Hyperbolic metamaterials-based plasmonic biosensor for fluid biopsy with single molecule sensitivity

Sreekanth

ElKabbash

Alapan

et al. 2017

EPJ Applied Metamaterials

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-Plasmonic sensors are one of the most powerful optical biosensors, which can be used for the detection of small numbers of molecules at ultra-low concentrations. However, the detection of dilute analytes of low molecular weight (<500 Da) is still a challenging task using currently available plasmonic biosensors. Here, we demonstrate the detection of both lower and heavier molecular weight biomolecules close to single molecule level using a novel plasmonic biosensor platform based on hyperbolic metamaterials. We show experimentally the extraordinary spectral and angular sensitivities of the biosensor platform, from visible to near infrared (NIR) wavelengths, by exciting the bulk plasmon polaritons associated with hyperbolic metamaterials.

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Graphene–Gold Metasurface Architectures for Ultrasensitive Plasmonic Biosensing

Cited by 288 publications

References 35 publications

Optimization of SPR signals: Monitoring the physical structures and refractive indices of prisms

Optimization of SPR signals: Monitoring the physical structures and refractive indices of prisms

Extreme sensitivity biosensing platform based on hyperbolic metamaterials

Hyperbolic metamaterials-based plasmonic biosensor for fluid biopsy with single molecule sensitivity

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