Graphene‐mesoporous anatase TiO₂ nanocomposite: A highly efficient and recyclable heterogeneous catalyst for one‐pot multicomponent synthesis of benzodiazepine derivatives

Abstract

The potential to bias chemical reaction pathways is a significant goal for physicists and material researchers to design revolutionary materials.Recently, two-dimensional materials have appeared as a promising candidate for exploring novel catalyst activity in organic reaction. In this context, herein we report an easy and efficient synthesis of substituted benzodiazepines in high yields through the graphene-based mesoporous TiO 2 nanocomposite (Gr@TiO 2 NCs) catalyst. To validate the merits of the Gr@TiO 2 NCs as a catalyst, we have also designed TiO 2 nanoparticle (NPs) under similar conditions. Successful comprehension realization of Gr@TiO 2 NCs and TiO 2 NPs were concluded from the XRD, SEM, HR-TEM, EDS elemental mapping, FT-IR, Raman, UV-Vis and TGA analysis. Gr@TiO 2 NCs has the propitious catalyst performance (~98%) over the TiO 2 NPs (~77%), which could be scrutinized in terms of graphene support toward the TiO 2 NPs and enable the large contact area between graphene and TiO 2 NPs. Incorporated graphene maintaining TiO 2 as a catalytically active and attracting electron to site isolation, as well as protecting TiO 2 from oxidative degradation during the reaction. Moreover, the role of graphene is suggested to prolonged reaction duration, yield and unaltered throughout the reaction because of the π-π interaction between graphene and TiO 2 NPs. Additionally, the catalyst is recycled by filtration and reprocessed six times without having a significant loss in its catalytic activity.

An efficient CuO/rGO/TiO2photocatalyst for the synthesis of benzopyranopyrimidine compounds under visible light irradiation

“…5c). 48 The broad band in the 600–800 cm −1 range and specifically at 653 cm −1 is assigned to the Ti–O–C bond, 49 which confirms a good interaction of TiO 2 NPs with the rGO surface in the rGO/TiO 2 composite. The characteristic peak at 632 cm −1 (Fig.…”

Discovery of a novel oxadiazine derivative of glucocorticoids endowed with DNA binding activities and molecular docking studies

“…It has been shown in recent studies that incorporation of heteroatoms (N/O/S) enhances the biological activities of steroid molecules [1][2][3][4][5]. It was proved by various in vivo and in vitro assays which show significant antimicrobial, anti-inflammatory, hypotensive, hypocholesterolemic and diuretic activities [6][7][8][9][10][11][12][13][14][15]. Similarly, such effects have been shown by the most commonly used systemic glucocorticoids such as hydrocortisone, prednisolone and triamcinolone.…”

Recent advancements in organic synthesis catalyzed by graphene oxide metal composites as heterogeneous nanocatalysts

“…Graphene is a two‐dimensional crystal that can be considered as the basic building block for carbon materials. It is a hexagonal flat layer of carbon used in the areas of catalysis, physics, material science, super capacitors, [ 6,7 ] tissue engineering, [ 8–10 ] solar cells, [ 11–14 ] fuel‐cells, [ 15,16 ] water‐purification, [ 17–20 ] sensors, [ 21,22 ] gas adsorption, [ 23–25 ] synthesis, [ 26–29 ] and medicine, [ 30,31 ] hydrogen storage and field emitters, chemistry, and so forth. Being green and amazing catalyst support, it is an excellent option for the applications because of the high immobilization of metal and metal oxide nanoparticles on its surface and between its layers to prepare highly efficient heterogeneous catalyst.…”