Graphene nanoparticles as pseudostationary phase for the electrokinetic separation of nonsteroidal anti‐inflammatory drugs

Abstract

The exceptional properties of graphene (G) were exploited here to facilitate capillary electrokinetic separations. Two types of commercially available G consisting of nanoparticles containing-one to three and-four to six G sheets, respectively, were compared for this purpose. Both proved effective in separating the arylpropyl derivatives of nonsteroidal anti-inflammatory drugs. The highest resolution and shortest migration times were obtained with G containing high amount of single and double G nanosheets. G affords higher resolution than other types of nanoparticles; stable suspensions can be easily prepared and used as BGE without the need of adding an additional surfactant. This results in a high reproducibility in migration times and stability in background noise. The LOD and LOQ obtained by using G nanoparticles as pseudostationary phases spanned the range 0.29-1.18 mg/L and 0.95-3.95 mg/L, respectively, and the RSD was less than 4.7% in all instances.

Carbon Dot-Mediated Capillary Electrophoresis Separations of Metallated and Demetallated Forms of Transferrin Protein

“…Many recent applications involving CDs capitalize on their fluorescent properties for bioimaging [8,9,10,11], biomedicine [12], and biosensing [13,14,15] to aid in the diagnosis and treatments of diseases, defects, and cancers [1]. However, little is known about the utility of CDs as separation adjuvants in capillary electrophoresis (CE) [3] in comparison to other nanomaterials such as silica nanoparticles [16,17], carbon nanotubes [18], graphene nanoparticles [19], single-walled carbon nanotubes [20], and gold nanoparticles [21,22,23], which have all been reported to enhance CE separations.…”

Polyethylene Glycols for the Dispersion Development of Graphene in an Aqueous Surfactant Solution Studied by Affinity Capillary Electrophoresis

“…[1][2][3] Graphene nanoparticles were used as a stationary phase for the electrokinetic separation of nonsteroidal antiinflammatory drugs. 4 A silica capillary was coated with graphene oxide for the chiral separation of ephedrine and pseudoephedrine without any chiral selector. 5 The stationary phase of grafted glycidyl methacrylate for capillary electrochromatography was covalently modified with graphene oxide, and the capillary column was used for chiral separations of naproxen, warfarin, and pranoprofen with methyl-βcyclodextrin as a chiral selector.…”

Graphene oxide‐SiO2 hybrid nanostructure as coating material for capillary electrochromatography

“…As a novel 2D material with exceptional electronic, mechanical, thermal, and optical properties, graphene has attracted tremendous attention in recent years . In separation science, both graphene oxide (GO) and reduced graphene oxide (G) are being considered as promising stationary phases for chromatography separation due to their ultrahigh specific surface area and large delocalized π‐electron system . Because the aggregated graphene nanosheets are not mechanically strong enough to withstand the high pressure generated in the packing process, they cannot be used directly as packing materials for chromatography separation.…”