Graphene Nanopore with a Self-Integrated Optical Antenna

Nam, SungWoo; Choi, Inhee; Fu, Chi Cheng; Kim, Kwanpyo; Hong, Soongweon; Choi, Yeonho; Zettl, A.; Lee, Luke P.

doi:10.1021/nl503159d

Cited by 84 publications

(90 citation statements)

References 42 publications

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“…Yet another alternative is to use plasmonics to control a DNA molecule in a nanopore [125,126]. In this approach, gold nanoantennas around a graphene nanopore are used to trap the DNA in a plasmonic hotspot right at the pore, introducing a "physical knob" to switch the motion of the DNA through the pore on or off.…”

Section: Discussionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade as it will pave the way for personalised medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established including sequencing with nanopores. Due to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

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Section: Discussionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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“…These nanopores have been created in a range of materials from graphene [17][18][19][20] , polymers 21 , silicon nitride 22 and glass 13,14,23,24 . The transport of the ions or analyte through the channel can by controlled by tuning the applied potential, pore wall charge, pore size, supporting electrolyte concentration and composition, with a further degree of selectivity by modifying the pore walls with selective ligands [25][26][27] .…”

Section: Introductionmentioning

confidence: 99%

Protein detection using tunable pores: resistive pulses and current rectification

et al. 2016

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We present the first comparison between assays that use resistive pulses or rectification ratios on a tunable pore platform. We compare their ability to quantify the cancer biomarker Vascular Endothelial Growth Factor (VEGF). The first assay measures the electrophoretic mobility of aptamer modified nanoparticles as they traverse the pore. By controlling the aptamer loading on the particle surface, and measuring the speed of each translocation event we are able to observe a change in velocity as low as 18 pM. A second non-particle assay exploits the current rectification properties of conical pores. We report the first use of Layer-by-Layer (LbL) assembly of polyelectrolytes onto the surface of the polyurethane pore. The current rectification ratios demonstrate the presence of the polymers, producing pH and ionic strength-dependent currents. The LbL assembly allows the facile immobilisation of DNA aptamers onto the pore allowing a specific dose response to VEGF. Monitoring changes to the current rectification allows for a rapid detection of 5 pM VEGF. Each assay format offers advantages in their setup and ease of preparation but comparable sensitivities.

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“…Our choice was also influenced by the number of techniques that enable the introduction of nanoscale pores of arbitrary size and location to graphene, including both electron-beam bombardment and chemical approaches. [30][31][32][33][34][35][36][37][38][39] These techniques will ultimately provide flexibility and precision in pattern shape and scale, including precise hole size and pitch.…”

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confidence: 99%

Holey Graphene as a Weed Barrier for Molecules

et al. 2015

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We demonstrate the use of "holey" graphene as a mask against molecular adsorption. Prepared porous graphene is transferred onto a Au{111} substrate, annealed, and then exposed to dilute solutions of 1-adamantanethiol. In the pores of the graphene lattice, we find islands of organized, self-assembled molecules. The bare Au in the pores can be regenerated by postdeposition annealing, and new molecules can be self-assembled in the exposed Au region. Graphene can serve as a robust, patternable mask against the deposition of self-assembled monolayers.

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Graphene Nanopore with a Self-Integrated Optical Antenna

Cited by 84 publications

References 42 publications

Graphene nanodevices for DNA sequencing

Graphene nanodevices for DNA sequencing

Protein detection using tunable pores: resistive pulses and current rectification

Holey Graphene as a Weed Barrier for Molecules

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