Graphene nanosheet mediated MALDI-MS (GN-MALDI-MS) for rapid, in situ detection of intact incipient biofilm on material surfaces

Wu, Bo Sgum; Gopal, Judy; Hua, Pei-Yang; Wu, Hui‐Fen

doi:10.1016/j.msec.2016.04.053

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…The DESI MS method is direct and rapid in providing molecular detail of the surfaces studied; however, it requires the development and optimization of novel ionization strategies for the ionization of tough ionizing molecules. LDI MS techniques have evolved to use nanomaterials to assist in fine-tuning the technique [103][104][105][106][107][108]; applications of this technique could certainly prove beneficial with respect to MP detection. MS-based techniques are still confronting reproducibility issues and lapses in quantification methodologies-these need to be overcome in order to fully utilize these techniques.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Chun

Muthu²,

Gopal³

2022

Chemosensors

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Plastic particles smaller than 5 mm accumulate in aqueous, terrestrial, and atmospheric environments and their discovery has been a serious concern when it comes to eco-toxicology and human health risk assessment. In the following review, the potential of mass spectrometry (MS) for the detection of microplastic (MP) pollutants has been elaborately reviewed. The use of various mass spectrometric techniques ranging from gas chromatography–mass spectrometry (GC-MS), liquid chromatographic mass spectrometric (LC-MS) to matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), including their variants, have been reviewed. The lapses in the detection system have been addressed and future recommendations proposed. The challenges facing microplastics and their detection have been discussed and future directions, including mitigation methods, have been presented.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Chun

Muthu²,

Gopal³

2022

Chemosensors

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Magnetic carbon nanocomposites as a MALDI co-matrix enhancing MS-based glycomics

et al. 2018

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More than 50% of all known proteins are glycosylated, which is critical for many biological processes such as protein folding and signal transduction. Glycosylation has proven to be associated with different mammalian diseases such as breast and liver cancers. Therefore, characterization of glycans is highly important to facilitate a better understanding of the development and progression of many human diseases. Although matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) offers several advantages such as ease of operation and short analysis times, however, due to the complexity of glycan structures and their low ionization efficiency, there are still challenges that need to be addressed to achieve sensitive glycan analysis. Here, magnetic carbon nanocomposites (CNPs@FeO NCs) were used as a new MALDI matrix or co-matrix for the analysis of glycans derived from different model glycoproteins and human blood serum samples. The addition of CNPs@FeO NCs to the matrix significantly enhanced glycan signal intensity by several orders of magnitude, and effectively controlled/reduced/eliminated in-source decay (ISD) fragmentation. The latter was attained by modulating CNPs@FeO NCs concentrations and allowed the simultaneous study of intact and fragmented glycans, and pseudo-MS analysis. Moreover, CNPs@FeO NCs was also effectively employed to desalt samples directly on MALDI plate, thus enabling direct MALDI-MS analysis of unpurified permethylated glycans derived from both model glycoproteins and biological samples. On-plate desalting enhanced sensitivity by reducing sample loss. Graphical abstract ᅟ.

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Two-dimensional boron nanosheets for selective enrichment and detection of cis-diol compounds by surface-assisted laser desorption/ionization time-of-flight mass spectrometry

Wang

Qin

Zheng

et al. 2023

Journal of Chromatography A

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Graphene nanosheet mediated MALDI-MS (GN-MALDI-MS) for rapid, in situ detection of intact incipient biofilm on material surfaces

Cited by 6 publications

References 42 publications

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Magnetic carbon nanocomposites as a MALDI co-matrix enhancing MS-based glycomics

Two-dimensional boron nanosheets for selective enrichment and detection of cis-diol compounds by surface-assisted laser desorption/ionization time-of-flight mass spectrometry

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