Graphene-Oxide and Ionic Liquid Modified Electrodes for Electrochemical Sensing of Breast Cancer 1 Gene

Isin, D. K.; Ekşin, Ece; Erdem, Arzum

doi:10.3390/bios12020095

Cited by 15 publications

(8 citation statements)

References 55 publications

(114 reference statements)

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“…Subsequently, it was employed for the determination of ACL and CL in human serum samples. In another study, Isin and colleagues developed an electrochemical biosensor using a GO and IL (BMIM HFP) modified pencil graphite electrode (PGE) for the detection of the breast cancer 1 gene (BRC) [ 159 ]. Initially, the PGE (electrochemically activated) surface was modified by dipping it in the IL-GO solution (7.5% IL) for 15 min., then dried in an open atmosphere to obtain IL-GO/PGE.…”

Section: Various Nanomaterial-modified Electrodesmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which monitor the target analytes in a continuous environment and alert the intended users to anomalies. The stability and performance of the developed biosensor depend on the nature and properties of the electrode material or the platform on which the biosensor is constructed. Therefore, the biosensor platform plays an integral role in the effectiveness of the developed biosensor. Enormous effort has been dedicated to the rational design of the electrode material and to fabrication strategies for improving the performance of developed biosensors. Every year, in the search for multifarious electrode materials, thousands of new biosensor platforms are reported. Moreover, in order to construct an effectual biosensor, the researcher should familiarize themself with the sensible strategies behind electrode fabrication. Thus, we intend to shed light on various strategies and methodologies utilized in the design and fabrication of electrochemical biosensors that facilitate sensitive and selective detection of significant analytes. Furthermore, this review highlights the advantages of various electrode materials and the correlation between immobilized biomolecules and modified surfaces.

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Section: Various Nanomaterial-modified Electrodesmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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“…ILs have found yet another application in cancer diagnosis, as they are incorporated into graphene-oxide and IL composite-modified pencil graphite electrodes (GO-IL-PGEs), a novel biosensing platform developed for the first time [79]. GO-IL-PGEs were applied for electrochemical detection of the breast cancer 1 (BRCA1) gene.…”

Section: Ils In Cancer Diagnosismentioning

confidence: 99%

Unlocking the Anticancer Potential of Ionic Liquids

Mohd Noor,

Elgharbawy,

Moniruzzaman

et al. 2023

ChemBioEng Reviews

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Despite advances in cancer treatment, many types of cancer still have high mortality rates, and the existing therapies can cause considerable side effects. Therefore, discovering new therapies, especially ones with fewer side effects, is desirable to improve the outcomes for cancer patients. Ionic liquids (ILs) have emerged as potential candidates for cancer treatment because of their particular physicochemical properties, which can be tailored for specific applications. In recent years, interest in exploring the potential of ILs in cancer treatment has been growing, and several studies have demonstrated the effectiveness of ILs in inhibiting cancer‐cell growth. This review provides insight into the anticancer potential of ILs, exploring the diverse applications and the underlying mechanisms behind the cytotoxicity toward cancer cells of ILs. Understanding the mechanisms behind the cytotoxicity of ILs can aid in the design and optimization of IL‐based cancer therapies. By focusing on specific pathways and targets, IL‐based cancer therapies may be developed that offer new possibilities for treating this devastating disease.

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“…For electrochemical detection systems, the electrochemical performance of the CNF-IL composite material, which is formed by combining the advantages of IL and CNF, provides a remarkable increase. For this reason, the number of ionic liquid/nanomaterial composite applications in electrochemical analysis has been recently increasing day by day [ 5 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, very small changes before/after the biointeraction process can be detected easily and quickly via EIS-based biosensors at the electrode surface [ 70 , 71 ]. Therefore, it is very necessary to improve its selectivity by replacing the electrode surface with a specific substance that can interact specifically with the analytes [ 23 , 68 ]. In one of our earlier studies [ 61 ], dendrimer modified impedimetric aptasensor was designed and applied to detect the interaction of APC-specific DNA aptamer (DNA-Apt) with its target protein, activated protein C. Koyun et al [ 28 ], developed a highly sensitive and selective label-free aptasensor for the specific detection of human activated protein C by surface plasmon resonance method.…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanofiber-Ionic Liquid Nanocomposite Modified Aptasensors Developed for Electrochemical Investigation of Interaction of Aptamer/Aptamer–Antisense Pair with Activated Protein C

Maral

Erdem

2023

Biosensors

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Selective and sensitive detection of human activated protein C (APC) was performed herein by using carbon nanofiber (CNF) and ionic liquid (IL) composite modified pencil graphite electrode (PGE) and electrochemical impedance spectroscopy (EIS) technique. A carbon nanomaterial-based electrochemical aptasensor was designed and implemented for the first time in this study for the solution-phase interaction of DNA-Apt with its cognate protein APC as well as APC inhibitor aptamer–antidote pair. The applicability of this assay developed for the determination of APC in fetal bovine serum (FBS) and its selectivity against different proteins (protein C, thrombin, bovine serum albumin) was also examined. CNF-IL modified aptasensor specific to APC provided the detection limit as 0.23 μg/mL (equal to 3.83 nM) in buffer medium and 0.11 μg/mL (equal to 1.83 nM) in FBS. The duration of the proposed assay from the point of electrode modification to the detection of APC was completed within only 55 min.

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Graphene-Oxide and Ionic Liquid Modified Electrodes for Electrochemical Sensing of Breast Cancer 1 Gene

Cited by 15 publications

References 55 publications

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Unlocking the Anticancer Potential of Ionic Liquids

Carbon Nanofiber-Ionic Liquid Nanocomposite Modified Aptasensors Developed for Electrochemical Investigation of Interaction of Aptamer/Aptamer–Antisense Pair with Activated Protein C

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