Graphene oxide aptasensor droplet assay for detection of metabolites secreted by single cells applied to synthetic biology

Zheng, Dan; Zhang, Jingyun; Jiang, Wenxin; Xu, Ying; Meng, Haixu; Poh, Chueh Loo; Chen, Chia-Hung

doi:10.1039/d3lc00959a

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2024

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Cited by 2 publications

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“…26 It is noticeable that CQDs could be modified with some enhancing element, such as graphene, gold spheres or gold rods. 55,56 In future studies, it is worth testing if the functionalization would facilitate the binding of the receptor as well as sensitivity further. On the other hand, the receptor is expressed in E. coli , which makes it easy to carry out protein engineering.…”

Section: Resultsmentioning

confidence: 99%

A miniprotein receptor electrochemical biosensor chip based on quantum dots

Zhao,

Han,

Huang

et al. 2024

Lab Chip

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Section: Resultsmentioning

confidence: 99%

A miniprotein receptor electrochemical biosensor chip based on quantum dots

Zhao,

Han,

Huang

et al. 2024

Lab Chip

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Aptasensors and Advancement in Molecular Recognition Technology

Napit,

Jaysawal,

Chowdhury

et al. 2024

Adv Materials Technologies

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Synthetic oligonucleic acids known as aptamers exhibit remarkable selectivity and affinity for target recognition and binding. Selected via an iterative process known as “selective evolution of ligands by exponential enrichment” (SELEX), aptamers fold into defined 3D conformations to interact with their targets. The incorporation of aptamers as recognition elements has driven notable progress in biosensors, giving rise to the development of aptasensors. Here, the process of aptamer discovery and the development of various types of aptasensors are summarized. The fundamental design principles of aptasensors are elaborated along with the superiority of aptamers compared to antibodies. The various modes employed by aptasensors, such as structure‐switching design, hybridization chain reaction amplification, enzyme‐assisted recycling, and split aptamer design are examined. Further light is shed on the diverse landscape of aptasensors, their adaptability to different analytes aptasensors as well as their potential to propel advancements in modern biosensor technology. As a nucleic acids‐based biosensor platform, aptasensors poise to become a next generation of sensitive and cost‐effective technology to shape the future of molecular recognition in biosensing.

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Graphene oxide aptasensor droplet assay for detection of metabolites secreted by single cells applied to synthetic biology

Abstract: A modifiable droplet graphene oxide (GO) aptasensor has been developed for low-background detection of various target compounds with enhanced signal-to-noise ratios for synthetic biology applications.

Cited by 2 publications

References 49 publications

A miniprotein receptor electrochemical biosensor chip based on quantum dots

A miniprotein receptor electrochemical biosensor chip based on quantum dots

Aptasensors and Advancement in Molecular Recognition Technology

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