Graphene Oxide Assisted Fluorescent Chemodosimeter for High-Performance Sensing and Bioimaging of Fluoride Ions

Abstract

Fluorescent chemodosimeters for a fluoride ion (F(-)) based on a specifically F(-)-triggered chemical reaction are characterized by high selectivity. However, they are also subjected to intrinsic limits, such as long response time, poor stability under aqueous solution, and unpredictable cell-member penetration. To address these issues, we reported here that the self-assembly of fluorescent chemodosimeter molecules on a graphene oxide (GO) surface can solve these problems by taking advantage of the excellent chemical catalysis and nanocarrier functions of GO. As a proof of concept, a new F(-)-specific fluorescent chemodosimeter molecule, FC-A, and the GO self-assembly structure of GO/FC-A were synthesized and characterized. Fluorescent sensing and imaging of F(-) with FC-A and GO/FC-A were performed. The results showed that the reaction rate constant of GO/FC-A for F(-) is about 5-fold larger than that of FC-A, so that the response time was shortened from 4 h to about 30 min, while for F(-), the response sensitivity of GO/FC-A was >2-fold higher than that of FC-A. Furthermore, GO/FC-A showed a better bioimaging performance for F(-) than FC-A because of the nanocarrier function of GO for cells. It is demonstrated that this GO-based strategy is feasible and general, which could help in the exploration of the development of more effective fluorescent nanodosimeters for other analytes of interest.

Novel 2,1,3-benzothiadiazole derivatives used as selective fluorescent and colorimetric sensors for fluoride ion

“…And they showed a faster response (within 5s) to fluoride ion than that of some related literatures. [27][28] …”

Strong hydrophobic interaction between graphene oxide and supported lipid bilayers revealed by AFM

“…Graphene‐related nanomaterials are believed to have great potential in applications in the fields of biology and biomedicine (Liu et al, , ; Sanchez et al, ; Sun et al, ; Wang et al, ; Yi and Gao, ), and have been used for biosensors (Ali et al, ; Ang et al, ; Liu et al, ; Qing et al, ), antibacterials (Dallavalle et al, ; Duan et al, ; Li et al, ; Mao et al, ; Pham et al, ; Pykal et al, ; Tu et al, ), bioimaging (Qian et al, ; Shi et al, ; Sun et al, ; Wang et al, ), regulation of cell growth and differentiation (Lee et al, ; Ruiz et al, ). Recently, the interaction between graphene oxide (GO) and cell membranes, including supported lipid bilayers (SLBs), has become the focus of many researchers (Frost et al, ; Furukawa and Hibino, ; Lei et al, ; Li et al, a,b; Okamoto et al, ; Phan et al, ; Rui et al, ; Wu et al, ) not only because cell membrane is the first barrier when GO interacts with intracellular components, but also it can provide us valuable information on physicochemical nature of GO.…”

Functionalization of 2D Materials with Photosensitive Molecules: From Light‐Responsive Hybrid Systems to Multifunctional Devices

“…The high fluorescence of the azobenzene–GO hybrid demonstrates that the two systems interact predominantly via electrostatic interactions rather than π–π stacking, which would lead to the quenching of the fluorescence. On this view, π–π interactions might be exploited to physically tether onto the surface of 2D materials possessing an extended π‐conjugation, such as graphene, a broad range of photoresponsive molecules including spiropyran derivatives, metal complexes, perylene diimides, and coumarin derivatives, for several different applications spanning from (bio)sensing to optoelectronics. The perylene diimide derivatives have also been used as surfactants for the exfoliation of graphene nanosheets .…”