Graphene oxide-based fluorescent biosensors and their biomedical applications in diagnosis and drug discovery

Yim, Yeajee; Shin, Hojeong; Ahn, Seong Min; Min, Dal‐Hee

doi:10.1039/d1cc02157e

Cited by 28 publications

(18 citation statements)

References 122 publications

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“…Due to their exceptional properties, GO-based materials are nowadays investigated as biosensors [ 15 ], antibacterial agents [ 16 ], in photothermal therapy (PTT) [ 17 ], as gene delivery systems [ 18 ], and for applications in tissue engineering and regenerative medicine [ 19 ] ( Figure 2 A). Among all their potential functions, GO- and rGO-based scaffolds have particularly attracted attention because of their great clinical projection in tissue regeneration therapies, making them very promising candidates in this field ( Table 1 ).…”

Section: Biomedical Applications Of Gomentioning

confidence: 99%

Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation

et al. 2022

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Due to its exceptional physical properties, such as high electronic conductivity, good thermal stability, excellent mechanical strength, and chemical versatility, graphene has sparked a lot of interest in the scientific community for various applications. It has therefore been employed as an antibacterial agent, in photothermal therapy (PTT) and biosensors, in gene delivery systems, and in tissue engineering for regenerative purposes. Since it was first discovered in 1947, different graphene derivatives have been synthetized from pristine graphene. The most adaptable derivate is graphene oxide (GO). Owing to different functional groups, the amphiphilic structure of GO can interact with cells and exogenous or endogenous growth/differentiation factors, allowing cell adhesion, growth, and differentiation. When GO is used as a coating for scaffolds and nanomaterials, it has been found to enhance bone, chondrogenic, cardiac, neuronal, and skin regeneration. This review focuses on the applications of graphene-based materials, in particular GO, as a coating for scaffolds in bone and chondrogenic tissue engineering and summarizes the most recent findings. Moreover, novel developments on the immunomodulatory properties of GO are reported.

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Section: Biomedical Applications Of Gomentioning

confidence: 99%

Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation

et al. 2022

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“…Notably, the GO bandgap is generated by the introduction of various functional groups, resulting in sp 2 and sp 3 hybridized carbon atoms. In addition, tuning the ratio of sp 2 and sp 3 hybridized carbon shifts the visible fluorescence to the near-infrared (NIR) wavelength [34]. Similar to GO, GQDs also have the same fluorescence properties via the doping process, which modulates the nature of the electronic properties and fluorescence.…”

Section: Origin Of Fluorescence In Graphene-based Nanomaterials and T...mentioning

confidence: 99%

“…Graphene-based nanomaterials are composed of sp 2 and sp 3 hybridized carbons by the introduction of functionality, which provides an optical bandgap that leads to fluorescence [1][2][3][4][5][6][7][8][9]. In particular, GO is rich in oxygen functionality and can lead to the partial reduction of GO-containing functional groups to produce rGO.…”

Section: Introductionmentioning

confidence: 99%

Role of Förster Resonance Energy Transfer in Graphene-Based Nanomaterials for Sensing

et al. 2022

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Förster resonance energy transfer (FRET)-based fluorescence sensing of various target analytes has been of growing interest in the environmental, bioimaging, and diagnosis fields. Graphene-based zero- (0D) to two-dimensional (2D) nanomaterials, such as graphene quantum dots (GQDs), graphene oxide (GO), reduced graphene oxide (rGO), and graphdiyne (GD), can potentially be employed as donors/acceptors in FRET-based sensing approaches because of their unique electronic and photoluminescent properties. In this review, we discuss the basics of FRET, as well as the role of graphene-based nanomaterials (GQDs, GO, rGO, and GD) for sensing various analytes, including cations, amino acids, explosives, pesticides, biomolecules, bacteria, and viruses. In addition, the graphene-based nanomaterial sensing strategy could be applied in environmental sample analyses, and the reason for the lower detection ranges (micro- to pico-molar concentration) could also be explained in detail. Challenges and future directions for designing nanomaterials with a new sensing approach and better sensing performance will also be highlighted.

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“…[13][14][15][16] As graphene was oxidized to its oxide form, graphene oxide (GO) was commonly used in electronic, energy, biomedicine, etc. [17][18][19][20][21][22][23] After using the GO, the agglomeration would be remitted to a large degree. GO was an interlaminar graphite compound produced by interlaminar oxidation of graphite under the joint action of the strong acid and oxidant.…”

Section: Introductionmentioning

confidence: 99%

“…For example, graphene exhibited poor compatibility and dispersion when it was composited with the polymer to form agglomeration in the polymer matrix, which would damage the performance of the polymer 13–16 . As graphene was oxidized to its oxide form, graphene oxide (GO) was commonly used in electronic, energy, biomedicine, etc 17–23 . After using the GO, the agglomeration would be remitted to a large degree.…”

Section: Introductionmentioning

confidence: 99%

Properties study of composites for polybutene‐1 and modified graphene oxide

Kou

Duan

Chen

et al. 2022

J of Applied Polymer Sci

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Polybutene-1 (PB-1) was wildly used as pipe and film with its excellent mechanical performance, great creep resistance even at high temperature, good machinability, and fillable performance. This work focused on studying the properties of composites for polybutene-1 and modified graphene oxide (MGO). The graphene oxide (GO) was prepared using an improved Hummers method, and then it was modified with γ-methylacryloxy propyl trimethoxysilane (KH570). After that, the obtained MGO was composited with PB-1 by the solution blending method. The structure and properties of PB-1 composites were investigated by Fourier transform infrared (FTIR), scanning electron microscope (SEM), Xray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimeter (DSC), universal material testing machine. The results showed that the MGO and PB-1 presented good compatibility, and the addition of MGO could not change the crystal morphology of PB-1. When the content of MGO was 0.75 wt% of PB-1, the melt and crystallization temperatures were 127.5 and 70.5 C, and the strength of tensile and bending in the PB-1/MGO composites was 27.58 and 674 MPa. Thus, the PB-1/MGO composites have great potential for practical applications, such as in agricultural films and tubes.

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Graphene oxide-based fluorescent biosensors and their biomedical applications in diagnosis and drug discovery

Abstract: Graphene oxide (GO), an oxidized derivative of graphene, has received much attention for developing novel fluorescent bioanalytic platforms due to its remarkable optical properties and biocompatibility. The reliable performance and...

Cited by 28 publications

References 122 publications

Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation

Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation

Role of Förster Resonance Energy Transfer in Graphene-Based Nanomaterials for Sensing

Properties study of composites for polybutene‐1 and modified graphene oxide

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