Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

Ghawanmeh, Abdullah A.; Ali, Gomaa A. M.; Algarni, H.; Sarkar, Shaheen M.

doi:10.1007/s12274-019-2300-4

Cited by 114 publications

(46 citation statements)

References 227 publications

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“…The phenomenon of protein adsorption on a polymer membrane is seen in a wide variety of applications . The applications include tissue engineering applications both in vitro and in vivo , biophysics, pharmaceutical sciences, and sensors . The phenomenon is realized in many industrial applications such as protein purification/separation, solid‐phase immunoassay, chromatography, and filtration .…”

Section: Introductionmentioning

confidence: 99%

Protein–polymer interaction: Transfer loading at interfacial region of PES‐based membrane and BSA

Sadegh

Sahay

Soni

2019

J of Applied Polymer Sci

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The adsorption of proteins onto polymeric surfaces is encountered in many natural and industrial processes and is a prerequisite to their efficient identification, separation, and purification by methods such as chromatography, and filtration. Nevertheless, the exact nature of the adsorption mechanisms and interfacial interactions is not easy to identify for a given protein-polymer system. Here, we aim to document the adsorption mechanism of a protein-polymer system by investigating the adsorption as well as desorption phenomenon of a protein [bovine serum albumin (BSA)] from the polymeric surface [polyethersulfone (PES)]. The analyses performed to document the adsorption mechanism of the BSA-PES system include scanning electron microscope (SEM), attenuated total reflection-Fourier transform infrared (FTIR), contact angle, zeta potential, surface charge density measurement, and Derjaguin-Landau-Verwey-Overbeek (DLVO). Here, SEM and FTIR identified the physical and chemical properties of pure PES and PES-BSA membranes. The low water contact angle of the PES-BSA membrane confirms its applicability for tissue engineering applications. Further, the zeta potential, surface charge density measurement, and DLVO analyses were performed to document the adsorption mechanism. The adsorption of BSA particles on the PES surface was carried out for pH values that ranged from 4 to 10 for contact times that ranged from 1 to 3 days. A monotonic increase in the zeta potential of the PES-BSA system indicated considerable adsorption of BSA particles on the PES surface. Further, BSA adsorption was very strong for pH values greater than 4.7 which confirms to strong electrostatic interactions between BSA and PES. The strong electrostatic interaction is also collaborated by low desorption rate, which was only 22% for pH 10 after 3 days of contact.

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Section: Introductionmentioning

confidence: 99%

Protein–polymer interaction: Transfer loading at interfacial region of PES‐based membrane and BSA

Sadegh

Sahay

Soni

2019

J of Applied Polymer Sci

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“…The appearance of new peaks at 1100-1500 cm −1 by Fourier transform-infrared spectroscopy (FT-IR) ( Supplementary Fig. 23) indicated the fracture of C = C bonds on the surface of the GO, further showing the successful modification of the surface 50,51 . Plainly, the water contact angle (WCA) decreased from 74.9°to 33.5°with the addition of SA and further decreased to 0°with the modification of the surface by GO (Fig.…”

Section: Resultsmentioning

confidence: 99%

Interfacial assembly of self-healing and mechanically stable hydrogels for degradation of organic dyes in water

et al. 2020

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Mussel-inspired hydrogels have gained attention for underwater applications, including treatment of wastewater. However, they are typically limited by poor mechanical properties, short-term mechanical stability and by not being reusable. Here, we develop a mechanically stable and self-healing hydrogel with high mechanical strength for the degradation of dyes in wastewater, based on cellulose-derived co-polydopamine@Pd nanoparticles. A dynamic catechol redox system was achieved by reversible conversion between semiquinone and quinone/hydroquinone radicals, endowing the hydrogel with stable mechanical properties and self-healing behavior. Furthermore, a graphene oxide membrane is covalently grafted on to the hydrogel surface, which regulates its water permeability and intercepts some metal ions or large particles, protecting the hydrogel structure. High catalytic activity for anionic and cationic dyes is achieved, with the degradation rate reaching more than 95% after multiple cycles without significant deterioration in performance or hydrogel structure. Our work demonstrates a route to achieve mechanically stable hydrogels for degradation of organic dyes in wastewater.

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“…[226] In particular, GO and reduced graphene oxide (rGO) (the form of, e.g., chemically or thermally reduced GO) are used in biomedical applications due to their hydrophilic character, which allows for better biocompatibility and binding of GO and rGO to drug molecules through -stacking and hydrophilic interactions, thus improving the drug loading capacity of hydrogels. [227] However, upon conversion of the planar sp 2 lattice of graphene into a sp 3 lattice, GO and rGO lose their electron mobility.…”

Section: Electroresponsive Injectable Hydrogels For Controlled and Lomentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

222

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

Cited by 114 publications

References 227 publications

Protein–polymer interaction: Transfer loading at interfacial region of PES‐based membrane and BSA

Protein–polymer interaction: Transfer loading at interfacial region of PES‐based membrane and BSA

Interfacial assembly of self-healing and mechanically stable hydrogels for degradation of organic dyes in water

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

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