Graphene oxide-based nanocomposites (GO-chitosan and GO-EDTA) for outstanding antimicrobial potential against some Candida species and pathogenic bacteria

Khalil, Waleed F.; El-Sayyad, Gharieb S.; Rouby, Waleed M. A. El; Sadek, M. A.; Farghali, Ahmed A.; El-Batal, Ahmed I.

doi:10.1016/j.ijbiomac.2020.07.205

Cited by 65 publications

(38 citation statements)

References 77 publications

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“…13,14 Previous studies have reported that RGO has antimicrobial activity, [15][16][17] and GO when conjugated with active ingredients exhibits antimicrobial and antinematodal activities. 18,19 Furthermore, metal and metal oxide nanoparticles, such as silver, [20][21][22] zinc oxide, [23][24][25] and nickel oxide, 26,27 are widely used as antimicrobials, and a silver boron nano-formulation is a potential nematicide. 28 Furthermore, RGO-based metal oxide nanocomposites have garnered much attention as antimicrobials in the last few years.…”

Section: Introductionmentioning

confidence: 99%

Promising antimicrobial and antibiofilm activities of reduced graphene oxide-metal oxide (RGO-NiO, RGO-AgO, and RGO-ZnO) nanocomposites

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Promising antimicrobial and antibiofilm activities of reduced graphene oxide-metal oxide (RGO-NiO, RGO-AgO, and RGO-ZnO) nanocomposites

et al. 2021

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“…The last result indicates the presence of carboxyl and amino groups supporting a new covalent functionalization between the carboxylic acid on the GO and the amino of CS [31]. Additionally, the band corresponding to the amide group confirms bond formation between CS and GO [39].…”

Section: Resultsmentioning

confidence: 87%

Synthesis and fabrication of films including graphene oxide functionalized with chitosan for regenerative medicine applications

Valencia

Llano

Zuluaga

et al. 2021

Heliyon

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Graphene oxide (GO) has recently gained attention as a scaffold reinforcing agent for tissue engineering. Biomechanical and biological properties through a synergistic effect can be strengthened when combined with other materials such as chitosan (CS). For that reason, chitosan was used for Graphene Oxide (GO) functionalization through an amide group whose formation was evident by bands around 1600 cm À1 in the FTIR analysis. Furthermore, bands located at 1348 cm À1 (D band), 1593 cm À1 (G band), and 2416 cm À1 (2D band) in the RAMAN spectrum, and the displacement of the signal at 87.03 ppm (C5) in solid-state 13 C-NMR confirmed the amide formation. Films including the CS-GO compound were prepared and characterized by thermogravimetric analysis (TGA), where CS-GO film presented a lighter mass loss (~10% less loosed) than CS due probably to the covalent functionalization with GO, providing film thermal resistance. The CS-GO films synthesized were implanted in Wistar rats' subdermal tissue as a first approximation to the biological response. In vivo tests showed a low inflammatory response, good cicatrization, and advanced resorption at 60 days of implantation, as indicated by histological images. It was evidenced that the covalent union between CS and GO increased biocompatibility and the degradation/resorption capacity, demonstrating tissue regeneration with typical characteristics and tiny remnants of implanted material surrounded by a type III collagen capsule. These results show the potential application of the new synthesized films, including the CS-GO compound, in tissue engineering.

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“…The silver component in Ag@MOF (Figure 2e,f) is well dispersed, mainly with a size of about 7 nm in diameter. Synthetic graphene oxide has a curved and folded structure, and there are some cracks (Figure 2g,h) [43]. The addition of GO (Ag@MOF-GO) resulted in the formation of longer, regular rods with a diameter almost twice that of the MOF itself (Figure 2i,j).…”

Section: Characterization Of Ag@mof-gomentioning

confidence: 99%

Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing

Zhang

Wang

et al. 2021

Polymers

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Due to the spread of drug-resistant bacteria in hospitals, the development of antibacterial dressings has become a strategy to control wound infections caused by bacteria. Here, we reported a green strategy for in situ biomimetic syntheses of silver nanoparticles@organic frameworks/graphene oxide (Ag@MOF–GO) in sericin/chitosan/polyvinyl alcohol hydrogel. Ag@MOF–GO was synthesized in situ from the redox properties of tyrosine residues in silk sericin without additional chemicals, similar to a biomineralization process. The sericin/chitosan/Ag@MOF–GO dressing possessed a high porosity, good water retention, and a swelling ratio. The hemolysis rate of the composite was 3.9% and the cell viability rate was 131.2%, which indicated the hydrogel possessed good biocompatibility. The composite also showed excellent lasting antibacterial properties against drug-sensitive and drug-resistant pathogenic bacteria. The composite possessed excellent hemostatic activity. The coagulation effect of the composite may be related to its effect on the red blood cells and platelets, but it has nothing to do with the activation of coagulation factors. An in vitro cell migration assay confirmed and an in vivo evaluation of mice indicated that the composite could accelerate wound healing and re-epithelialization. In summary, the composite material is an ideal dressing for accelerating hemostasis, preventing bacterial infection, and promoting wound healing.

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Graphene oxide-based nanocomposites (GO-chitosan and GO-EDTA) for outstanding antimicrobial potential against some Candida species and pathogenic bacteria

Cited by 65 publications

References 77 publications

Promising antimicrobial and antibiofilm activities of reduced graphene oxide-metal oxide (RGO-NiO, RGO-AgO, and RGO-ZnO) nanocomposites

Promising antimicrobial and antibiofilm activities of reduced graphene oxide-metal oxide (RGO-NiO, RGO-AgO, and RGO-ZnO) nanocomposites

Synthesis and fabrication of films including graphene oxide functionalized with chitosan for regenerative medicine applications

Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing

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