Graphene Oxide-Based Simple and Rapid Detection of Antibiotic Resistance Gene via Quantum Dot-Labeled Zinc Finger Proteins

Ha, Dat Thinh; Nguyen, Van-Thuan; Kim, Moon‐Soo

doi:10.1021/acs.analchem.1c00560

Cited by 21 publications

(33 citation statements)

References 44 publications

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“…To overcome antibiotic resistance, Kim et al [76] synthesized a ZFP-GO (G19) probe through the interconnection of zinc finger proteins (ZFPs) and 2D nanosheet GO. ZFPlabeled quantum dots (QD) were applied over the GO nanosheet, which quenched the fluorescence intensity via the FRET mechanism (Figure 21).…”

Section: Dna and Rna Sensormentioning

confidence: 99%

“…Schematic illustration of the ZFP-GO (G19) FRET system and its dsDNA sensing approach. Reprinted from [76] with permission from the American Chemical Society. Reprinted from [76] with permission from the American Chemical Society.…”

Section: Dna and Rna Sensormentioning

confidence: 99%

“…Reprinted from [76] with permission from the American Chemical Society. Reprinted from [76] with permission from the American Chemical Society. Xiao and He et al [77] fabricated GOQDs (G20) for the detection of DNA sequences (Figure 22).…”

Section: Dna and Rna Sensormentioning

confidence: 99%

“…Figure 21. Schematic illustration of the ZFP-GO (G19) FRET system and its dsDNA sensing approach.Reprinted from[76] with permission from the American Chemical Society.…”

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confidence: 99%

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Role of Förster Resonance Energy Transfer in Graphene-Based Nanomaterials for Sensing

et al. 2022

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Förster resonance energy transfer (FRET)-based fluorescence sensing of various target analytes has been of growing interest in the environmental, bioimaging, and diagnosis fields. Graphene-based zero- (0D) to two-dimensional (2D) nanomaterials, such as graphene quantum dots (GQDs), graphene oxide (GO), reduced graphene oxide (rGO), and graphdiyne (GD), can potentially be employed as donors/acceptors in FRET-based sensing approaches because of their unique electronic and photoluminescent properties. In this review, we discuss the basics of FRET, as well as the role of graphene-based nanomaterials (GQDs, GO, rGO, and GD) for sensing various analytes, including cations, amino acids, explosives, pesticides, biomolecules, bacteria, and viruses. In addition, the graphene-based nanomaterial sensing strategy could be applied in environmental sample analyses, and the reason for the lower detection ranges (micro- to pico-molar concentration) could also be explained in detail. Challenges and future directions for designing nanomaterials with a new sensing approach and better sensing performance will also be highlighted.

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Section: Dna and Rna Sensormentioning

confidence: 99%

Section: Dna and Rna Sensormentioning

confidence: 99%

Section: Dna and Rna Sensormentioning

confidence: 99%

“…Figure 21. Schematic illustration of the ZFP-GO (G19) FRET system and its dsDNA sensing approach.Reprinted from[76] with permission from the American Chemical Society.…”

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confidence: 99%

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Role of Förster Resonance Energy Transfer in Graphene-Based Nanomaterials for Sensing

et al. 2022

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“…Among the various analytical techniques reported for quantifying antibiotics including chromatography-based techniques, enzyme-linked immunosorbent assays, luminescence assays, surface-plasmon-resonance assays, fluorescent assays, and aptamer-based sensors, electrochemical methods are particularly suitable. ,, Specifically, having the advantages of high selectivity and sensitivity, rapid analysis, low cost, ease in use, and easy miniaturization, − electrochemical techniques can be used for high-fidelity antibiotic quantification.…”

Section: Introductionmentioning

confidence: 99%

Nitrogen-Doped Graphdiyne Quantum Dots for Electrochemical Chloramphenicol Quantification in Water

Wang

Qiao

et al. 2021

ACS Appl. Nano Mater.

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Nitrogen-doped graphdiyne quantum dots (NGDYQDs) have been synthesized hydrothermally from sphybridized N-doped graphdiyne and employed to fabricate an electrochemical sensor for the quantification of chloramphenicol (CAP), a typical nitro group-containing antibiotic, in water. The principle of this quantification is based on the high electrocatalytic activity of NGDYQDs to the reduction of −NO 2 groups in CAP to hydroxylamine groups. The effects of the electronic structure and size of the quantum dots on electrocatalytic activity were studied experimentally and theoretically. To prepare a sensor for CAP quantification, a suspension of NGDYQDs was prepared, and the NGDYQDs were deposited on a glassy carbon (GC) electrode. The prepared sensor showed a linear response to CAP from 0.1 to 114.5 μM with a limit of detection of approximately 5 nM (at a signal-to-noise ratio of 3) and a sensitivity of approximately 8.79 μA −1 μM −1 cm −2 , as well as high repeatability, reproducibility, and stability. Moreover, the sensor has high selectivity and resistance to interference in the presence of other antibiotics (five randomly selected antibiotics: furazolidone, 2-nitroimidazole, amoxicillin, ciprofloxacin, and erythromycin), common biological compounds (glucose, ascorbic acid, and uric acid), common aqueous ions

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Quantum Dots for Pathogenic Bacterial Monitoring and Combating

Liu

Zhang

2022

Advanced Optical Materials

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including neonatal meningitis, [6] diarrhoea, [7] infected cutaneous wound [8] or bloodstream diseases, [9][10][11] etc. Antibiotic treatment strategies against these bacteria have been widely applied while antimicrobial resistance has been arousing gradually. [12][13][14][15][16][17] What is worse, the biofilmrelated infection has been a tough issue for bacterial infectious treatment since it is usually chronic and much harder to eradicate. [18][19][20] Therefore, effective antibacterial treatments for drug-resistant pathogenic bacteria are vital problems for clinical therapy. [21] Some anti-microbial trials were carried out like phages, bacteriocins, and antimicrobial peptides [22] along with various therapeutic methods. [23][24][25] Among them, nanomaterials are considered as compatible solutions [23,26] due to their facile synthesis methods and rich-sourced precursors, broad-spectrum sterilization, and low drug resistance. [27][28][29][30][31] Nanomaterials are generally easy to be modified or doped to enhance the affinity toward bacteria for the sake of combating or drug delivery. [32][33][34][35] The antibacterial mechanism [36,37] could be result from the sharp edges-based physical cutting, [38,39] photothermal effects, [40][41][42] and photo dynamic or chemical dynamic properties, that could produce reactive oxygen species (ROS).Pathogenic bacteria monitoring mainly conducted by culturing them in agar-based media, and subsequently testing them with biochemical probes. [43][44][45][46] Although this conventional method enables clinical diagnoses with relatively reliable outcomes, the long culturing time renders the "golden therapeutical window" for patients. So more rapid and accurate detecting technologies have been invented. One of the most evolutionary methods is the polymerase chain reaction, [47][48][49] which can identify the bacterial classification and provide gene expression level in a few hours with better accuracy. [47,50] Besides, the coupling of chromatography and mass spectra like matrix-assisted laser desorption ionization time-of-flight mass spectrometry [51][52][53][54][55] can play a more exact role in diagnosis. [56] Though these advanced instrumental-relied methods can lead to fast diagnostic, the expensive apparatus, environmentally unfriendly reagents, [57] professional sites and technical personnel requirements limited their utilization in real-time monitoring and point-of-care sensing. By contrast, easy and fast monitoring methods for the pathogen, such as electrochemical and fluorescence sensors, were brought out as powerful supplements. [58][59][60][61][62] Therein, Antibiotic resistance and pathogenic bacterial monitoring are two main challenges in clinical diagnostics and treatment of bacteria. To conquer those issues, many new materials and novel technologies are explored. Among them, quantum dots (QDs) are regarded as not only powerful bacteriostatic agents, but also bacterial monitoring probes due to their excellent photoluminescence properties, tunable multiwavelength lumine...

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Graphene Oxide-Based Simple and Rapid Detection of Antibiotic Resistance Gene via Quantum Dot-Labeled Zinc Finger Proteins

Cited by 21 publications

References 44 publications

Role of Förster Resonance Energy Transfer in Graphene-Based Nanomaterials for Sensing

Role of Förster Resonance Energy Transfer in Graphene-Based Nanomaterials for Sensing

Nitrogen-Doped Graphdiyne Quantum Dots for Electrochemical Chloramphenicol Quantification in Water

Quantum Dots for Pathogenic Bacterial Monitoring and Combating

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