Graphene-Oxide-Coated CuO Nanoparticles for Functionalization of Acetylsalicylic Acid and Diclofenac

Abstract

A single-step ultrasonic method (20 kHz, 18 W/ cm 2 ) is demonstrated for the functionalization of pristine nonsteroidal anti-inflammatory drugs: acetylsalicylic acid and diclofenac with preformed graphene-oxide-coated CuO nanoparticles. These nanoparticles are positively charged and have a flower-like morphology with a mean size of <340 nm consisting of a pure CuO phase. Ultrasound causes complexation of each drug with these nanoparticles, and as a consequence, new advanced pharmaceutical nanocomposites, acetylsalicylic-acid−grapheneoxide-coated CuO and diclofenac−graphene-oxide-coated CuO, are formed. The surface composition and electronic molecular structure of these nanocomposites are modified at pH values from 1 to 8 through the specific interactions involving Cu−O, C−H, and H-bond formation with the carboxylic and carbonyl groups of acetylsalicylic acid, diclofenac, and graphene oxide.

Evolution of graphene oxide (GO)-based nanohybrid materials with diverse compositions: an overview

“…In a relatively different approach 116 GO-coated CuO nanoparticles have been exploited for functionalization with anti-inflammatory drugs viz. acetylsalicylic acid (ASA/aspirin) and diclofenac (DC) using the ultrasonic method (20 kHz, 18 W cm −2 ).…”

Potent E. coli M-17 Growth Inhibition by Ultrasonically Complexed Acetylsalicylic Acid–ZnO–Graphene Oxide Nanoparticles

“…Distinct from these studies, we have recently proposed a new concept based on the functionalization of pristine drugs through complexation with preformed metal−metal or metal−oxide−graphene nanoparticles by ultrasound. Instead of loading or encapsulation of drugs, we have demonstrated the functionalization of pristine NSAIDs such as ketorolac, ASA, and diclofenac through the sonochemical complexation with preformed Cu/Fe−GO, 32 Fe 3 O 4 −GO, 33 or CuO−GO 34 nanoparticles with improved pH-dependent hydrophilicity properties. Copper, copper/iron, and iron−graphene−ketorolac nanoparticles acquired higher surface-active area, which facilitated the drug disintegration at a slower rate from copper/iron−graphene−ketorolac at increased pH, but at a faster rate from iron−graphene−ketorolac nanoparticles starting from acidic conditions.…”

Effect of ultrasound on nonsteroidal anti-inflammatory drugs complexed with copper, iron, zinc and graphene oxides

“…В жидкости ультразвук приводит к возникновению акустической кавитации и, как следствие, сонохимии. Установлено, что сонохимия может успешно применяться в процессе синтеза графена и его модифировании с помощью медно-железных нанокомпозитов [8], наночастиц Fe3O4 [9] и CuO [10] посредством комплексообразования с кеторолаком, аспирином или диклофенаком в водной среде. В связи с этим в данной работе представлено, как с помощью ультразвука можно улучшить электромагнитные свойства кеторолака и ацетилсалициловой кислоты посредством их комплексообразования с наночастицами Cu/Fe-, ZnO-и Fe3O4 в водной фазе.…”