2016
DOI: 10.1002/adhm.201500824
|View full text |Cite|
|
Sign up to set email alerts
|

Graphene Oxide‐Copper Nanocomposite‐Coated Porous CaP Scaffold for Vascularized Bone Regeneration via Activation of Hif‐1α

Abstract: Graphene has been studied for its in vitro osteoinductive capacity. However, the in vivo bone repair effects of graphene-based scaffolds remain unknown. The aqueous soluble graphene oxide-copper nanocomposites (GO-Cu) are fabricated, which are used to coat porous calcium phosphate (CaP) scaffolds for vascularized bone regeneration. The GO-Cu nanocomposites, containing crystallized CuO/Cu2 O nanoparticles of ≈30 nm diameters, distribute uniformly on the surfaces of the porous scaffolds and maintain a long-term … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
117
0
3

Year Published

2017
2017
2024
2024

Publication Types

Select...
9

Relationship

3
6

Authors

Journals

citations
Cited by 153 publications
(124 citation statements)
references
References 48 publications
4
117
0
3
Order By: Relevance
“…49 This discovery is further confirmed in a study of graphene oxide–copper nanocomposite (GO-Cu) coated porous calcium phosphate (CaP) scaffolds. 56 The GO-Cu upregulated the expression of Hif-1 α and enhanced the secretion of VEGF and bone morphometric protein 2 (BMP-2) in MSCs by activating the extracellular signal-regulated kinases 1/2 (Erk1/2) signaling pathway. The GO-Cu coated CaP cement scaffolds significantly promoted angiogenesis and osteogenesis in a calvarial defect rat model.…”
Section: Discussionmentioning
confidence: 99%
“…49 This discovery is further confirmed in a study of graphene oxide–copper nanocomposite (GO-Cu) coated porous calcium phosphate (CaP) scaffolds. 56 The GO-Cu upregulated the expression of Hif-1 α and enhanced the secretion of VEGF and bone morphometric protein 2 (BMP-2) in MSCs by activating the extracellular signal-regulated kinases 1/2 (Erk1/2) signaling pathway. The GO-Cu coated CaP cement scaffolds significantly promoted angiogenesis and osteogenesis in a calvarial defect rat model.…”
Section: Discussionmentioning
confidence: 99%
“…[26] Cells were cultured in high-glucose Dulbecco's modified Eagle medium (DMEM) (HyClone, USA) supplemented with 10% fetal bovine serum (FBS, Gibco, USA), 100 U mL −1 streptomycin, and 100 U mL −1 penicillin at 37 °C in an atmosphere of 5% CO 2 . [26] Cells were cultured in high-glucose Dulbecco's modified Eagle medium (DMEM) (HyClone, USA) supplemented with 10% fetal bovine serum (FBS, Gibco, USA), 100 U mL −1 streptomycin, and 100 U mL −1 penicillin at 37 °C in an atmosphere of 5% CO 2 .…”
Section: Methodsmentioning
confidence: 99%
“…[26] Two full thickness defects with a 5 mm diameter were made on both sides of the rat skull, and spheroids from the following four groups were implanted: SA spheroids (SA), SA spheroids with 5 × 10 −3 m Mg 2+ (SA-Mg), cell-laden spheroids (SA-BMSCs), and cellladen spheroids with 5 × 10 −3 m Mg 2+ (SA-Mg/BMSCs). [26] Two full thickness defects with a 5 mm diameter were made on both sides of the rat skull, and spheroids from the following four groups were implanted: SA spheroids (SA), SA spheroids with 5 × 10 −3 m Mg 2+ (SA-Mg), cell-laden spheroids (SA-BMSCs), and cellladen spheroids with 5 × 10 −3 m Mg 2+ (SA-Mg/BMSCs).…”
Section: Methodsmentioning
confidence: 99%
“…Copper has been reported to stimulate bone regeneration by upregulating Erk and HIF‐1α . Moreover, in previous reports, the Akt, Erk, and p38 signal pathways have been shown to be involved in cells migration .…”
Section: Resultsmentioning
confidence: 92%