Graphene oxide decorated with Cu(<scp>i</scp>)Br nanoparticles: a reusable catalyst for the synthesis of potent bis(indolyl)methane based anti HIV drugs

Srivastava, Ananya; Agarwal, Aakanksha; Gupta, Seema; Jain, Nidhi

doi:10.1039/c6ra02458k

Cited by 17 publications

(6 citation statements)

References 31 publications

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“…For EAuNPs (black) multiple faint aberrations were observed, which is most likely due to the noise associated with EAuNPs. In the second spectrum, the two peaks were observed at 1353 cm −1 and 1593 cm −1 , which corresponds to the characteristic peaks of rGO (red; designated as D and G peaks, respectively) . In the next spectrum, when EAuNPs‐rGO nanocomposite was evaluated the appearance of similar peaks with the enhanced intensity was observed (blue).…”

Section: Resultsmentioning

confidence: 94%

Design and Development of Ultrafast Sinapic Acid Sensor Based on Electrochemically Nanotuned Gold Nanoparticles and Solvothermally Reduced Graphene Oxide

et al. 2019

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We report for the first time sinapic acid (SA) sensing based on nanocomposite comprising electrochemically tuned gold nanoparticles (EAuNPs) and solvothermally reduced graphene oxide (rGO). The synthesized EAuNPs, rGO, and EAuNPs‐rGO nanocomposite were characterized using X‐ray diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED), particle size analysis, and Raman spectroscopy. A proof‐of‐concept electrochemical sensor for SA was developed based on synthesized EAuNPs‐rGO nanocomposite, which was characterized by electrochemical techniques such as cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The developed sensor detected SA with a linear dynamic range (LDR) between 20 μM and 200 μM and detection limit (DL) of 33.43 (±0.21) nM (RSD<3.32 %). To show the useful purpose of the sensor probe in clinical applications, SA was detected in human urine samples, which showed the percentage recovery between 82.6 % and 92.8 %. Interferences due to various molecules such as L‐cystine, glycine, alanine, serum albumin, uric acid, citric acid, ascorbic acid, and urea were tested. Long‐term stability of the sensor probe was examined, which was found to be stable up to 6 weeks. The sensor fabricated using EAuNPs‐rGO nanocomposite has many attractive features such as; simplicity, rapidity, and label‐free detection; hence, it could be a method of choice for SA detection in various matrices.

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Section: Resultsmentioning

confidence: 94%

Design and Development of Ultrafast Sinapic Acid Sensor Based on Electrochemically Nanotuned Gold Nanoparticles and Solvothermally Reduced Graphene Oxide

et al. 2019

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“…The same year, Jain and her research team opted out of the use of silica as the support for their nanocompounds, instead picking graphene oxide (GO), due to its unique morphology and high chemical stability ( Scheme 20 ) [ 112 ]. The graphene oxide was decorated with CuBr nanoparticles, which had already shown great catalytic potential, forming the GO–CuBr complex that was utilized for the synthesis of BIMs.…”

Section: Reviewmentioning

confidence: 99%

“…Thus, a solvent-free approach was reported with the lowest amount of nanocatalyst applied, compared to previous methodologies. However, conventional heating was still needed and not all carbonyl compounds managed to form the respective BIMs in the present conditions [ 112 ].…”

Section: Reviewmentioning

confidence: 99%

Green and sustainable approaches for the Friedel–Crafts reaction between aldehydes and indoles

Kolagkis,

Galathri,

Kokotos

2024

Beilstein J. Org. Chem.

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The synthesis of indoles and their derivatives, more specifically bis(indolyl)methanes (BIMs), has been an area of great interest in organic chemistry, since these compounds exhibit a range of interesting biological and pharmacological properties. BIMs are naturally found in cruciferous vegetables and have been shown to be effective antifungal, antibacterial, anti-inflammatory, and even anticancer agents. Traditionally, the synthesis of BIMs has been achieved upon the acidic condensation of an aldehyde with indole, utilizing a variety of protic or Lewis acids. However, due to the increased environmental awareness of our society, the focus has shifted towards the development of greener synthetic technologies, like photocatalysis, organocatalysis, the use of nanocatalysts, microwave irradiation, ball milling, continuous flow, and many more. Thus, in this review, we summarize the medicinal properties of BIMs and the developed BIM synthetic protocols, utilizing the reaction between aldehydes with indoles, while focusing on the more environmentally friendly methods developed over the years.

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“…Graphene has excellent electrical conductivity and a very high specific surface area and mechanical strength [ 78 ], so it has become the main nanomaterial for constructing enzymatic biofuel cells. Liu et al [ 79 ] used graphene to construct a bioanode in an EBFC for the first time.…”

Section: The Application Of Nanomaterials In Enzyme Biofuel Cellsmentioning

confidence: 99%

Research Progress in Enzyme Biofuel Cells Modified Using Nanomaterials and Their Implementation as Self-Powered Sensors

Cao,

Chen,

Pang

et al. 2024

Molecules

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Enzyme biofuel cells (EBFCs) can convert chemical or biochemical energy in fuel into electrical energy, and therefore have received widespread attention. EBFCs have advantages that traditional fuel cells cannot match, such as a wide range of fuel sources, environmental friendliness, and mild reaction conditions. At present, research on EBFCs mainly focuses on two aspects: one is the use of nanomaterials with excellent properties to construct high-performance EBFCs, and the other is self-powered sensors based on EBFCs. This article reviews the applied nanomaterials based on the working principle of EBFCs, analyzes the design ideas of self-powered sensors based on enzyme biofuel cells, and looks forward to their future research directions and application prospects. This article also points out the key properties of nanomaterials in EBFCs, such as electronic conductivity, biocompatibility, and catalytic activity. And the research on EBFCs is classified according to different research goals, such as improving battery efficiency, expanding the fuel range, and achieving self-powered sensors.

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Graphene oxide decorated with Cu(i)Br nanoparticles: a reusable catalyst for the synthesis of potent bis(indolyl)methane based anti HIV drugs

Abstract: A reusable nanocatalytic system comprising Cu(i)Br decorated on graphene oxide has been prepared, and successfully applied for an efficient synthesis of bis(indolyl)methanes. The synthesized compound 3d shows significant anti-HIV-1 activity.

Cited by 17 publications

References 31 publications

Design and Development of Ultrafast Sinapic Acid Sensor Based on Electrochemically Nanotuned Gold Nanoparticles and Solvothermally Reduced Graphene Oxide

Design and Development of Ultrafast Sinapic Acid Sensor Based on Electrochemically Nanotuned Gold Nanoparticles and Solvothermally Reduced Graphene Oxide

Green and sustainable approaches for the Friedel–Crafts reaction between aldehydes and indoles

Research Progress in Enzyme Biofuel Cells Modified Using Nanomaterials and Their Implementation as Self-Powered Sensors

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