Graphene oxide-doping improves the biocompatibility and separation performance of polyethersulfone hollow fiber membranes for bioartificial kidney application

Hollow fibre membrane bioreactor functionalized with GO‐cryogel 3D matrix promotes liver cell anchoring and their functional maintenance

“…Haemolysis refers to the lysis of RBCs when the human blood comes in contact with a membrane material. Therefore, it is desirable to have haemolysis value within the permissible haemolytic limit, which is 5% as prescribed by the ASTM F‐756‐08 standard (Modi et al, 2018c; Verma, Modi, Singh, Teotia, & Bellare, 2018). In this study, the developed materials showed the haemolysis value <5%, that is, within the prescribed limit, which indicated that these HFMs are suitable for blood‐contacting applications (Figure 9a) (Padalhin et al, 2014).…”

“…Haemolysis refers to the lysis of RBCs when the human blood comes in contact with a membrane material. Therefore, it is desirable to have haemolysis value within the permissible haemolytic limit, which is 5% as prescribed by the ASTM F-756-08 standard (Modi et al, 2018c;. In this study, the developed materials showed the F I G U R E 7 EDS elemental analysis showed additional Na and N spectra in the PTC-CrG HFMs, which confirmed the surface modification of HFMs by cryogel coating F I G U R E 8 (a) ATR-FTIR spectra and (b) hydrophilicity of different HFM samples haemolysis value <5%, that is, within the prescribed limit, which indicated that these HFMs are suitable for blood-contacting applications (Figure 9a) (Padalhin et al, 2014).…”

“…It is one of the promising biomaterials as it offers additional beneficial properties such as its biological origin, biodegradability and biocompatibility (Malafaya et al, 2007). The use of GO, in recent times, as a promising biocompatible material, has drawn the attention of the research community, especially tissue engineers (Modi et al, 2018c). Moreover, it may be noted that functionalized multi‐walled carbon nanotubes (CNTs) as fillers in polymer membranes to improve the biocompatibility and separation performance has also gained the attention as discussed in the literature (Abidin et al, 2017; Kaleekkal et al, 2016; Saliev, 2019; Tan et al, 2014).…”

A Review of Commercial Developments and Recent Laboratory Research of Dialyzers and Membranes for Hemodialysis Application

“…The hemolytic rate of the membrane modified by silver nanoparticles (3.04%), however, was lower than that of the membrane modified by MWCNT-Arg (3.28%), revealing that silver nanoparticles have a lower toxicity compared to MWCNT-Arg. Modi et al [107] introduced 2D graphene oxide (GO) nanosheets into PES hollow fiber membranes and obtained better membrane properties in terms of hydrophilicity, hemocompatibility, cell attachment and separation performance. This is due to the remarkable interfacial compatibility between GO and PES.…”

Lactobionic acid-functionalized polyethersulfone hollow fiber membranes promote HepG2 attachment and function

“…5). Several literature studies showed that the improved hydrophilicity either by blending hydrophilic additive to the native PES 16,21,22,29 or chemically modifying the membrane 23,30,31 resulted in enhanced cell adhesion. The positive effect of improving hydrophilicity on cell attachment and proliferation was observed in this study, which is discussed later in the manuscript.…”