Graphene oxide-enhanced sol-gel transition sensitivity and drug release performance of an amphiphilic copolymer-based nanocomposite

Abstract

We report the fabrication of a highly sensitive amphiphilic copolymer-based nanocomposite incorporating with graphene oxide (GO), which exhibited a low-intensity UV light-triggered sol-gel transition. Non-cytotoxicity was observed for the composite gels after the GO incorporation. Of particular interest were the microchannels that were formed spontaneously within the GO-incorporated UV-gel, which expedited sustained drug release. Therefore, the present highly UV-sensitive, non-cytotoxic amphiphilic copolymer-based composites is expected to provide enhanced photothermal therapy and chemotherapy by means of GO’s unique photothermal properties, as well as through efficient passive targeting resulting from the sol-gel transition characteristic of the copolymer-based system with improved sensitivity, which thus promises the enhanced treatment of patients with cancer and other diseases.

Biodegradable Polylactide/TiO2 Composite Fiber Scaffolds with Superhydrophobic and Superadhesive Porous Surfaces for Water Immobilization, Antibacterial Performance, and Deodorization

“…Conversely, the average number of the viable bacteria cells on the standard control test specimen in the absence of the ES PLA/TiO 2 fibers was dramatically increased after the 24 h of visible light irradiation, likely because bacterial proliferation readily proceeded without the inhibition effect from the destructive reactive oxygen species generated by the photocatalytic reactions over the PLA/TiO 2 fibers. As a result, the as-prepared PLA/TiO 2 fibers can find promising antimicrobial applications by considering its high antibacterial efficiency, as well as its robust and portable merits that cannot be obtained in the traditional powdery samples [34,35,36,37,38,39,40,41,42,43,44,45,46]. R 1 = (( N 0 – N 24h )/ N 0 ) × 100…”

Functionalization of Molecularly Imprinted Polymer Microspheres for the Highly Selective Removal of Contaminants from Aqueous Solutions and the Analysis of Food-Grade Fish Samples

“…Increasing worldwide concern regarding environmental pollution has inspired researchers to explore high-performance functional materials to remediate the contaminated global environment, especially aquatic systems that have a key impact on human life and food supply [1,2,3,4,5,6,7,8,9,10,11,12]. Various kinds of functional materials have thus been reported for achieving environmental remediation [3,4,13,14,15,16,17,18,19,20,21].…”

Combining Pickering Emulsion Polymerization with Molecular Imprinting to Prepare Polymer Microspheres for Selective Solid-Phase Extraction of Malachite Green

“…These reported molecularly imprinted materials are commonly used for sustained drug release applications. To our knowledge, using Pickering emulsion polymerization as the method and MG as the template for preparation of polymer microspheres (used for detection and selective purification of MG) has not been reported so far, and the use of such polymer microspheres for solid phase extraction applications has also not been found through the literature review [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ].…”