Graphene oxide fiber microelectrodes with controlled sheet alignment for sensitive neurotransmitter detection

Jarosova, Romana; Ostertag, Blaise J.; Ross, Ashley E.

doi:10.1039/d3nr02879h

Cited by 5 publications

(20 citation statements)

References 55 publications

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“…Similarly, the purines guanosine and adenosine (Figure S7B,C) show primary oxidation current improvements of 2.3 ± 0.3 and 1.2 ± 0.1-fold, respectively, illustrating the unique surface interactions of similar neurochemical structures vastly differing in their detection enhancements. Adenosine has been shown to interact more poorly at edge plane-enhanced electrodes, indicating that WCG-derived porous carbon modifications could hinder adenosine detection improvements . Additional neurochemical structures, ascorbic acid, serotonin, and histamine (Figure S7D–F), exhibited slowed electron transfer rates with increases in oxidation current of 2.4 ± 0.4, 1.9 ± 0.2, and 1.4 ± 0.1-fold, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Adenosine has been shown to interact more poorly at edge plane-enhanced electrodes, indicating that WCG-derived porous carbon modifications could hinder adenosine detection improvements. 48 Additional neurochemical structures, ascorbic acid, serotonin, and histamine (Figure S7D−F), exhibited slowed electron transfer rates with increases in oxidation current of 2.4 ± 0.4, 1.9 ± 0.2, and 1.4 ± 0.1-fold, respectively. Overall, WCG-modified CFMEs present a viable electrode material for enhanced FSCV detection utility for numerous other neurochemicals with slightly sluggish electron transfer kinetics.…”

Section: ■ Experimental Methodsmentioning

confidence: 99%

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Waste Coffee Ground-Derived Porous Carbon for Neurochemical Detection

Ostertag,

Syeed,

Brooke

et al. 2024

ACS Sens.

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We present an optimized synthetic method for repurposing coffee waste to create controllable, uniform porous carbon frameworks for biosensor applications to enhance neurotransmitter detection with fast-scan cyclic voltammetry. Harnessing porous carbon structures from biowastes is a common practice for low-cost energy storage applications; however, repurposing biowastes for biosensing applications has not been explored. Waste coffee ground-derived porous carbon was synthesized by chemical activation to form multivoid, hierarchical porous carbon, and this synthesis was specifically optimized for porous uniformity and electrochemical detection. These materials, when modified on carbon-fiber microelectrodes, exhibited high surface roughness and pore distribution, which contributed to significant improvements in electrochemical reversibility and oxidative current for dopamine (3.5 ± 0.4-fold) and other neurochemicals. Capacitive current increases were small, showing evidence of small increases in electroactive surface area. Local trapping of dopamine within the pores led to improved electrochemical reversibility and frequencyindependent behavior. Overall, we demonstrate an optimized biowaste-derived porous carbon synthesis for neurotransmitter detection for the first time and show material utility for viable neurotransmitter detection within a tissue matrix. This work supports the notion that controlled surface nanogeometries play a key role in electrochemical detection.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Experimental Methodsmentioning

confidence: 99%

Waste Coffee Ground-Derived Porous Carbon for Neurochemical Detection

Ostertag,

Syeed,

Brooke

et al. 2024

ACS Sens.

Self Cite

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“…This local trapping generates temporally resolved measurements similar to CNTs and GO fibers. 26 , 27 , 44 , 45 Traditional CF is synthesized by a process called wetspinning, a process using an organic carbon-rich polymer that is carbonized and annealed to form an amorphous CF framework. Our lab has made recent developments to introduce secondary polymers that decompose during the heating process rendering macroporous geometries capable of improving measurement temporal resolution (not to the extent of CNTs or CNPEs) through porous geometries altering the surface chemical connectivity of these porous CFs (Fig.…”

Section: Unobserved Events Caused By Diminished Temporal Resolutionmentioning

confidence: 99%

“…Our lab recently developed a method to control the alignment of the edge-plane of GO sheets to promote carefully controlled experiments of neurochemical interactions at the surface. 45 Preliminary studies show GO sheet alignment plays a vital role in purine detection depleting adenosine interfacial interactions while enhancing that of guanosine at edge plane-aligned GO microfibers. 44 , 45 These results support the need for fine-tuned microfibers to investigate and understand electrode-neurochemical interfacial interactions at a molecular level.…”

Section: Lacking Controllability In Surface Chemistry Tunabilitymentioning

confidence: 99%

“… 45 Preliminary studies show GO sheet alignment plays a vital role in purine detection depleting adenosine interfacial interactions while enhancing that of guanosine at edge plane-aligned GO microfibers. 44 , 45 These results support the need for fine-tuned microfibers to investigate and understand electrode-neurochemical interfacial interactions at a molecular level. Unfortunately, graphene microfibers exhibit depleted mechanical properties, so more work is needed for implantation applications and universal neurochemical usage.…”

Section: Lacking Controllability In Surface Chemistry Tunabilitymentioning

confidence: 99%

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Editors’ Choice—Review—The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective

Ostertag,

Ross

2023

ECS Sens. Plus

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Carbon-based sensors have remained critical materials for electrochemical detection of neurochemicals, rooted in their inherent biocompatibility and broad potential window. Real-time monitoring using fast-scan cyclic voltammetry has resulted in the rise of minimally invasive carbon fiber microelectrodes as the material of choice for making measurements in tissue, but challenges with carbon fiber’s innate properties have limited its applicability to understudied neurochemicals. Here, we provide a critical review of the state of carbon-based real-time neurochemical detection and offer insight into ways we envision addressing these limitations in the future. This piece focuses on three main hinderances of traditional carbon fiber based materials: diminished temporal resolution due to geometric properties and adsorption/desorption properties of the material, poor selectivity/specificity to most neurochemicals, and the inability to tune amorphous carbon surfaces for specific interfacial interactions. Routes to addressing these challenges could lie in methods like computational modeling of single-molecule interfacial interactions, expansion to tunable carbon-based materials, and novel approaches to synthesizing these materials. We hope this critical piece does justice to describing the novel carbon-based materials that have preceded this work, and we hope this review provides useful solutions to innovate carbon-based material development in the future for individualized neurochemical structures.

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Submersible voltammetric sensing probe for rapid and extended remote monitoring of opioids in community water systems

Zhou,

Ding,

Sandhu

et al. 2024

Microchim Acta

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The intensifying global opioid crisis, majorly attributed to fentanyl (FT) and its analogs, has necessitated the development of rapid and ultrasensitive remote/on-site FT sensing modalities. However, current approaches for tracking FT exposure through wastewater-based epidemiology (WBE) are unadaptable, time-consuming, and require trained professionals. Toward developing an extended in situ wastewater opioid monitoring system, we have developed a screen-printed electrochemical FT sensor and integrated it with a customized submersible remote sensing probe. The sensor composition and design have been optimized to address the challenges for extended in situ FT monitoring. Specifically, ZIF-8 metal–organic framework (MOF)-derived mesoporous carbon (MPC) nanoparticles (NPs) are incorporated in the screen-printed carbon electrode (SPCE) transducer to improve FT accumulation and its electrocatalytic oxidation. A rapid (10 s) and sensitive square wave voltammetric (SWV) FT detection down to 9.9 µgL−1 is thus achieved in aqueous buffer solution. A protective mixed-matrix membrane (MMM) has been optimized as the anti-fouling sensor coating to mitigate electrode passivation by FT oxidation products and enable long-term, intermittent FT monitoring. The unique MMM, comprising an insulating polyvinyl chloride (PVC) matrix and carboxyl-functionalized multi-walled carbon nanotubes (CNT-COOH) as semiconductive fillers, yielded highly stable FT sensor operation (> 95% normalized response) up to 10 h in domestic wastewater, and up to 4 h in untreated river water. This sensing platform enables wireless data acquisition on a smartphone via Bluetooth. Such effective remote operation of submersible opioid sensing probes could enable stricter surveillance of community water systems toward timely alerts, countermeasures, and legal enforcement. Graphical abstract

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Graphene oxide fiber microelectrodes with controlled sheet alignment for sensitive neurotransmitter detection

Abstract: Here, we synthesized and characterized graphene oxide (GO) fiber microelectrodes with controllable nanosheet orientation to study the extent to which sheet alignment and orientation impacts electrochemical detection of neurochemicals. The...

Cited by 5 publications

References 55 publications

Waste Coffee Ground-Derived Porous Carbon for Neurochemical Detection

Waste Coffee Ground-Derived Porous Carbon for Neurochemical Detection

Editors’ Choice—Review—The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective

Submersible voltammetric sensing probe for rapid and extended remote monitoring of opioids in community water systems

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