Graphene oxide modulates inter-particle interactions in 3D printable soft nanocomposite hydrogels restoring magnetic hyperthermia responses

Aluri, Esther Rani; Gannon, Edward; Singh, Krutika; Kolagatla, Srikanth; Kowiorski, Krystian; Shingte, Sameer D.; McKiernan, Eoin; Moloney, Cara; McGarry, Katie; Jowett, Liam; Rodriguez, Brian J.; Brougham, Dermot F.; Wychowaniec, Jacek K.

doi:10.1016/j.jcis.2021.12.048

Cited by 10 publications

(6 citation statements)

References 44 publications

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“…The combination of these errors provides an estimate of the error in SAR of ~5.0%. 41 The heat capacities used in calculating SAR were 1.483 J g -1 o C -1 for toluene and 4.186 J g -1 o C -1 for water. The heat capacity of toluene was used for calculating SAR of organogels.…”

Section: Synthesis Optimisationmentioning

confidence: 99%

Modulation of hyperthermic and relaxometric responses of magnetic iron oxide nanoparticles through ligand exchange provides design criteria for dual-functionality

et al. 2023

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Section: Synthesis Optimisationmentioning

confidence: 99%

Modulation of hyperthermic and relaxometric responses of magnetic iron oxide nanoparticles through ligand exchange provides design criteria for dual-functionality

et al. 2023

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“…Magnetic NPs have been explored for various clinical applications, including hyperthermia treatment, magnetic resonance imaging (MRI), biomarker detection, and magneticguided surgery. [155][156][157] These particles have been engineered using diverse materials, such as transition metals (Fe, Ni, Co), metal oxides (Fe 2 O 3 ), metal alloys (Fe─Ni, Fe─Pt, Fe─Co, Co─Pt), and rare metals (Gd, Eu) to enhance their application performance and improve physiological outcomes. [158,159] By applying a static external magnetic field, these NPs can be precisely guided and concentrated at the tumor site, enhancing drug delivery to cancer cells while minimizing exposure to healthy tissues.…”

Section: Magnetic-responsive Nanomaterialsmentioning

confidence: 99%

Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management

Elsherbeny,

Bayraktutan,

et al. 2023

Advanced Therapeutics

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Pancreatic cancer is characterized by a high mortality rate and unfavorable prognosis. This is primarily attributed to poor accumulation of therapeutic agents at the target site due to the presence of a highly complex tumor microenvironment surrounding the pancreatic cancer tissue. However, a promising avenue for targeted drug delivery has emerged in the form of stimuli‐responsive materials. These advanced nanocarriers, encompassing both external and internal stimuli‐responsive nanoparticles, can be formulated to control the release of therapeutic agents precisely in response to specific activation. By harnessing external stimuli such as light, ultrasound, or magnetic fields, as well as intrinsic biological triggers including pH, redox potential, hypoxia, and temperature, these nanomaterials exhibit ‘intelligent’ and selective responses within complex biological environments. These responsive nanoparticles have been shown to address challenges associated with poor vascularity and thick desmoplastic stromal layers, which are hallmarks of pancreatic cancer, by promoting enhanced drug accumulation and release at the target site relative to conventional therapy. This work explores the design strategies for advanced stimuli‐responsive nanomaterials, integrating both internal and external stimuli, with the potential to enhance drug delivery efficacy in pancreatic cancer. It addresses the challenges and prospects in their development and offers insights for future clinical applications.

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“…The graphene oxide (GO) production protocol is well described in the literature and is referred as Hummer’s method, alongside its multiple modifications [ 46 , 47 ]. In brief, GO synthesis is based on mixing graphite materials with strong oxidizers, such as fuming nitric acid or potassium chlorate.…”

Section: Physical and Chemical Properties Of Flake Graphene-based And...mentioning

confidence: 99%

Flake Graphene-Based Nanomaterial Approach for Triggering a Ferroptosis as an Attractive Theranostic Outlook for Tackling Non-Small Lung Cancer: A Mini Review

2022

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Lung cancer is a highly aggressive neoplasm that is now a leading cause of cancer death worldwide. One of the major approaches for killing cancer cells is related with activation of apoptotic cell death with anti-cancer drugs. However, the efficiency of apoptosis induction in tumors is limited. Consequently, the development of other forms of non-apoptotic cell death is up to date challenge for scientists worldwide. This situation motivated us to define the aim of this mini-review: gathering knowledge regarding ferroptosis—newly defined programmed cell death process characterized by the excessive accumulation of iron—and combining it with yet another interesting nanomaterial-based graphene approach. In this manuscript, we presented brief information about non-small lung cancer and ferroptosis, followed by a section depicting the key-features of graphene-based nanomaterials influencing their biologically relevant properties.

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Graphene oxide modulates inter-particle interactions in 3D printable soft nanocomposite hydrogels restoring magnetic hyperthermia responses

Cited by 10 publications

References 44 publications

Modulation of hyperthermic and relaxometric responses of magnetic iron oxide nanoparticles through ligand exchange provides design criteria for dual-functionality

Modulation of hyperthermic and relaxometric responses of magnetic iron oxide nanoparticles through ligand exchange provides design criteria for dual-functionality

Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management

Flake Graphene-Based Nanomaterial Approach for Triggering a Ferroptosis as an Attractive Theranostic Outlook for Tackling Non-Small Lung Cancer: A Mini Review

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