Graphene oxide reinforced hemostasis of gelatin sponge in noncompressible hemorrhage via synergistic effects

Wenjing, A; Du, Fanglin; He, Youwei; Wu, Bingxin; Liu, Fang; Liu, Yichun; Zheng, Weitao; Li, Guofeng; Wang, Xing

doi:10.1016/j.colsurfb.2022.112891

Cited by 8 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wenjing et al conducted an in vivo study to examine the effectiveness of a gelatin/graphene oxide sponge. By performing complete femoral incisions on 250 g SD rats, they observed a significant reduction of 76% in blood loss and a 45% decrease in coagulation time compared to the self-bleeding blank control …”

Section: Resultsmentioning

confidence: 99%

Development of Polyphosphate/Nanokaolin-Modified Alginate Sponge by Gas-Foaming and Plasma Glow Discharge Methods for Ultrarapid Hemostasis in Noncompressible Bleeding

Salmanipour,

Rezaie,

Alipour

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Effective bleeding management strategies in uncontrollable and noncompressible massive hemorrhage are becoming important in both clinical and combat situations. Here, a novel approach was developed to create a superporous and highly absorbable hemostatic sponge through a facile chemical gasfoaming method by cross-linking long-chain polyphosphate along with nanokaolin and Ca 2+ in an alginate structure to synergistically activate the coagulation pathway. Natural kaolin obtained from the Marand mine in East Azarbaijan was converted into pseudohexagonal-shaped kaolin nanoparticles (30 to 150 nm) using ball milling followed by a newly developed glow discharge plasma treatment method. The obtained ultralight sponges (>90% porosity) exhibit ultrarapid water/blood absorption capacity (∼4000%) and excellent shape memory, which effectively concentrates coagulation factors. The results of in vitro tests demonstrated that the proposed sponges exhibited enhanced blood clotting ability (BCI < 10%) and superior cohesion with red blood cells (∼100) and platelets (∼80%) compared to commercially available hemostatic products. The in vivo host response results exhibited biosafety with no systemic and significant local inflammatory response by hematological, pathological, and biochemical parameter assessments. In a rat femoral artery complete excision model, the application of alginate/k/polyp nanocomposite sponges resulted in a complete hemostasis time of 60 s by significant reduction of hemostasis time (∼6.7−8.3 fold) and blood loss (∼2−2.8-fold) compared to commercially available hemostatic agents (P < 0.001). In conclusion, distinct physical characteristics accompanied by unique chemical composition multifunctional sponges activate hemostasis synergistically by triggering the XII, XI, X, IX, V, and II factors and the contact pathway and have the ability of rapid hemostasis in noncompressible severe bleeding.

show abstract

Section: Resultsmentioning

confidence: 99%

Development of Polyphosphate/Nanokaolin-Modified Alginate Sponge by Gas-Foaming and Plasma Glow Discharge Methods for Ultrarapid Hemostasis in Noncompressible Bleeding

Salmanipour,

Rezaie,

Alipour

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Moreover, Wenjing et al developed gelatin (GP) and graphene oxide (GO) accounted for 0,1,5,10, and 20 wt% of the total solid mass, and composite sponge (GP-GO) was created donated as GP, GP-GO 1 , GP-GO 5 , GP-GO 10 , and GP-GO 20 . These samples exhibited stable cross-linked and outstanding absorbability [ 108 ]. The haemostatic impact of the GP-GO sponge with 5% GO was tested using two distinct rat models, including the puncture of the femoral artery and the puncture of the liver.…”

Section: Interaction Between Sponge and Haemostasis: Underlying Mecha...mentioning

confidence: 99%

“…In rat liver puncture model, it stopped bleeding in 36.0 ± 5.3 s. These findings demonstrated GP-GO potential for the treatment of noncompressible wound haemorrhage. The incorporation of GO improved the structure of the sponge and altered its degree of wettability [ 108 ].…”

Section: Interaction Between Sponge and Haemostasis: Underlying Mecha...mentioning

confidence: 99%

Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis

Nepal

Tran

Nguyen

et al. 2023

Bioactive Materials

View full text Add to dashboard Cite

The effect of mesoporous bioglass on hemostatic, antibacterial and biocompatible properties of composite sponge

Wang,

Zou,

et al. 2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Hemostatic materials used in penetrating injuries or incompressible wounds must possess exceptional efficacy in preventing bleeding. In this study, mesoporous bioglass (MBG) was synthesized using a two‐step acid‐catalyzed self‐assembly method, and a novel hemostatic sponge (MBG/CH/GEL) was prepared by combining chitosan (CH), gelatin (GEL), and MBG using a freeze‐drying method. The characteristics and hemostatic effects of the MBG/CH/GEL composite hemostatic sponge were analyzed and evaluated. Research has shown that the high specific surface area of MBG (730 m2/g) provides more blood cell adhesion sites during hemostasis, resulting in a low hemolysis rate, favorable swelling rate, and porosity of the hemostatic sponge. Additionally, MBG can release Si4+ and Ca2+ ions during hemostasis, giving the composite hemostatic sponge excellent cell compatibility and promoting cell growth. Compared with commercially available gelatin hemostatic sponges, it cannot only quickly stop bleeding but also has a greater compressive strength (212.07 kPa) and adhesion strength (11.54 ± 0.16 kPa), making it suitable for use in hemostasis of incompressible wounds. Furthermore, the composite hemostatic sponge exhibited significant antibacterial effects against Staphylococcus aureus and Escherichia coli. These results indicate that the MBG/CH/GEL composite hemostatic sponge, which is a hemostatic material, has promising applications.

show abstract

Graphene oxide reinforced hemostasis of gelatin sponge in noncompressible hemorrhage via synergistic effects

Cited by 8 publications

References 50 publications

Development of Polyphosphate/Nanokaolin-Modified Alginate Sponge by Gas-Foaming and Plasma Glow Discharge Methods for Ultrarapid Hemostasis in Noncompressible Bleeding

Development of Polyphosphate/Nanokaolin-Modified Alginate Sponge by Gas-Foaming and Plasma Glow Discharge Methods for Ultrarapid Hemostasis in Noncompressible Bleeding

Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis

The effect of mesoporous bioglass on hemostatic, antibacterial and biocompatible properties of composite sponge

Contact Info

Product

Resources

About