Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application

Mianehrow, Hanieh; Moghadam, M.H. Mohamadzadeh; Sharif, Farhad; Mazinani, Saeedeh

doi:10.1016/j.ijpharm.2015.02.069

Cited by 49 publications

(27 citation statements)

References 39 publications

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“…Release behaviour of FA from rGO-CS-HEC nanohybrid in PBS solution with pH of 5.3, (which has the same acidity as cancer cells (Du et al, 2011)), is presented in Fig.7a. As it is mentioned in our previous work (Mianehrow et al, 2015), FA release from the GO-HEC nanohybrid is quite low, which is due the low affinity of FA to acidic media and the strong interaction between FA and HEC. In addition, it was observed that by increasing the HEC amount in the nanohybrid, the FA release become significantly less (nearly 3% release after 72h for GO-HEC (1:25)), which shows the dominating role of HEC on release behaviour.…”

Section: Drug Loading and Release Behaviourmentioning

confidence: 66%

“…GO was synthesized from natural graphite via preoxidation/thermal expansion of graphite followed by modified Hummer's method (Hummers Jr and Offeman, 1958;McAllister et al, 2007), following the same procedure as our previous work (Mianehrow et al, 2015). At first step, 10 g of natural graphite flake were mixed with 3:1 volume ratio of H2SO4:HNO3 for 24 h at room temperature.…”

Section: Synthesis Of Gomentioning

confidence: 99%

“…It was first mixed with CS powder following by 15 minutes sonication, and then mixed with HEC powder by another 15 minutes sonication to produce a crystal clear solution of GO:CS:HEC with optimized mass ratio of 1:3:3. It is necessary to mention that we were aware that at least 1:6 mass ratio of rGO to HEC is required to get a stable suspension of rGO-HEC nanohybrid based on our previous work (Mianehrow et al, 2015) . Therefore, here we kept the ratio of rGO-polymer constant and changed the CS/HEC ratio.…”

Section: Preparation Of Rgo-cs-hec Rgo-cs and Rgo-hec Nanohybridsmentioning

confidence: 99%

“…In our previous study (Mianehrow et al, 2015), hydroxyethyl cellulose (HEC), a water soluble, non-ionic derivative of cellulose, was utilized as GO stabilizer for drug delivery application and the resultant nanohybrid presented high and long term stability in different electrolyte media, independent of the ionic nature of the solution. However, there was a conflict between stabilizing effect of HEC and its drug release capability.…”

Section: Introductionmentioning

confidence: 99%

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Introducing a highly dispersed reduced graphene oxide nano-biohybrid employing chitosan/hydroxyethyl cellulose for controlled drug delivery

Mianehrow

Afshari

Mazinani

et al. 2016

International Journal of Pharmaceutics

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In this research, an attempt was made to stabilize reduced graphene oxide (rGO) in all pH ranges, incorporating both chitosan (CS) and hydroxyethyl cellulose (HEC) to make a proper drug carrier with suitable stability and drug release behaviour. The stability of rGO-CS-HEC nanohybrid was assessed using field emission scanning electron microscopy (FE-SEM), ultraviolet-visible spectroscopy (UV-Vis) and Zeta potential measurements. Results depicted that the novel synthesized nanohybrid was stable in all pH ranges, due to the utilization of HEC, while without incorporation of this material, the rGO-CS nanohybrid aggregated at neutral and alkaline media, due to the ionic nature of chitosan. In addition, drug loading and release behaviour of folic acid (FA), as a model drug, was investigated to assess the role of chitosan on the release behaviour of FA from the rGO-CS-HEC nanohybrid in comparison with rGO-HEC and rGO-CS nanohybrids. It was proved that the resultant nanohybrid could release nearly 27% more FA than the rGO-HEC nanohybrid and only 9% lower than the rGO-CS nanohybrid during 120h. Moreover, the biocompatibility of the resultant nanohybrid was also checked to introduce the novel rGO-CS-HEC nanohybrid as a suitable candidate for drug delivery application.

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Section: Drug Loading and Release Behaviourmentioning

confidence: 66%

Section: Synthesis Of Gomentioning

confidence: 99%

Section: Preparation Of Rgo-cs-hec Rgo-cs and Rgo-hec Nanohybridsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Introducing a highly dispersed reduced graphene oxide nano-biohybrid employing chitosan/hydroxyethyl cellulose for controlled drug delivery

Mianehrow

Afshari

Mazinani

et al. 2016

International Journal of Pharmaceutics

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“…Graphene has a wide range of potential applications including electronic and optical devices, batteries, catalyst supports, composite materials and biomedical engineering. Drug delivery systems based on graphene and modified graphene have also attracted attention [46][47][48][49]. Aromatic drugs can be loaded onto the surfaces of carbon nanomaterials such as carbon nanotubes and graphene materials because of their noncovalent interaction including π-π stacking and hydrophobic interactions.…”

Section: Release Profiles Of S-drgo and S-dgchi Filmsmentioning

confidence: 99%

Preparation of a stable aqueous suspension of reduced graphene oxide by a green method for applications in biomaterials

Song

Han

et al. 2017

Journal of Colloid and Interface Science

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A green approach for the preparation of a stable reduced graphene oxide (RGO) suspension from graphene oxide (GO) has been developed. This method uses l-serine (l-Ser) as the reductant and yellow dextrin (YD) as the stabilizing agent. X-ray photoelectron spectroscopy, UV-vis spectroscopy, X-ray diffraction and thermogravimetric analyses showed that l-Ser can efficiently reduce GO at a comparatively low temperature, and that the YD adsorbed onto the RGO facilitating the formation of a stable RGO aqueous suspension. Since l-Ser and YD are natural environmentally friendly materials, this approach provides a green method to produce stable RGO from GO on a large scale. Sodium salicylate (SS) which has an aromatic structure was loaded onto the RGO through π-π interactions and a maximum loading capacity of 44.6mg/g was obtained. The release of the loaded SS can be controlled by adjusting the solution pH, and a 74.8% release was reached after 70h at pH 7.4. The release profile of SS could be further controlled by incorporating it into RGO Dispersed carboxylated chitosan films.

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Covalent and Non‐covalent Modification of Graphene Oxide Through Polymer Grafting

Hassanpour

Ghorbanpour

Tehrani

2016

Advanced 2D Materials

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Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application

Cited by 49 publications

References 39 publications

Introducing a highly dispersed reduced graphene oxide nano-biohybrid employing chitosan/hydroxyethyl cellulose for controlled drug delivery

Introducing a highly dispersed reduced graphene oxide nano-biohybrid employing chitosan/hydroxyethyl cellulose for controlled drug delivery

Preparation of a stable aqueous suspension of reduced graphene oxide by a green method for applications in biomaterials

Covalent and Non‐covalent Modification of Graphene Oxide Through Polymer Grafting

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