Graphene oxide toxicity in W1118 flies

Guo, Qing; Yang, Ying; Zhao, Lin; Chen, Jian; Duan, Guangxin; Yang, Zaixing; Zhou, Ruhong

doi:10.1016/j.scitotenv.2021.150302

Cited by 25 publications

(20 citation statements)

References 60 publications

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“…The D. melanogaster strain w 1118 flies exposed to GO at the concentrations of 10 -1000 μg/ml displayed developmental delay, reduction of adult eclosion in flies and decreased lifespan [24]. Used Another study demonstrated that 1 -10 μg/ml of GO exposure led to remarkable weight loss, delayed development, retarded motion, and shortened lifespan of w 1118 flies [13]. Exposure to carbon nanofibers at a concentration of 1000 μg/ml reduced larval viability, adult fly lifespan, reproductive activity, climbing activity, and starvation resistance in Canton-S flies [26].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of biological effects of graphene oxide using Drosophila

Strilbytska

Semaniuk

Burdyliuk

et al. 2022

Phys. Chem. Solid St.

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Graphene and its derivatives have attracted great interest because of their intriguing physical and chemical properties. An increasing phase of commercial production causes the presence of graphene in the environment and might pose a great threat to a wide range of living organisms, including bacteria, viruses, plants, invertebrates and mammals, including humans. In the present study, the graphene oxide (GO) at low doses was evaluated for its biological effects on larvae and the imago of Drosophila melanogaster. Oral administration of GO at concentrations of 0.02-1% has a beneficial effect on the developmental rate and hatching ability of larvae. Long-term administration of a low dose of GO extends Drosophila lifespan and significantly enhances resistance to environmental stresses. We also found that GO exposure led to a remarkable decrease in the level of hemolymph glucose, glycogen and triglycerides storage. These suggest about GO affects carbohydrate and lipid metabolism in adult Drosophila. These findings might provide a useful reference to assess the biological effects of GO, which could play an important role in a variety of graphene-based biomedical applications.

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Section: Discussionmentioning

confidence: 99%

“…It was recently shown significant behavioral and developmental disorders in Oregon-R flies after GO exposure at a very high concentration (50 -300 μg/mL) [12]. Another experimental study demonstrated that GO exposure exerted remarkable toxicities in w 1118 flies [13].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biological effects of graphene oxide using Drosophila

Strilbytska

Semaniuk

Burdyliuk

et al. 2022

Phys. Chem. Solid St.

View full text Add to dashboard Cite

show abstract

“…That being said, there are several authors who report the harmful effects that GO can have in several models; namely, Fu et al [ 115 ] reports the damaging effects to mice offspring in the lactation period; Chen et al [ 116 ] and Dasmahapatra et al [ 117 ] reported the toxicity GO poses to fish, especially when it is “released” into the environment, either during embryogenesis or adulthood; and Guo et al [ 118 ] reported these effects in W1118 flies.…”

Section: Graphene Oxide: Biocompatible or Cytotoxic?mentioning

confidence: 99%

Graphene Oxide Thin Films with Drug Delivery Function

et al. 2022

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Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.

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“…However, graphene and GO NSs themselves have been reported with toxicity toward living organisms based on various underlying mechanisms of toxicity, such as the inhibition of neuron development, damage to the reproductive system, and impairment of the nutrient absorption system. 186–189 Currently, little is known about the potential risk of graphene-based adsorbents to the environment. More studies should thus be conducted on this aspect before real-life practical applications.…”

Section: Summary and Perspectivesmentioning

confidence: 99%