Graphene quantum dots: A review on the effect of synthesis parameters and theranostic applications

Kansara, Vrushti; Tiwari, Sanjay; Patel, Manthan

doi:10.1016/j.colsurfb.2022.112605

Cited by 17 publications

(4 citation statements)

References 190 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This phenomenon is attributed to the surface electron transitions among the trap‐state energy levels (a semiconductor traps a carrier until it recombines), which mainly make heat through Shockley–Read–Hall electron–hole recombination or different defect‐associated paths (Belkahla et al, 2019). Thus, CDs have been considered excellent candidates for photothermal‐bactericidal usage (Kansara et al, 2022; P. Zhu et al, 2022). Nevertheless, it is essential to highlight that under NIR irradiation, the CDs do not present the best ability of photoconversion.…”

Section: Cds For Bacteria Eliminationmentioning

confidence: 99%

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Lagos

García

Cuadrado

et al. 2023

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Carbon dots (CDs) correspond to carbon‐based materials (CBM) with sizes usually below 10 nm. These nanomaterials exhibit attractive properties such us low toxicity, good stability, and high conductivity, which have promoted their thorough study over the past two decades. The current review describes four types of CDs: carbon quantum dots (CQDs), graphene quantum dots (GQDs), carbon nanodots (CNDs), and carbonized polymers dots (CPDs), together with the state of the art of the main routes for their preparation, either by “top‐down” or “bottom‐up” approaches. Moreover, among the various usages of CDs within biomedicine, we have focused on their application as a novel class of broad‐spectrum antibacterial agents, concretely, owing their photoactivation capability that triggers an enhanced antibacterial property. Our work presents the recent advances in this field addressing CDs, their composites and hybrids, applied as photosensitizers (PS), and photothermal agents (PA) within antibacterial strategies such as photodynamic therapy (PDT), photothermal therapy (PTT), and synchronic PDT/PTT. Furthermore, we discuss the prospects for the possible future development of large‐scale preparation of CDs, and the potential for these nanomaterials to be employed in applications to combat other pathogens harmful to human health. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease

show abstract

Section: Cds For Bacteria Eliminationmentioning

confidence: 99%

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Lagos

García

Cuadrado

et al. 2023

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…Benefiting from the superior physical and chemical properties (e.g., low toxicity, good hydrophilicity, and inherent stable strong fluorescence), quantum dots have been developed as potential drug candidates for the treatment of human diseases including cancers, diabetes, and NDs. 25,26 Importantly, a recent study demonstrates that graphene quantum dots (GQDs) can penetrate the blood−brain barrier, prevent pathological α-syn aggregation, and inhibit the loss of dopamine neurons and behavioral defects in a mouse model of Parkinson's disease. 27 This work highlights the potential application of GQDs in modulating protein aggregation for treatment of NDs.…”

mentioning

confidence: 99%

Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent Abnormal Phase Transition of Fused in Sarcoma Protein

Zhou

Zhang

et al. 2023

ACS Nano

View full text Add to dashboard Cite

Protein liquid−liquid phase separation (LLPS) plays a crucial role in mediating dynamic assembly of different membraneless organelles such as stress granules (SGs). Dysregulation of dynamic protein LLPS leads to aberrant phase transition and amyloid aggregation which is closely associated with neurodegenerative diseases. In this study, we found that three types of graphene quantum dots (GQDs) exhibit potent activity in preventing SG formation and promoting SG disassembly. We next demonstrate that GQDs can directly interact with the SGs-containing protein fused in sarcoma (FUS), inhibit and reverse FUS LLPS, and prevent its abnormal phase transition. Moreover, GQDs display superior activity in preventing amyloid aggregation of FUS and disaggregating preformed FUS fibrils. Mechanistic study further demonstrates that GQDs with different edge-site exhibit distinct binding affinity to FUS monomers and fibrils, which accounts for their distinct activities in modulating FUS LLPS and fibrillation. Our work reveals the potent capability of GQDs in modulating SG assembly, protein LLPS, and fibrillation and sheds light on rational design of GQDs as effective modulators of protein LLPS for therapeutics application.

show abstract

“…The interesting features of this group of materials make them appropriate tools for different applications from bioimaging and biosensing to drug delivery, tissue engineering, antimicrobial and antiviral applications, photodynamic/photothermal therapy, and regenerative medicine. [100][101][102][103][104] The presence of different groups on the surface of graphene-based materials provides the ability to functionalize graphene with different molecules that make them appropriate for targeted delivery as well as reducing the probable toxicity effect. In addition, the wide surface of these compounds provides a huge place for loading therapeutic compounds via different reactions (including π-π stacking, hydrophobic interactions, or hydrogen bonding).…”

Section: Graphene/derivatives In Neurosciencementioning

confidence: 99%

Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

Zarepour,

Karasu,

Mir

et al. 2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Graphene quantum dots: A review on the effect of synthesis parameters and theranostic applications

Cited by 17 publications

References 190 publications

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Carbon dots: Types, preparation, and their boosted antibacterial activity by photoactivation. Current status and future perspectives

Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent Abnormal Phase Transition of Fused in Sarcoma Protein

Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

Contact Info

Product

Resources

About