2024
DOI: 10.1016/j.inoche.2024.112032
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Graphene quantum dots: Background, synthesis methods, and applications as nanocarrier in drug delivery and cancer treatment: An updated review

Mohammad Hossein Karami,
Majid Abdouss,
Abbas Rahdar
et al.
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Cited by 27 publications
(2 citation statements)
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“…The formation of a large number of irregular neovascularization in tumor tissues leads to impaired lymphatic drainage, and macromolecular compounds are highly permeable to tumor tissues and can be retained in tumor tissues, that is, enhanced permeability and retention (EPR) effect. Studies have shown that EPR effect can induce the accumulation of not only macromolecular compounds but also many nanomaterials, especially those with particle size between 10 and 400 nm. In this context, the method of loading chemotherapy drugs with nanomaterials of appropriate size and delivering them to the tumor sites not only helps to exert the efficacy of chemotherapy drugs but also reduces the toxic and side effects of chemotherapy drugs to a certain extent, showing good development prospects. However, relevant studies also face the following problems: (1) the loading rate of chemotherapy drugs is generally low; (2) it is difficult to achieve controlled release of chemotherapy drugs at the tumor sites; and (3) most of the carriers themselves have no therapeutic function, and the effect of single chemotherapy is very limited.…”
Section: Introductionmentioning
confidence: 99%
“…The formation of a large number of irregular neovascularization in tumor tissues leads to impaired lymphatic drainage, and macromolecular compounds are highly permeable to tumor tissues and can be retained in tumor tissues, that is, enhanced permeability and retention (EPR) effect. Studies have shown that EPR effect can induce the accumulation of not only macromolecular compounds but also many nanomaterials, especially those with particle size between 10 and 400 nm. In this context, the method of loading chemotherapy drugs with nanomaterials of appropriate size and delivering them to the tumor sites not only helps to exert the efficacy of chemotherapy drugs but also reduces the toxic and side effects of chemotherapy drugs to a certain extent, showing good development prospects. However, relevant studies also face the following problems: (1) the loading rate of chemotherapy drugs is generally low; (2) it is difficult to achieve controlled release of chemotherapy drugs at the tumor sites; and (3) most of the carriers themselves have no therapeutic function, and the effect of single chemotherapy is very limited.…”
Section: Introductionmentioning
confidence: 99%
“…The charged functional groups of the modifier molecules act as repulsive agents towards other CeO 2 NPs, creating a stable colloid.The creation of multifunctional particles has great potential for biomedical applications. [22][23][24][25] As a rule, the existing approaches to synthesizing and modifying CeO 2 NPs are complex and multi-stage. Furthermore, the use of additional steps to functionalize the CeO 2 NP surface significantly increases the cost of the resulting product.…”
mentioning
confidence: 99%