Grasa epicárdica en la población general de mediana edad y su asociación con el síndrome metabólico

Calabuig, Álvaro; Barba, Joaquín; Guembe, María Jesús; Dı́ez, Javier; Berjón, Jesús; Martínez‐Vila, E.; Irimia, P.; Toledo, Estefanía

doi:10.1016/j.recesp.2016.07.025

Cited by 17 publications

(3 citation statements)

References 37 publications

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“…To our knowledge, the present study is the first to evaluate the role of t2DM on the relation between EAT and longitudinal strain. In this regard, higher values of EAT in subjects with t2DM had previously been reported [10,15,16]; while we further observed that most of the subjects with EAT > 4.2 mm and concomitant t2DM showed a limited deformation capacity of the cardiac myofibril (Table 1).…”

Section: Discussionsupporting

confidence: 80%

Epicardial adipose tissue thickness is related to early subclinical myocardial dysfunction, particularly in patients with type 2 diabetes mellitus: a case control study

Prestegui-Muñóz

Benítez-Maldonado

Rodríguez-Álvarez

et al. 2022

BMC Cardiovasc Disord

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Background Cardiac myofibrillary dysfunction, which can be measure by echocardiographical strain value, represents an early subclinical manifestation of heart failure. Epicardial Adipose tissue (EAT) is related to low degree inflammation and oxidative damage in the adjacent tissue. Aim To explore whether EAT affects early myocardial dysfunction, as assessed strain values. Methods Case–Control design. Patients lacking clinical significant heart failure, thyroid or renal disease or malignant abnormalities were included. Clinical-demographic and biochemical data were collected. EAT and myofibril deformation were measured by echocardiography. Results A total of 71 patients were analyzed, and further subdivided according to type 2 Diabetes Mellitus (t2DM). Higher strain value (higher than -22.4%cut-off value) was associated with male sex and higher anthropometric and metabolic risk measures; particularly those with t2DM. Higher EAT was also associated higher strain value (AUC = 0.92 ± 0.06, p = 0.004), and further correlation was evidenced (rho = 0.488, p < 0.001), with significant influence of t2DM. Conclusion EAT was related to strain value, suggesting the influence of cardiac adipose tissue on the deformability of cardiac myofibril, with a more significant effect in the population with t2DM.

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Section: Discussionsupporting

confidence: 80%

Epicardial adipose tissue thickness is related to early subclinical myocardial dysfunction, particularly in patients with type 2 diabetes mellitus: a case control study

Prestegui-Muñóz

Benítez-Maldonado

Rodríguez-Álvarez

et al. 2022

BMC Cardiovasc Disord

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“…One of the most interesting findings was the significant association between increased EAT and the prevalence of metabolic syndrome and each of its components even after adjusting for possible confounders. (12,(14)(15)(16) The estimation of EAT could provide more accurate information than that obtained with other variables used for the quantification of adipose tissue, such as waist circumference or body mass index, since these parameters do not differentiate between visceral and subcutaneous adipose tissue.…”

Section: Epicardial Adipose Tissue and Atherosclerosismentioning

confidence: 99%

Epicardial Adipose Tissue as Predictor of Coronary Artery Disease. A New Parameter to Stratify Cardiovascular Risk?

Creta¹,

Higa²,

Masson³

2022

Rev Argent Cardiol

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The association between visceral adipose tissue and cardiovascular disease has been clearly established. Likewise, it has been determined that ectopic adiposity is associated with a higher cardiovascular risk compared to subcutaneous adiposity. In this context, multiple investigations have evaluated the role of epicardial adipose tissue (EAT) in cardiovascular disease. EAT is located between the myocardial surface and the visceral layer of the pericardium, and can be quantified by noninvasive techniques such as echocardiography, computed tomography, or magnetic resonance imaging. The EAT is not simply a storage organ. Currently, it is considered to be a metabolically active tissue capable of secreting multiple adipokines that act through different paracrine, endocrine, vasocrine and/or autocrine signaling pathways. Current evidence suggests that EAT may be a contributing factor in the pathogenesis of coronary heart disease, as well as being associated with its severity and progression. In this sense, some authors have postulated EAT as a new cardiovascular risk factor and as a potential therapeutic target. The aim of this review is to analyze the association between EAT and cardiovascular disease, mainly coronary artery disease.

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“…Composition, structure, and function of adipose tissue are highly dependent on individual metabolic factors that we are still learning. Ectopic AT covering different organs may have different anatomic and functional characteristics and due to its proximity to various internal organs may exert organ-specific regulatory functions [13].…”

Section: Introductionmentioning

confidence: 99%

Stem cells from human cardiac adipose tissue depots show different gene expression and functional capacities

et al. 2019

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BackgroundThe composition and function of the adipose tissue covering the heart are poorly known. In this study, we have investigated the epicardial adipose tissue (EAT) covering the cardiac ventricular muscle and the EAT covering the left anterior descending artery (LAD) on the human heart, to identify their resident stem cell functional activity.MethodsEAT covering the cardiac ventricular muscle was isolated from the apex (avoiding areas irrigated by major vessels) of the heart (ventricular myocardium adipose tissue (VMAT)) and from the area covering the epicardial arterial sulcus of the LAD (PVAT) in human hearts excised during heart transplant surgery. Adipose stem cells (ASCs) from both adipose tissue depots were immediately isolated and phenotypically characterized by flow cytometry. The different behavior of these ASCs and their released secretome microvesicles (MVs) were investigated by molecular and cellular analysis.ResultsASCs from both VMAT (mASCs) and the PVAT (pASCs) were characterized by the expression of CD105, CD44, CD29, CD90, and CD73. The angiogenic-related genes VEGFA, COL18A1, and TF, as well as the miRNA126-3p and miRNA145-5p, were analyzed in both ASC types. Both ASCs were functionally able to form tube-like structures in three-dimensional basement membrane substrates. Interestingly, pASCs showed a higher level of expression of VEGFA and reduced level of COL18A1 than mASCs. Furthermore, MVs released by mASCs significantly induced human microvascular endothelial cell migration.ConclusionOur study indicates for the first time that the resident ASCs in human epicardial adipose tissue display a depot-specific angiogenic function. Additionally, we have demonstrated that resident stem cells are able to regulate microvascular endothelial cell function by the release of MVs.

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Grasa epicárdica en la población general de mediana edad y su asociación con el síndrome metabólico

Cited by 17 publications

References 37 publications

Epicardial adipose tissue thickness is related to early subclinical myocardial dysfunction, particularly in patients with type 2 diabetes mellitus: a case control study

Epicardial adipose tissue thickness is related to early subclinical myocardial dysfunction, particularly in patients with type 2 diabetes mellitus: a case control study

Epicardial Adipose Tissue as Predictor of Coronary Artery Disease. A New Parameter to Stratify Cardiovascular Risk?

Stem cells from human cardiac adipose tissue depots show different gene expression and functional capacities

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