Gratitude is often considered a sub-sector of positive psychology. The aim of this study was to examine whether health status and self-esteem could predict gratitude scores in a sample of women. A non-clinical female sample (N = 200) completed self-reported measures online. A hierarchical multiple regression analysis was used to examine whether health status and self-esteem could significantly predict gratitude scores. Findings revealed that health status did not significantly predict gratitude scores in the sample of women in the current study. However, self-esteem was found to statistically predict gratitude scores, suggesting that women with low self-esteem levels were more likely to have lower gratitude scores, which is supported by previous research. The implications of this finding may benefit treatment programs, to increase self-esteem levels in individuals to achieve higher gratitude levels, resulting in various benefits for overall health and well-being.