The workers and researchers in the field of gravity exploration methods, always dream that it is possible one day, to be able to separate completely the Bouguer gravity anomalies and trace rock’ formations, and their densities distribution from a prior known control points (borehole) to any extended distance in the direction of the profile lines-it seems that day become will soon a tangible true! and it becomes possible for gravity interpretation methods to mimic to some extent the 2D seismic interpretation methods. Where, the present chapter is dealing a newly 2D semi-inversion, fast, and easily applicable gravitational technique, based on Bouguer gravity anomaly data. It now becomes possible through, Excel software, Matlab’s code, and a simple algorithm; separating the Bouguer anomaly into its corresponding rock’ formations causative sources, as well as, estimating and tracing its thicknesses (or depths) of sedimentary formations relative to the underlying basement’s structure rocks for any sedimentary basin, through using of profile(s) line(s) and previously known control points. The newly proposed method has been assessed, examine, and applied for two field cases, Abu Roash Dome Area, southwest Cairo, Egypt, and Humble Salt Dome, USA. The method has demonstrated to some extent comparable results with prior known information, for drilled boreholes.