Gray and white matter volumes in schizophrenia and bipolar disorder

Zipursky, Robert B.; Bury, Alison; Langevin, Ronald; Seeman, Mary V.

doi:10.1016/0006-3223(94)91033-2

Cited by 9 publications

(10 citation statements)

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“…In schizophrenia, the most consistent structural neuro-imaging findings are larger lateral and third ventricles and smaller gray matter volumes (Gur et al 2000a;Gur et al 2000b;Harvey et al 1993;Lim et al 1996;Zipursky et al 1998;Zipursky et al 1992;Zipursky et al 1997). White matter volumes in patients with schizophrenia tend not to be different from controls (Lim et al 1996;Zipursky et al 1998;Zipursky et al 1992).…”

Section: Introductionmentioning

confidence: 92%

Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome

Chow

Zipursky

Mikulis

et al. 2002

Biological Psychiatry

101

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Background-22q11 Deletion Syndrome is a genetic syndrome associated with an increased risk for developing schizophrenia. Brain abnormalities have been reported in 22q11 Deletion Syndrome, but little is known about whether differences in brain structure underlie the psychotic disorders associated with this syndrome. In the current study, we used magnetic resonance imaging to characterize the structural brain abnormalities found in adults who have both 22q11 Deletion Syndrome and schizophrenia.

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Section: Introductionmentioning

confidence: 92%

Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome

Chow

Zipursky

Mikulis

et al. 2002

Biological Psychiatry

101

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“…More specifically, asymmetry reversal was reported for posterior STG in patients diagnosed as having schizophrenia but not in patients diagnosed as having bipolar disorder. 24 Zipursky et al 48 similarly found global volume reduction in gray matter in first-episode psychotic patients but not in first-episode affective psychotic patients. Harvey et al 49 also reported a decrease in cortical volume in patients with schizophrenia but not in patients with bipolar disorder.…”

Section: Musiek and Reevesmentioning

confidence: 97%

Planum Temporale and Heschl Gyrus Volume Reduction in Schizophrenia: A Magnetic Resonance Imaging Study of First-Episode Patients

Hirayasu

McCarley

Salisbury

et al. 2000

Archives of General Psychiatry

247

168

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Background-Magnetic resonance imaging studies in schizophrenia have revealed abnormalities in temporal lobe structures, including the superior temporal gyrus. More specifically, abnormalities have been reported in the posterior superior temporal gyrus, which includes the Heschl gyrus and planum temporale, the latter being an important substrate for language. However, the specificity of the Heschl gyrus and planum temporale structural abnormalities to schizophrenia vs affective psychosis, and the possible confounding roles of chronic morbidity and neuroleptic treatment, remain unclear.

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“…17 Few studies have directly compared cortical volume in adults with schizophrenia to that in adults with other active psychosis. [18][19][20][21][22][23][24][25] These studies have not yielded consistent results, although differences in the brain regions studied and in the specific diagnostic subtypes of the psychotic (nonschizophrenic) groups may have contributed to disparate findings.…”

Section: Introductionmentioning

confidence: 93%

Brain volumes in psychotic youth with schizophrenia and mood disorders

Elsayed

Steen

Poe

et al. 2010

jpn

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229Background: We sought to test the hypothesis that deficits in grey matter volume are characteristic of psychotic youth with early-onset schizophrenia-spectrum disorders (EOSS) but not of psychotic youth with early-onset mood disorders (EOMD). Methods: We used magnetic resonance imaging to examine brain volume in 24 psychotic youth (13 male, 11 female) with EOSS (n = 12) or EOMD (n = 12) and 17 healthy controls (10 male, 7 female). We measured the volume of grey and white matter using an automated segmentation program. Results: After adjustment for age and intracranial volume, whole brain volume was lower in the EOSS patients than in the healthy controls (p = 0.001) and EOMD patients (p = 0.002). The EOSS patients had a deficit in grey matter volume (p = 0.005), especially in the frontal (p = 0.003) and parietal (p = 0.006) lobes, with no significant differences in white matter volume. Limitations: The main limitations of our study were its small sample size and the inclusion of patients with depression and mania in the affective group. Conclusion: Adolescents with EOSS have grey matter deficits compared with healthy controls and psychotic adolescents with EOMD. Our results suggest that grey matter deficits are not generally associated with psychosis but may be specifically associated with schizophrenia. Larger studies with consistent methods are needed to reconcile the contradictory findings among imaging studies involving psychotic youth.

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Gray and white matter volumes in schizophrenia and bipolar disorder

Cited by 9 publications

References 0 publications

Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome

Structural brain abnormalities in patients with schizophrenia and 22q11 deletion syndrome

Planum Temporale and Heschl Gyrus Volume Reduction in Schizophrenia: A Magnetic Resonance Imaging Study of First-Episode Patients

Brain volumes in psychotic youth with schizophrenia and mood disorders

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