Gray Hair in Black Males A Possible Risk Factor in Coronary Artery Disease

Eisenstein, Isaac; Edelstein, Josef

doi:10.1177/000331978203301004

Cited by 13 publications

(10 citation statements)

References 5 publications

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“…One of the earliest clinical signs which may possibly help in recognizing early onset of CAD in a young smoker is the presence of premature graying of hair. Although this sign was described as early as in 80's by Eisentein et al (5,6) and later few studies from our centre have also shown similar results (7,8), it has become a subject of intense research only very recently in the western world (9).…”

Section: Introductionsupporting

confidence: 70%

Premature graying of hair: An independent risk marker for coronary artery disease in smokers - A retrospective case control study

Aggarwal¹,

Srivastava²,

Mb³

et al. 2015

Ethiop J Health Sci

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BACKGROUND: Premature graying of hair as a risk marker among young smokers has a potential of identifying coronary artery disease (CAD) at a very early stage. There is absence of literature that assesses premature graying of hair as an independent marker of CAD in smokers. MATERIAL AND METHODS: The present single-centre case control study enrolled a total of 62 consecutive chronic smokers (≤ 45 years) (Group I) and 60 consecutive young CAD patients (≤45 years) who were chronic smokers (Group II). Another group comprising of 114 patients (≤45 years) having no smoking history and no cardiac ailments either (Group III) was enrolled as control population. All subjects were males. A detailed history and clinical examination regarding conventional coronary risk factors and carotid intima media thickness was done in both groups. RESULTS: The carotid intima media thickness, dyslipidemia and blood pressure were significantly higher in group I and II as compared to group III. When the groups were compared for graying of hair, it was found that the group II (i.e., smokers and CAD) had maximum prevalence of graying which was significantly higher than the control as well as smoker groups. The presence of premature graying of hair was associated with 3.24 times the risk of CAD on multiple logistic regression analysis. CONCLUSION: The presence of premature graying of hair was associated with an increased risk of CAD in young smokers. Premature graying of hair can be used as preliminary evidence by clinicians for classifying patients at risk for premature CAD especially in smokers.

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Section: Introductionsupporting

confidence: 70%

Premature graying of hair: An independent risk marker for coronary artery disease in smokers - A retrospective case control study

Aggarwal¹,

Srivastava²,

Mb³

et al. 2015

Ethiop J Health Sci

View full text Add to dashboard Cite

show abstract

“…One of the earliest clinical signs which may possibly help in recognizing early onset of CAD in a young smoker is the presence of premature graying of hair. Although this sign was described as early as in 80's by Eisentein et al ( 5 , 6 ) and later few studies from our centre have also shown similar results ( 7 , 8 ), it has become a subject of intense research only very recently in the western world ( 9 ).…”

Section: Introductionsupporting

confidence: 70%

Premature graying of hair: An independent risk marker for coronary artery disease in smokers - A retrospective case control study

Aggarwal

Srivastava

et al. 2014

Indian Heart Journal

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BackgroundPremature graying of hair as a risk marker among young smokers has a potential of identifying coronary artery disease (CAD) at a very early stage. There is absence of literature that assesses premature graying of hair as an independent marker of CAD in smokers.Material and MethodsThe present single-centre case control study enrolled a total of 62 consecutive chronic smokers (≤ 45 years) (Group I) and 60 consecutive young CAD patients (≤45 years) who were chronic smokers (Group II). Another group comprising of 114 patients (≤45 years) having no smoking history and no cardiac ailments either (Group III) was enrolled as control population. All subjects were males. A detailed history and clinical examination regarding conventional coronary risk factors and carotid intima media thickness was done in both groups.ResultsThe carotid intima media thickness, dyslipidemia and blood pressure were significantly higher in group I and II as compared to group III. When the groups were compared for graying of hair, it was found that the group II (i.e., smokers and CAD) had maximum prevalence of graying which was significantly higher than the control as well as smoker groups. The presence of premature graying of hair was associated with 3.24 times the risk of CAD on multiple logistic regression analysis.ConclusionThe presence of premature graying of hair was associated with an increased risk of CAD in young smokers. Premature graying of hair can be used as preliminary evidence by clinicians for classifying patients at risk for premature CAD especially in smokers.

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“…Our findings also supported these observations and detailed them. Afterwards, subsequent studies with various sample sizes were performed in different patient populations including CAD, myocardial infarction in black or white men or women (5)(6)(7)(8)(9)(10)(11). Several of these reports also showed association between premature hair whitening and myocardial infarction, although many are relatively outdated and have some methodological limitations, especially in determining the extent of CAD and intensity of hair whitening.…”

Section: Discussionmentioning

confidence: 99%

The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age

Kocaman

Çetin²,

Durakoğlugil³

et al. 2012

Anadolu Kardiyol Derg

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The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological ageKoroner arter hastalığı için bağımsız bir risk öngörücüsü olarak saçın erken beyazlama düzeyi: Zamansal yaştan çok biyolojik yaşın öngörücüsü ABSTRACTObjective: Age is the most important and uncorrectable coronary risk factor at the moment. The concept of measuring aging biologically rather than only chronologically may be of importance in clinical practice. Hair graying is the most apparent sign of biological aging in humans, yet its mechanism is largely unknown. Today, it is known that cardiovascular risk factors (CVRFs), especially in combination, cause premature atherosclerosis. In our opinion, premature hair graying or whitening may represent early atherosclerotic changes as a surrogate of host response to the CVRFs. In this study, we planned to investigate the relationship of hair graying with CVRFs and coronary atherosclerotic burden in order to determine whether it is an independent marker for coronary artery disease (CAD). Methods: The current study has a cross-sectional observational design. Two hundred and thirteen men who underwent coronary angiography with a suspicion of CAD were enrolled in the study. The patients were evaluated in terms of age, demographical properties and the CVRFs. Hair whitening score (HWS) was defined according to extent of gray/white hairs (1: pure black; 2: black>white; 3: black=white; 4: white>black; 5: pure white). Coronary atherosclerotic burden was assessed by the Gensini score. Analyses were performed in age-matched normal coronary arteries (NCA) and CAD groups. Linear and logistic regression analyses were used for the multivariate analyses of independent variables associated with hair greying. Results: The CVRFs were higher in CAD group. Hair whitening score (2.7±1.3 vs. 3.3±1.2, p=0.002), hair losing score (1.2±0.9 vs. 1.5±1.0, p=0.038) and xanthelasma rate (24% vs. 45%, p=0.013) were also significantly different between NCA and CAD groups. Age (p<0001), Gensini score (p<0.001) and coronary severity score (p=0.001) were higher in the categories of increased HWS. In multiple logistic regression analysis, only diabetes mellitus (OR: 3.240, 95% CI: [1.017-10.319], p=0.047), low-density lipoprotein cholesterol, (OR: 1.014, 95%CI: [1.001-1.027], p=0.029) and HWS (OR: 1.513, 95% CI: [1.054-2.173], p=0.025) were independently related to presence of CAD. Age (p<0.001), family history of CAD (p=0.004), hyperlipidemia (p=0.02) and serum creatinine levels (p=0.019) were found as independent predictors of hair graying. Conclusion: In our study, we found that the degree of gray/white hairs is related to extent of CAD. Our findings also suggested that hair graying is a risk marker for CAD independent of age and other traditional risk factors. Biological age may be important in determining total risk of patients. During assessment of cumulative CVRF effects on human body, presence of biological aging signs may be useful in identi...

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Gray Hair in Black Males A Possible Risk Factor in Coronary Artery Disease

Cited by 13 publications

References 5 publications

Premature graying of hair: An independent risk marker for coronary artery disease in smokers - A retrospective case control study

Premature graying of hair: An independent risk marker for coronary artery disease in smokers - A retrospective case control study

Premature graying of hair: An independent risk marker for coronary artery disease in smokers - A retrospective case control study

The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age

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