Gray matter decrease in patients with chronic tension type headache

Schmidt‐Wilcke, Tobias; Leinisch, Elke; Straube, Andreas; Kämpfe, N.; Draganski, Bogdan; Hc, Diener; Bogdahn, Ulrich; A, May

doi:10.1212/01.wnl.0000183067.94400.80

Cited by 385 publications

(285 citation statements)

References 7 publications

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“…Using these methods, both global searches (with no a priori hypotheses) and directed searches were performed in regions predicted to show anatomical changes. Based on regions shown to have anatomical changes in other voxel-based morphometry studies of chronic pain conditions (Apkarian et al, 2004;Schmidt-Wilcke et al, 2005 and stress-related disorders, including chronic fatigue syndrome and post-traumatic stress disorder (Villarreal et al, 2002;Okada et al, 2004;Chen et al, 2006), directed searches were performed in anterior, mid, and posterior cingulate cortex, insular cortex, dorsolateral prefrontal cortex, medial prefrontal cortex, and the parahippocampal gyrus.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence now indicates that a number of chronic pain and stress-related disorders, including chronic low back pain, tension-type headache, chronic fatigue syndrome, and posttraumatic stress disorder, are characterized by gray matter reductions, although the specific regions involved differ among syndromes (Villarreal et al, 2002;Apkarian et al, 2004;Okada et al, 2004;de Lange et al, 2005;Schmidt-Wilcke et al, 2005;Chen et al, 2006). The extensive comorbidity among these disorders suggests that mechanistic similarities may underlie brain atrophy, whereas the regional differences in gray matter decline could explain differences in symptoms.…”

Section: Structural Brain Changes Related To Chronic Pain and Stress mentioning

confidence: 99%

“…Changes in brain morphology have been described in chronic pain conditions (Apkarian et al, 2004;Schmidt-Wilcke et al, 2005, chronic fatigue syndrome (Okada et al, 2004;de Lange et al, 2005), and posttraumatic stress disorder (Villarreal et al, 2002;Corbo et al, 2005;Chen et al, 2006). Because fibromyalgia shares commonalities with these disorders, we hypothesized that fibromyalgia might be associated with neuroanatomical abnormalities as well.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?

Kuchinad

Schweinhardt²,

Seminowicz³

et al. 2007

J. Neurosci.

537

361

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Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in women. It has traditionally been classified as either a musculoskeletal disease or a psychological disorder. Accumulating evidence now suggests that fibromyalgia may be associated with CNS dysfunction. In this study, we investigate anatomical changes in the brain associated with fibromyalgia. Using voxel-based morphometric analysis of magnetic resonance brain images, we examined the brains of 10 female fibromyalgia patients and 10 healthy controls. We found that fibromyalgia patients had significantly less total gray matter volume and showed a 3.3 times greater ageassociated decrease in gray matter than healthy controls. The longer the individuals had had fibromyalgia, the greater the gray matter loss, with each year of fibromyalgia being equivalent to 9.5 times the loss in normal aging. In addition, fibromyalgia patients demonstrated significantly less gray matter density than healthy controls in several brain regions, including the cingulate, insular and medial frontal cortices, and parahippocampal gyri. The neuroanatomical changes that we see in fibromyalgia patients contribute additional evidence of CNS involvement in fibromyalgia. In particular, fibromyalgia appears to be associated with an acceleration of age-related changes in the very substance of the brain. Moreover, the regions in which we demonstrate objective changes may be functionally linked to core features of the disorder including affective disturbances and chronic widespread pain.

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Section: Discussionmentioning

confidence: 99%

Section: Structural Brain Changes Related To Chronic Pain and Stress mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?

Kuchinad

Schweinhardt²,

Seminowicz³

et al. 2007

J. Neurosci.

537

361

View full text Add to dashboard Cite

show abstract

“…Loss of grey matter may contribute to some of the cognitive deficits that have been described in chronic pain patients. Voxel-based morphometry has been used to examine region-specific changes in grey matter volume in chronic pain patients, with regions such as the IC, the ACC and the dorsolateral PFC consistently showing reduced volumes (Apkarian et al, 2004b;Kuchinad et al, 2007;Luerding et al, 2008;May, 2008;Schmidt-Wilcke et al, 2006;Schmidt-Wilcke et al, 2005;Schmidt-Wilcke et al, 2007;Valfre et al, 2008). As discussed earlier in this section, the IC and the ACC are commonly implicated in both pain-experience processing and cognitive processing.…”

Section: Brain Morphologymentioning

confidence: 99%

The effect of pain on cognitive function: A review of clinical and preclinical research

Moriarty

McGuire

Finn

2011

Progress in Neurobiology

900

710

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Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical and preclinical studies that have investigated pain-related alterations in cognition. These include impaired attentional, executive and general cognitive functioning. We describe the anatomical, neurochemical and molecular substrates common to both cognitive processing and supraspinal pain processing, and present the evidence for their involvement in pain-related cognitive impairment. We also examine the added complexity of cognitive impairment caused by analgesic medications and how this can further impact on morbidity in chronic pain patients. The need for a better understanding of the mechanisms of both pain-induced and treatment-related cognitive impairment is highlighted. Further research in this area will aid our understanding of patient symptoms and their underlying pathophysiology, ultimately leading to increased provision of guided therapy.

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“…This article is available in: http://headache.imedpub.com/ also evidence of white matter abnormalities in elderly patients with TTH (34% of the sample compared with 7% of headachefree controls) [80,81]. Further, recent research shows that CTTH is associated with impaired motor learning [82].…”

Section: Journal Of Headache and Pain Managementmentioning

confidence: 99%

Tension-Type Headache: A Life-Course Review

Waldie

Buckley²,

Bull³

et al. 2015

Journal of Headache &Amp; Pain Management

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Background: Tension-type headache is the most prevalent primary headache type worldwide and is associated with a wide spectrum of disability. Although progress has been made in understanding the complex mechanisms that lead to the pathogenesis of tension-type headache, to date there are no clear-cut markers of what makes tension-type headache unique. Due to a relative lack of research (compared to migraine), the pathophysiology of tension-type headache is not well understood and there are gaps in the epidemiological data, particularly from Australasia.

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Gray matter decrease in patients with chronic tension type headache

Cited by 385 publications

References 7 publications

Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?

Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?

The effect of pain on cognitive function: A review of clinical and preclinical research

Tension-Type Headache: A Life-Course Review

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