Gray matter volume abnormalities and clinical correlates in OCD with exclusive washing dimension

Kodancha, Prabhath Gujjadi; Shivakumar, Venkataram; Jose, Dania; Venkatasubramanian, Ganesan; Reddy, Y.C. Janardhan; Narayanaswamy, Janardhanan C.

doi:10.1016/j.ajp.2020.102343

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…Therefore, we inferred that the changed GMV and dFC may be a trait alteration of OCD and not dependent on the current clinical status [ 59 , 60 ]. However, the GMV of the left STG was negatively correlated with the severity of OCD [ 7 ]. The heterogeneity of OCD, relatively small sample sizes, and rigorous Bonferroni correction might limit the relationship between abnormal multimodal MRI characteristics and clinical factors in OCD, and may explain this contradiction [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

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Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder

Ding

Chen

et al. 2023

BMC Psychiatry

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Background Previous studies discovered the presence of abnormal structures and functions in the brain regions of patients with obsessive-compulsive disorder (OCD). Nevertheless, whether structural changes in brain regions are coupled with alterations in dynamic functional connectivity (dFC) at rest in medicine-free patients with OCD remains vague. Methods Three-dimensional T1-weighed magnetic resonance imaging (MRI) and resting-state functional MRI were performed on 50 medicine-free OCD and 50 healthy controls (HCs). Firstly, the differences in gray matter volume (GMV) between OCD and HCs were compared. Then, brain regions with aberrant GMV were used as seeds for dFC analysis. The relationship of altered GMV and dFC with clinical parameters in OCD was explored using partial correlation analysis. Finally, support vector machine was applied to examine whether altered multimodal imaging data might be adopted to distinguish OCD from HCs. Results Our findings indicated that GMV in the left superior temporal gyrus (STG) and right supplementary motor area (SMA) was reduced in OCD, and the dFC between the left STG and the left cerebellum Crus I and left thalamus, and between the right SMA and right dorsolateral prefrontal cortex (DLPFC) and left precuneus was decreased at rest in OCD. The brain regions both with altered GMV and dFC values could discriminate OCD from HCs with the accuracy of 0.85, sensitivity of 0.90 and specificity of 0.80. Conclusion The decreased gray matter structure coupling with dynamic function in the left STG and right SMA at rest may be crucial in the pathophysiology of OCD. Trial registration Study on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (registration date: 08/11/2017; registration number: ChiCTR-COC-17,013,301).

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Section: Discussionmentioning

confidence: 99%

“…Voxel-based morphometry (VBM) studies discovered that the gray matter volume (GMV) in the striatum and pallidum was increased, and that in the prefrontal and cingulate cortex was decreased in OCD [ 5 , 6 ]. In addition, the GMV of the left superior temporal gyrus (STG) was negatively correlated with the severity of OCD [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder

Ding

Chen

et al. 2023

BMC Psychiatry

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“…1 Previous studies have found brain volume loss/atrophy in the CSTC circuit in patients with OCD. 2 Synaptic loss is associated with a variety of neurodegenerative diseases and mental disorders, and is correlated with the clinical severity assessed by positron emission tomography (PET) imaging of synaptic vesicular glycoprotein 2A (SV2A) in vivo. 3 There is limited research on the loss of synaptic protein markers in OCD.…”

Section: Introductionmentioning

confidence: 99%

Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder

Xiao,

Hou,

Xiao

et al. 2024

Gen Psych

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BackgroundUnderstanding synaptic alteration in obsessive-compulsive disorder (OCD) is crucial for elucidating its pathological mechanisms, butin vivoresearch on this topic remains limited.AimsThis study aimed to identify the synaptic density indicators in OCD and explore the relationship between cognitive dysfunction and synaptic density changes in OCD.MethodsThis study enrolled 28 drug-naive adults with OCD aged 18–40 years and 16 healthy controls (HCs). Three-dimensional T1-weighted structural magnetic resonance imaging and18F-SynVesT-1 positron emission tomography were conducted. Cognitive function was assessed using the Wisconsin Cart Sorting Test (WCST) in patients with OCD and HCs. Correlative analysis was performed to examine the association between synaptic density reduction and cognitive dysfunction.ResultsCompared with HCs, patients with OCD showed reduced synaptic density in regions of the cortico-striato-thalamo-cortical circuit such as the bilateral putamen, left caudate, left parahippocampal gyrus, left insula, left parahippocampal gyrus and left middle occipital lobe (voxel p<0.001, uncorrected, with cluster level above 50 contiguous voxels). The per cent conceptual-level responses of WCST were positively associated with the synaptic density reduction in the left middle occipital gyrus (R2=0.1690, p=0.030), left parahippocampal gyrus (R2=0.1464, p=0.045) and left putamen (R2=0.1967, p=0.018) in patients with OCD.ConclusionsAdults with OCD demonstrated lower18F-labelled difluoro analogue of18F-SynVesT-1 compared with HCs, indicating potentially lower synaptic density. This is the first study to explore the synaptic density in patients with OCD and provides insights into potential biological targets for cognitive dysfunctions in OCD.

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A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive–compulsive disorder

Yang

Xiao

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Gray matter volume abnormalities and clinical correlates in OCD with exclusive washing dimension

Cited by 8 publications

References 38 publications

Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder

Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder

Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder

A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive–compulsive disorder

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