Gray matter volume and dual-task gait performance in mild cognitive impairment

Doi, Takehiko; Blumen, Helena M.; Verghese, Joe; Shimada, Hiroyuki; Makizako, Hyuma; Tsutsumimoto, Kota; Hotta, Ryo; Nakakubo, Sho; Suzuki, Takao

doi:10.1007/s11682-016-9562-1

Cited by 49 publications

(41 citation statements)

References 73 publications

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“…Structures comprising the GM networks associated with NPW speed in older adults without dementia reported in this study are consistent with aspects of existing literature (Allali et al, ; Callisaya et al, ; Doi et al, ; Ezzati, Katz, Lipton, Lipton, & Verghese, ; Nadkarni et al, ; Rosano et al, ). Broadly, these similarities indicate that single‐task gait speed is associated with GM networks composed of structures in both the motor and the control pathways of locomotion (Leisman, Moustafa, & Shafir, ).…”

Section: Discussionsupporting

confidence: 92%

“…One reason for increasing DTC with aging is age‐related atrophy in the brain, which follows a variable course. In addition to interindividual variability in the overall patterns of GMV atrophy, population‐wide studies have shown that some areas, such as the PFC, atrophy more than others (Doi et al, ; Dumurgier et al, ; Storsve et al, ). One other study (Allali et al, ) has looked at the GMV networks associated with walking speed during dual‐task performance.…”

Section: Discussionmentioning

confidence: 99%

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Gray matter volume covariance networks associated with dual‐task cost during walking‐while‐talking

Tripathi

Verghese

Blumen

2019

Human Brain Mapping

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We studied gray matter volume covariance networks associated with normal pace walking (NPW) speed and dual‐task costs (DTCs) during walking‐while‐talking (WWT)—a mobility stress test that involves walking while reciting alternate letters of the alphabet. Using a multivariate covariance‐based analytic approach, we identified gray matter networks associated with NPW speed (mean 102.1 cm/s ±22.5 cm/s) and DTC (percent difference in gait speed between NPW and WWT, mean 25.9% ± 18.8%) in 139 older adults without dementia (M = 75.3 ± 6.1 years). The gray matter network associated with NPW was primarily composed of supplementary motor area, precuneus cortex, and the middle frontal gyrus. Greater expression of this NPW network was associated with better processing speed (trail‐making test A [r = −0.30, p = 0.005]) and executive function (trail‐making test B − A [r = −0.43, p < 0.0001]). The gray matter network associated with DTC was primarily composed of medial prefrontal, cingulate, and thalamic regions. Greater expression of this DTC network was associated with better episodic memory performance on the free and cued selective reminding test (r = 0.30, p = 0.007). These results suggest that NPW speed and DTC are supported by different networks, and are associated with different cognitive domains.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Gray matter volume covariance networks associated with dual‐task cost during walking‐while‐talking

Tripathi

Verghese

Blumen

2019

Human Brain Mapping

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“…Further functional imaging studies are warranted to investigate the specific roles of these regions in dual task performance and automaticity. In general, our findings on cognitive-relevant brain volumes are consistent with other research showing that decreased volume is associated with a worse performance during DT in those with cognitive impairment (Doi et al 2017). They also highlight the utility of DT performance metrics beyond mDTE as has been suggested in other populations (Longhurst and Landers 2019;Plummer and Eskes 2015;Plummer et al 2013;Yang et al 2017).…”

Section: Discussionsupporting

confidence: 91%

“…Likewise, there is little known about the relationship between DT function and cognitive relevant brain areas. Previous studies have identified brain areas uniquely correlated with DT performance, including frontal, temporal, and cingulate regions (Doi et al 2017;Tripathi et al 2019). While not the hallmark of cognitive disorders, there is evidence of decreased volume, decrease neuronal integrity, and lower cerebral blood flow in motor-related brain areas such as the basal ganglia and primary motor cortex in those with MCI and dementia, and these findings have been shown to be associated with both single and dual task gait variability (Annweiler et al 2013;Jiji et al 2013;Nakamura et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Brain volumes and dual-task performance correlates among individuals with cognitive impairment: a retrospective analysis

et al. 2020

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Cognitive impairment (CI) is a prevalent condition characterized by loss of brain volume and changes in cognition, motor function, and dual-tasking ability. To examine associations between brain volumes, dual-task performance, and gait and balance in those with CI to elucidate the mechanisms underlying loss of function. We performed a retrospective analysis of medical records of patients with CI and compared brain volumes, dual-task performance, and measures of gait and balance. Greater cognitive and combined dual-task effects (DTE) are associated with smaller brain volumes. In contrast, motor DTE is not associated with distinct pattern of brain volumes. As brain volumes decrease, dual-task performance becomes more motor prioritized. Cognitive DTE is more strongly associated with decreased performance on measures of gait and balance than motor DTE. Decreased gait and balance performance are also associated with increased motor task prioritization. Cognitive DTE appears to be more strongly associated with decreased automaticity and gait and balance ability than motor DTE and should be utilized as a clinical and research outcome measure in this population. The increased motor task prioritization associated with decreased brain volume and function indicates a potential for accommodative strategies to maximize function in those with CI. Counterintuitive correlations between motor brain volumes and motor DTE in our study suggest a complicated interaction between brain pathology and function.

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“…Furthermore, these functional compensation mechanisms might be linked to the natural occurrence of brain atrophy during lifetime. Previous studies showed that PFC atrophies more than other regions ( Dumurgier et al, 2012 ; Storsve et al, 2014 ; Doi et al, 2017 ) and is also often functionally underutilized with age ( Holtzer et al, 2011 ). Several studies showed an association of DT performance (i.e., processing speed and executive function) and the gray matter volume of various areas of motor control including PFC ( Allali et al, 2019 ; Blumen et al, 2019 ; Tripathi et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Neural Correlates of Stepping in Healthy Elderly: Parietal and Prefrontal Cortex Activation Reflects Cognitive-Motor Interference Effects

Reinhardt

Rus-Oswald

Bürki

et al. 2020

Front. Hum. Neurosci.

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Gait analysis involving cognitive-motor dual task (DT) is a diagnostic tool in geriatrics. Cognitive-motor interference effects during DT, such as decreased walking speed and increased step-to-step variability, have a high predictive value for fall risk and cognitive decline. Previously we showed the feasibility of DT during functional magnetic resonance imaging (fMRI) using an MRI-compatible stepping device. Here, we improved the DT-fMRI protocol with respect to task difficulty and signal robustness, making it more suitable for individualized analysis to better understand the neuronal substrates of cognitive-motor interference effects. Thirty healthy elderly subjects performed cognitive and motor single tasks (ST; stepping or finger tapping), as well as combined cognitive-motor DT during fMRI. After whole brain group level analysis, a region-of-interest (ROI) analysis and the computation of dual task costs (DTC = activation difference ratio ST/DT) at individual level were performed. Activations in the primary (M1) and secondary motor as well as in parietal and prefrontal cortex were measured at the group level during DT. Motor areas showed decreased activation whereas parietal and prefrontal areas showed increased activation in DT vs. ST. Stepping yielded more distinctive activations in DT vs. ST than finger tapping. At the individual level, the most robust activations (based on occurrence probability and signal strength) were measured in the stepping condition, in M1, supplementary motor area (SMA) and superior parietal lobule/intraparietal sulcus (SPL/IPS). The distribution of individual DTC in SPL/IPS during stepping suggested a separation of subjects in groups with high vs. low DTC. This study proposes an improved cognitive-motor DT-fMRI protocol and a standardized analysis routine of functional neuronal markers for cognitive-motor interference at the individual level.

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Gray matter volume and dual-task gait performance in mild cognitive impairment

Cited by 49 publications

References 73 publications

Gray matter volume covariance networks associated with dual‐task cost during walking‐while‐talking

Gray matter volume covariance networks associated with dual‐task cost during walking‐while‐talking

Brain volumes and dual-task performance correlates among individuals with cognitive impairment: a retrospective analysis

Neural Correlates of Stepping in Healthy Elderly: Parietal and Prefrontal Cortex Activation Reflects Cognitive-Motor Interference Effects

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