Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study

Lan, Dongyi; Zhu, Pei‐Wen; Xu, Qianhui; Su, Ting; Li, Biao; Shi, Wen‐Qing; Lin, Qian; Yang, Yuan; Yuan, Qing; Fang, Jian-Wen; Shao, Yi

doi:10.1167/tvst.8.1.1

Cited by 13 publications

(11 citation statements)

References 56 publications

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“…31 Accumulated neuroimaging evidence has indicated that the anterior cingulate cortex was involved in emotional regulation, cognitive processes, and specific motor functions. 11,37,38 Previously, Silkiss et al found thinning of the grey matter sheet in the right anterior cingulate and they linked it to the emotional disturbances in TAO. 11 Similarly, we also found decreased nodal properties in the right anterior cingulate, and negative correlations were observed between nodal degree in the right ACG and HARS as well as HDRS scores.…”

Section: Discussionmentioning

confidence: 99%

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

Wen

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Increasing evidence indicated that thyroid-associated ophthalmopathy (TAO) might be a neural related disease more than an ocular disease. In this study, we aimed to investigate the alterations of structural brain connectome in patients with TAO. METHODS.Twenty-seven patients with TAO and 27 well-matched healthy controls underwent diffusion tensor imaging. Graph theoretical analyses, including global (shortest path length, clustering coefficient, small-worldness, global efficiency, and local efficiency) and nodal (nodal betweenness, nodal degree, and nodal efficiency) topological properties and network-based statistics were performed to evaluate TAO-related changes in brain network pattern. Correlations were assessed between the network properties and clinical variables, including disease duration, visual acuity, neuropsychiatric measurements, and serum thyroid function indexes. RESULTS.Compared with healthy controls, patients with TAO exhibited preserved global network parameters but altered nodal properties. We found decreased nodal betweenness and nodal degree in right anterior cingulate and paracingulate gyri, decreased nodal degree and nodal efficiency in the right orbital part of middle frontal gyrus (ORBmid), whereas increased nodal degree and nodal efficiency in the left cuneus. Decrease of structural connectivity strength was found involving the right ORBmid, right putamen, left caudate nucleus, and left medial superior frontal gyrus. Significant correlations were also found between nodal properties and neuropsychological performances as well as visual acuity. CONCLUSIONS.Patients with TAO developed disruption of structural brain network connectome. Disrupted topological organization of the brain structural network may be associated with the clinical-psychiatric dysfunction of patients with TAO.

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Section: Discussionmentioning

confidence: 99%

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

Wen

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…For example, it is possible that the image using IR may show a large difference between an inappropriate phantom and in‐vivo CSF. Studies utilizing tissue volumes are actively conducted with voxel‐based morphometry of brain tissue . In order to enhance the contrast between white matter and gray matter, the IR pulse may be used in advance.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid T1 value phantom reproduction at scan room temperature

Yamashiro

Kobayashi

Saito

2019

J Applied Clin Med Phys

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The T1 value of pure water, which is often used as a phantom to simulate cerebrospinal fluid, is significantly different from that of in‐vivo cerebrospinal fluid. The purpose of this study was to develop a phantom with a T1 value equivalent to that of in‐vivo cerebrospinal fluid under examination room temperature (23°C–25°C). In this study, 1.5 and 3.0 T magnetic resonance imaging scanners were used. We examined the signal intensity change in relation to pure water temperature, the T1 values of acetone‐diluted solutions (0–100 v/v%, in 10 steps), and the correlation coefficients obtained from volunteers and the prepared phantoms. The T1 value was close to the value reported in the literature for cerebrospinal fluid when the acetone‐diluted solution was 70 v/v% or higher at scan room temperature. The value at that time was 3532.81–4704.57 ms at 1.5 T and it ranged from 4052.41 to 5701.61 ms at 3.0 T. The highest correlation with the values obtained from the volunteers was r = 0.993 with pure acetone at 1.5 T and r = 0.991 with acetone 90 v/v% at 3.0 T. The relative error of the best phantom‐volunteer match was 32.61 (%) ± 6.71 at 1.5 T and 46.67 (%) ± 4.31 at 3.0 T. The T1 value measured by the null point method did not detect a significant difference between in vivo CSF and acetone 100 v/v% at 1.5 T and acetone 90 v/v% at 3.0 T. The T1 value of cerebrospinal fluid in the living body at scan room temperature was reproduced with acetone. The optimum concentration of acetone for cerebrospinal‐fluid reproduction was pure acetone at 1.5 T and 90 v/v% at 3.0 T.

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“…We preprocessed the structural image data using the voxel-based morphometry toolbox (VBM8, http://dbm.neuro.uni-jena.de/vbm8/ ), Statistical Parametric Mapping (SPM8, http://www.fil.ion.ucl.ac.uk ), and MATLAB 7.9.0 software (R2009b; The Mathworks, Inc, Natick, MA, USA). The brains were divided into three parts as gray matter, white matter and cerebrospinal fluid using the default estimation options on VBM8, as previously described 18 . The preprocessed data were then standardized to conform to the Montreal Neurological Institute (MNI) criteria.…”

Section: Methodsmentioning

confidence: 99%

Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study

Zhu

et al. 2022

Sci Rep

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This study proposes the use of the voxel-based morphometry (VBM) technique to investigate structural alterations of the cerebral cortex in patients with strabismus and amblyopia (SA). Sixteen patients with SA and sixteen healthy controls (HCs) underwent magnetic resonance imaging. Original whole brain images were analyzed using the VBM method. Pearson correlation analysis was performed to evaluate the relationship between mean gray matter volume (GMV) and clinical manifestations. Receiver operating characteristic (ROC) curve analysis was applied to classify the mean GMV values of the SA group and HCs. Compared with the HCs, GMV values in the SA group showed a significant difference in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, bilateral parahippocampal gyrus, and left anterior cingulate cortex. The mean GMV value in the right superior temporal gyrus, posterior and anterior lobes of the cerebellum, and bilateral parahippocampal gyrus were negatively correlated with the angle of strabismus. The ROC curve analysis of each cerebral region confirmed the accuracy of the area under the curve. Patients with SA have reduced GMV values in some brain regions. These findings might help to reveal the potential pathogenesis of SA and its relationship with the atrophy of specific regions of the brain.

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Gray Matter Volume Changes in Patients With Acute Eye Pain: A Voxel-Based Morphometry Study

Cited by 13 publications

References 56 publications

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

Cerebrospinal fluid T1 value phantom reproduction at scan room temperature

Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study

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