Gray matter volumes in patients with bipolar disorder and their first-degree relatives

Nery, Fabiano G.; Gigante, Alexandre Duarte; Amaral, José Antônio; Fernandes, Flávia Rodrigues; Berutti, Mariangeles; Almeida, Karla Mathias de; Carneiro, Camila de Godoi; Duran, Fábio Luís de Souza; Otaduy, Maria G.; Leite, Cláudia C.; Busatto, Geraldo F.; Lafer, Beny

doi:10.1016/j.pscychresns.2015.09.005

Cited by 12 publications

(7 citation statements)

References 64 publications

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“…3,4 In contrast, previous studies have reported that individuals with BD have a volume reduction in various brain regions including the bilateral dorsolateral prefrontal cortex, left hippocampus, cerebellum, left rostral anterior cingulate cortex, fronto-insular cortex, and the medial orbitofrontal region. [5][6][7][8][9][10] A few studies have reported volume reduction in the subcallosal area (SCA, Brodmann area 25), which is adjacent to the rostral part of the sgACC and has been known as a target area for deep brain stimulation (DBS) in cases of treatmentresistant MDD and BD, 11,12 suggesting the involvement of the SCA in the pathogenesis of both MDD and BD. [13][14][15] The sgACC and SCA are reportedly difficult to separate.…”

Section: Introductionmentioning

confidence: 99%

Regional brain volume reductions in major depressive disorder and bipolar disorder: An analysis by voxel‐based morphometry

Niida

Yamagata

Niida

et al. 2018

Int J Geriat Psychiatry

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Objectives The present study investigated the usefulness of evaluating the existence of volume reduction in brain regions using voxel‐based morphometry (VBM) to dissociate major depressive disorder (MDD) from bipolar disorder (BD). Methods/Design This study enrolled 92 individuals with MDD, 32 individuals with BD, and 43 healthy controls (HCs). We focused on gray matter volume (GMV) of the subgenual anterior cingulate cortex (sgACC), subcallosal area (SCA), and hippocampus. The degree of volume reduction in these brain regions was calculated as the z score, and the differences of z scores in these regions were investigated among the MDD, BD, and HC groups. We then performed a receiver operating characteristic curve analysis to dissociate the individuals with MDD and BD from the HCs based on the z scores in the GMV of these brain regions. Results While there were no significant differences in the z scores of the hippocampus among the three groups, the z score of the sgACC was significantly higher in the MDD group than in the BD and HC groups, and the SCA z score was significantly higher in the MDD and BD groups than in the HC group. Conclusions Our findings suggest that VBM evaluation of GMV reduction in the sgACC may be useful as an objective adjunctive tool to distinguish between MDD and BD.

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Section: Introductionmentioning

confidence: 99%

Regional brain volume reductions in major depressive disorder and bipolar disorder: An analysis by voxel‐based morphometry

Niida

Yamagata

Niida

et al. 2018

Int J Geriat Psychiatry

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show abstract

“…Despite an association between genetic liability for BD and GM volumes in regions of the anterior cingulate cortex, ventral striatum, medial frontal gyrus, right precentral gyrus, right insular cortex, and medial orbital gyrus [57], the absence of evidence for GM abnormalities and contradictory findings [61, 62] across studies in BD-FDR may be due to nongenetic factors such as age, clinical features, medication, duration illness, pubertal stage, and age of onset [63–67]. Increased GM volume or thickness of these regions may be consequent of neuroprotective compensatory mechanisms or abnormal brain maturation due to the maladaptive pruning in at-risk group or may be associated with resilience [59].…”

Section: Resultsmentioning

confidence: 99%

Neurobiology of Risk for Bipolar Disorder

Özerdem

Ceylan

Can

2016

Curr Treat Options Psych

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Opinion statementBipolar disorder (BD) is a chronic mental illness which follows a relapsing and remitting course and requires lifetime treatment. The lack of biological markers for BD is a major difficulty in clinical practice. Exploring multiple endophenotypes to fit in multivariate genetic models for BD is an important element in the process of finding tools to facilitate early diagnosis, early intervention, prevention of new episodes, and follow-up of treatment response in BD. Reviewing of studies on neuroimaging, neurocognition, and biochemical parameters in populations with high genetic risk for the illness can yield an integrative perspective on the neurobiology of risk for BD. The most up-to-date data reveals consistent deficits in executive function, response inhibition, verbal memory/learning, verbal fluency, and processing speed in risk groups for BD. Functional magnetic resonance imaging (fMRI) studies report alterations in the activity of the inferior frontal gyrus, medial prefrontal cortex, and limbic areas, particularly in the amygdala in unaffected first-degree relatives (FDR) of BD compared to healthy controls. Risk groups for BD also present altered immune and neurochemical modulation. Despite inconsistencies, accumulating data reveals cognitive and imaging markers for risk and to a less extent resilience of BD. Findings on neural modulation markers are preliminary and require further studies. Although the knowledge on the neurobiology of risk for BD has been inadequate to provide benefits for clinical practice, further studies on structural and functional changes in the brain, neurocognitive functioning, and neurochemical modulation have a potential to reveal biomarkers for risk and resilience for BD. Multimodal, multicenter, population-based studies with large sample size allowing for homogeneous subgroup analyses will immensely contribute to the elucidation of biological markers for risk for BD in an integrative model.

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“…Indivíduos com TB que relataram ter sofrido maus-tratos durante a infância, especialmente abuso, tinham maior risco de sofrer de doenças médicas e necessitar de maior atenção clínica (Hosang et al, 2017) que controles saudáveis e que portadores de TB sem história de exposição a MTI. (Matsuo et al, 2009;Radenbach et al, 2010;Azevedo-Marques et al, 2011;Houenou et al, 2011;Selvaraj et al, 2012;Nortje et al, 2013;Nery et al, 2015;Neves et al, 2015). (2017)…”

Section: Maus-tratos Na Infância E Suas Consequênciasunclassified

“…Na literatura, existe consenso indicando que, em pacientes que sofreram MTI (abusos e negligências), o TB vem sendo associado com idade de início mais precoce, pior evolução clínica, maior número de tentativas de suicídio, presença de episódios/sintomas psicóticos, mais comorbidades clínicas e psiquiátricas (transtornos de ansiedade e estresse pós-traumático), ciclagem rápida, maior número de episódios maníacos e depressivos, maior incidência de abuso de álcool e substâncias e pior funcionamento psicossocial (Sala et al, 2014;Agnew-Blais;Danese, 2016;Aas et al, 2016;Dualibe;Osório, 2017). (Matsuo et al, 2009;Radenbach et al, 2010;Azevedo-Marques et al, 2011;Houenou et al, 2011;Selvaraj et al, 2012;Nortje et al, 2013;Nery et al, 2015;Neves et al, 2015). (Saleh et al, 2017).…”

Section: Os Dados Daunclassified

A associação entre traumas na infância, funcionamento cognitivo e morfologia cerebral em pacientes com transtorno bipolar tipo I

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Gray matter volumes in patients with bipolar disorder and their first-degree relatives

Cited by 12 publications

References 64 publications

Regional brain volume reductions in major depressive disorder and bipolar disorder: An analysis by voxel‐based morphometry

Regional brain volume reductions in major depressive disorder and bipolar disorder: An analysis by voxel‐based morphometry

Neurobiology of Risk for Bipolar Disorder

A associação entre traumas na infância, funcionamento cognitivo e morfologia cerebral em pacientes com transtorno bipolar tipo I

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