Sixty-three patients with the clinical suspicion of acute cholecystitis were examined with infusion tomography of the gallbladder. Ultrasonography was performed in 51 of these cases. The technique and diagnostic principles of both methods are discussed. The diagnostic value of the two methods when used in combination is stressed. Thus in a case of gangrenous cholecystitis when opacification of the gallbladder wall may not appear at infusion tomography, ultrasonography may demonstrate signs of gallbladder disease. Infusion tomography, on the other hand, may be of great value if ultrasonography is not informative.In acute cholecystitis there is reason to believe that surgical intervention should be carried out as early as possible in order to reduce mortality [1-4]. The need for rapid and reliable diagnostic methods is therefore obvious. If the patient has a history of repeated attacks of biliary colic and is admitted to the hospital with fever, pain, and tenderness localized in the right upper quadrant of the abdomen, the diagnosis of acute cholecystitis is likely, at least if earlier cholecystography has proved the presence of cholelithiasis and/or nonfunctioning gallbladder. In such instances, there is seldom need for further diagnostic considerations before operative intervention. However, many patients with acute cholecystitis have no history of abdominal pain and the clinical diagnosis is not firm enough to indicate an acute operation.