Gray-to-white matter ratio predicts long-term recovery potential of patients with aneurysmal subarachnoid hemorrhage

Ali, Achmet; Bitir, Burcu; Abdullah, Taner; Sabancı, Pulat Akın; Aras, Yavuz; Aydöseli, Aydın; Tanirgan, Gamze; Sencer, Serra; Akıncı, İbrahim Özkan

doi:10.1007/s10143-018-1029-y

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…The detailed alteration of cognitive impairment after aSAH has been always a vital problem for researchers (Welmer et al, 2006;Al-Khindi et al, 2010;Ali et al, 2020). Because improvement on current treatment or development of new interventional strategy depends on our understanding of neural mechanism.…”

Section: Discussionmentioning

confidence: 99%

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Zheng

Zhang

Wan

et al. 2021

Front. Aging Neurosci.

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Aneurysmal subarachnoid hemorrhage (aSAH) is a common disease causing vascular dementia. Survivors often suffer from cognitive impairment especially working memory deficit. Currently, lack of theoretical support limits the improvement of cognitive intervention or rehabilitation. It is unclear how the large-scale network differs and to what extent is the brain network affected? Our study aims to provide novel information about the topological characteristics of brain organization, especially “small-world” property. A total of 62 aSAH patients are enrolled in this study. They are divided into two groups according to the syndrome of working memory deficit. Their working memory function is evaluated by TMT-B and AVLT (Chinese version). Functional MRI scan is also performed for detecting resting-state cortical plasticity. We utilized ICA to extract functional sub-networks including working memory network from imaging data. And then we establish binarized network and calculate the small-worldness property as well as local and global efficiency of networks. aSAH group with working memory deficit shows no significant difference of clustering coefficient with control group. Our study discovered significant decrease of characteristic path length indicating an increase of overall routing efficiency. We reason that patients with working memory deficit have to recruit more neuronal resources and thus develops higher overall routing efficiency of local network. This study provides novel information about the neural alterations of aSAH patients with working memory deficit. It might contribute to the understanding of neural mechanism and the improvement of current intervention for vascular dementia.

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Section: Discussionmentioning

confidence: 99%

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Zheng

Zhang

Wan

et al. 2021

Front. Aging Neurosci.

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“…Subsequently, Rejmer et al reported that the mean white matter diffusion rate 2 weeks after onset in 49 patients with aneurysmal SAH was higher than that in 22 patients with unruptured aneurysms (4). Moreover, the gray matter/white matter ratio has been proved to be a good predictor for long-term cognitive function and quality of life in SAH patients (20). These studies suggest that it is essential to pay attention to white matter injury for the recovery of neurological function after SAH.…”

Section: White Matter Injury After Sahmentioning

confidence: 96%

Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage

Gao

Zhou

et al. 2021

Front. Neurol.

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Aneurysmal subarachnoid hemorrhage (SAH) is one of the special stroke subtypes with high mortality and mobility. Although the mortality of SAH has decreased by 50% over the past two decades due to advances in neurosurgery and management of neurocritical care, more than 70% of survivors suffer from varying degrees of neurological deficits and cognitive impairments, leaving a heavy burden on individuals, families, and the society. Recent studies have shown that white matter is vulnerable to SAH, and white matter injuries may be one of the causes of long-term neurological deficits caused by SAH. Attention has recently focused on the pivotal role of white matter injury in the pathophysiological processes after SAH, mainly related to mechanical damage caused by increased intracerebral pressure and the metabolic damage induced by blood degradation and hypoxia. In the present review, we sought to summarize the pathophysiology processes and mechanisms of white matter injury after SAH, with a view to providing new strategies for the prevention and treatment of long-term cognitive dysfunction after SAH.

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Transpulmonary thermodilution monitoring–guided hemodynamic management improves cognitive function in patients with aneurysmal subarachnoid hemorrhage: a prospective cohort comparison

et al. 2019

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Gray-to-white matter ratio predicts long-term recovery potential of patients with aneurysmal subarachnoid hemorrhage

Cited by 5 publications

References 30 publications

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage

Transpulmonary thermodilution monitoring–guided hemodynamic management improves cognitive function in patients with aneurysmal subarachnoid hemorrhage: a prospective cohort comparison

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