Gray zone lymphoma: A case report and comprehensive review of literature

Uczkowski, Dariusz; Ashraf, Hamza; Cherry, Mohamad; Dimov, Nikolay

doi:10.1016/j.lrr.2023.100372

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Oncologists also face challenges in managing GZL due to its aggressive nature and the lack of well-established treatment guidelines. 11 In conclusion, this case emphasizes the importance of a comprehensive evaluation of patients presenting with SPS to uncover any underlying conditions, even when the symptoms of SPS overshadow other clinical manifestations. This underscores the necessity of a multidisciplinary approach to arrive at a definitive diagnosis.…”

Section: Discussionmentioning

confidence: 70%

“…GZL, in particular, is a rare form of lymphoma that presents a diagnostic and clinical dilemma for pathologists due to its complex morphological and phenotypic characteristics. Oncologists also face challenges in managing GZL due to its aggressive nature and the lack of well‐established treatment guidelines 11 …”

Section: Discussionmentioning

confidence: 99%

“…Oncologists also face challenges in managing GZL due to its aggressive nature and the lack of well‐established treatment guidelines. 11 …”

Section: Discussionmentioning

confidence: 99%

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Stiff‐person syndrome revealing an occult gray zone lymphoma: A diagnostic challenge

Fakhari,

Poorsaadat,

Mohammad Talebi

et al. 2023

Clinical Case Reports

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Key Clinical MessageStiff‐Person Syndrome (SPS) can be associated with various malignancies, including lymphomas. Therefore, clinicians should always remain vigilant for the presence of an underlying malignancy, especially in older patients presenting with SPS.AbstractStiff‐person syndrome (SPS) is a rare neurological disorder characterized by painful muscle spasms. It can occur as a paraneoplastic syndrome associated with various malignancies. We present a case of an older male adult with a history of recurrent fever episodes and elevated inflammatory markers for 1 year who subsequently developed neurological symptoms. The presence of positive amphiphysin antibodies led to the diagnosis of SPS, which prompted further investigations revealing an underlying Gray Zone lymphoma (GZL). This case highlights the challenges in diagnosing lymphoma and emphasizes the importance of considering SPS as a paraneoplastic syndrome in guiding toward the final diagnosis. The diagnostic challenge in our case is summarized in Chart 1.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stiff‐person syndrome revealing an occult gray zone lymphoma: A diagnostic challenge

Fakhari,

Poorsaadat,

Mohammad Talebi

et al. 2023

Clinical Case Reports

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A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma

Guan,

Zhao,

Zhang

et al. 2024

Expert Review of Molecular Diagnostics

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Relapsed Gray Zone Lymphoma: A Rare Clinical Challenge

Chhabra,

Sahu,

Deshmukh

et al. 2024

Cureus

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Gray zone lymphoma (GZL) is an extremely uncommon hematological cancer with characteristics in common with both classical Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma. In this case report, we present a rare case of a 22-year-old male who developed HL initially and then transitioned to relapsed or refractory GZL. The disease relapsed twice throughout, even after the peripheral blood stem cell transplant. The initial biopsy suggested it was classical HL, and the biopsy was done late in the progression of the disease; the features suggested it was GZL. The treatment consisted of curative and preventive chemotherapy, radiation therapy, and immunotherapy.

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Gray zone lymphoma: A case report and comprehensive review of literature

Cited by 3 publications

References 27 publications

Stiff‐person syndrome revealing an occult gray zone lymphoma: A diagnostic challenge

Stiff‐person syndrome revealing an occult gray zone lymphoma: A diagnostic challenge

A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma

Relapsed Gray Zone Lymphoma: A Rare Clinical Challenge

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