GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease

Malagrinò, Francesca; Puglisi, Elena; Pagano, Livia; Travaglini-Allocatelli, Carlo; Toto, Angelo

doi:10.1016/j.bbrep.2024.101803

Biochemistry and Biophysics Reports

2024

DOI: 10.1016/j.bbrep.2024.101803

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GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease

Francesca Malagrinò,

Elena Puglisi,

Livia Pagano

et al.

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2024

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References 70 publications

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RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders

Checa-Robles,

Salvetat,

Cayzac

et al. 2024

IJMS

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Mental health disorders are devastating illnesses, often misdiagnosed due to overlapping clinical symptoms. Among these conditions, bipolar disorder, schizophrenia, and schizoaffective disorder are particularly difficult to distinguish, as they share alternating positive and negative mood symptoms. Accurate and timely diagnosis of these diseases is crucial to ensure effective treatment and to tailor therapeutic management to each individual patient. In this context, it is essential to move beyond standard clinical assessment and employ innovative approaches to identify new biomarkers that can be reliably quantified. We previously identified a panel of RNA editing biomarkers capable of differentiating healthy controls from depressed patients and, among depressed patients, those with major depressive disorder and those with bipolar disorder. In this study, we integrated Adenosine-to-Inosine RNA editing blood biomarkers with clinical data through machine learning algorithms to establish specific signatures for bipolar disorder and schizophrenia spectrum disorders. This groundbreaking study paves the way for the application of RNA editing in other psychiatric disorders, such as schizophrenia and schizoaffective disorder. It represents a first proof-of-concept and provides compelling evidence for the establishment of an RNA editing signature for the diagnosis of these psychiatric conditions.

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RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders

Checa-Robles,

Salvetat,

Cayzac

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease

Cited by 1 publication

References 70 publications

RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders

RNA Editing Signatures Powered by Artificial Intelligence: A New Frontier in Differentiating Schizophrenia, Bipolar, and Schizoaffective Disorders

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