Greasing the Wheels of Pharmacotherapy for Colorectal Cancer: the Role of Natural Polyphenols

Niu, Chengu; Zhang, Jing; Okolo, Patrick

doi:10.1007/s13668-023-00512-w

Cited by 2 publications

(1 citation statement)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extract from O. europaea Madural showed a phenolic composition very close to O. europaea Cobrançosa’s extract, switching only the third position for luteolin-7- O -glucoside and the fourth position to apigenin-7- O -glucoside. Considering that both apigenin-7- O -glucoside and apigenin derivates have been reported to possess antimicrobial properties [ 84 , 85 ], their higher concentration in O. europaea Cobrançosa, associated with its higher content of MUFAs, could be speculated as a possible reason for it achieving the best result against Salmonella Enteritidis (ATCC 13076), but further studies are needed. The present study also revealed for O. europaea Verdeal a slightly different profile compared to both other extracts, following the waning order of HT > apigenin derivative > luteolin-7- O -glucoside > verbascoside > apigenin-7- O -glucoside.…”

Section: Discussionmentioning

confidence: 99%

Potential Therapeutic Properties of Olea europaea Leaves from Selected Cultivars Based on Their Mineral and Organic Profiles

de Oliveira,

Machado,

Chéu

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Olive leaves are consumed as an extract or as a whole herbal powder with several potential therapeutic benefits attributed to polyphenols, tocopherol’s isomers, and flavonoids, among others. This study assessed the potential variance in the functional features presented by olive leaves from three different Portuguese cultivars—Cobrançosa, Madural, and Verdeal—randomly mix-cultivated in the geographical area of Vale de Salgueiros. Inorganic analysis determined their mineral profiles while an organic analysis measured their total phenolic and flavonoid content, and scanned their phenolic and tocopherol and fatty acid composition. The extracts’ biological activity was tested by determining their antimicrobial and antioxidant power as well as their ability to inhibit acetylcholinesterase, butyrylcholinesterase, MAO-A/B, and angiotensin-I-converting enzyme. The inorganic profiles showed them to be an inexpensive source able to address different mineral deficiencies. All cultivars appear to have potential for use as possible antioxidants and future alternative antibiotics against some multidrug-resistant microorganisms, with caution regarding the arsenic content in the Verdeal cultivar. Madural’s extract displayed properties to be considered a natural multitarget treatment for Alzheimer’s and Parkinson’s diseases, depression, and cardiometabolic and dual activity for blood pressure modulation. This work indicates that randomly cultivating different cultivars significantly modifies the leaves’ composition while keeping their multifaceted therapeutic value.

show abstract

Section: Discussionmentioning

confidence: 99%